Search Hotels in Sanctuary, Sanibel

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
14 Dec - 15 Dec
Tomorrow
15 Dec - 16 Dec
Next weekend
19 Dec - 21 Dec
In two weeks
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanctuary hotels

Apartment, Multiple Beds, Partial Ocean View | Beach/ocean view
Edison Beach House

Edison Beach House

Edison Beach House
3.5 star property
21.2 km from Sanctuary
9.4 out of 10, Exceptional, (1580)
"Awesome stay "
United States
mary
The price is 3.998.664 ₫
5.338.479 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Edison Beach House
Outdoor pool
Casa Ybel Resort

Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
8.8 out of 10, Excellent, (290)
"Room was amazing! Their video on their site is pre Hurricane Ian so don’t expect it to be like that ! Lots of devistation but they are working to bring it back. Most staff was nice , the front office staff were snotty and not helpful at !! Location on the beach is amazing! Sanibel / Captiva have captured my heart and I can’t wait to return. I’d stay there again . "
United States
Arra
The price is 7.602.723 ₫
8.477.037 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Casa Ybel Resort
2 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sundial Beach Resort & Spa

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2584)
"wonderful family friendly and spotless resort"
United States
Mary Anne
The price is 9.446.844 ₫
11.970.514 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Sundial Beach Resort & Spa
Outdoor pool
GullWing Beach Resort

GullWing Beach Resort

GullWing Beach Resort
3.5 star property
27.3 km from Sanctuary
9.4 out of 10, Exceptional, (932)
"The view of the beach was spectacular. "
United States
Carol
GullWing Beach Resort
Exterior
Sanibel Inn

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.0 out of 10, Wonderful, (1001)
"Very nice hotel/resort. Clean, quiet, nice pool, attentive staff. Love the screened in balcony. "
Canada
Jonathan
The price is 7.402.105 ₫
9.778.626 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Sanibel Inn
Exterior
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (1703)
"Great place "
United States
Debra Sue
The price is 4.711.584 ₫
6.573.500 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Margaritaville Beach Resort Fort Myers
View from property
Best Western Plus Beach Resort

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1004)
"Great place to stay."
United States
Michael
The price is 6.024.303 ₫
6.717.229 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Best Western Plus Beach Resort
In-room safe, desk, laptop workspace, blackout curtains
Shalimar Beach Resort

Shalimar Beach Resort

Shalimar Beach Resort
2.0 star property
West End, 10.3 km from Sanctuary
10.0 out of 10, Exceptional, (11)
"Great staff great room great location can’t say enough positive things about this place"
United States
Kenneth
The price is 6.724.069 ₫
7.497.337 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Shalimar Beach Resort
Porch
Angler's Inn

Angler's Inn

Angler's Inn
2.5 star property
18.8 km from Sanctuary
9.4 out of 10, Exceptional, (322)
"Cute Inn in Matlacha. Clean rooms, comfy beds, and a great screened in porch for each room. Town still recovering from Ian, but still a great time. "
United States
Crystal
The price is 4.603.725 ₫
5.133.285 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Angler's Inn
Exterior
Kona Kai Motel

Kona Kai Motel

Kona Kai Motel
Mid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (941)
"Spacious rooms, friendly staff, quiet surroundings."
United States
James
The price is 4.182.813 ₫
4.803.921 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Kona Kai Motel
Exterior
Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1193)
"Friendly staff, fun kid events "
United States
Payge
The price is 5.421.873 ₫
7.776.126 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Pink Shell Beach Resort and Marina
Outdoor pool, open 7:30 AM to 9:30 PM, free pool cabanas, pool loungers
Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (905)
"Wonderful stay at the property. It was hard to leave."
United States
Aaron
Latitude 26 Waterfront Resort & Marina
Exterior
Driftwood Inn

Driftwood Inn

Driftwood Inn
2.0 star property
Mid Island, 13.1 km from Sanctuary
10.0 out of 10, Exceptional, (8)
"Great place to stay on sanibel"
United States
Terri
The price is 8.416.925 ₫
15.708.811 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Driftwood Inn
Aerial view
DiamondHead Beach Resort

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.0 out of 10, Wonderful, (1003)
"Everything about this resort is spectacular! Staff, amenities, room! We had a wonderful stay!"
United States
Minda
DiamondHead Beach Resort
Exterior
Tarpon Tale Inn

Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (392)
"Great staff, close to the beach. Provided beach chairs, umbrella, & beach cart for stay. Highly recommend"
United States
Thomas
The price is 4.445.883 ₫
4.957.291 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Tarpon Tale Inn
Balcony view
Lovers Key Resort

Lovers Key Resort

Lovers Key Resort
3.0 star property
30.3 km from Sanctuary
8.8 out of 10, Excellent, (1016)
"Nice place"
United States
patrick
Lovers Key Resort
2 outdoor pools
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
21.5 km from Sanctuary
8.6 out of 10, Excellent, (1569)
"Great resort fun bar beautiful pool walkable area variety of restaurants and clean beach"
United States
Erika
The Lighthouse Resort Inn & Suites
Economy Studio (Turtle) | Private kitchen
TriLuxe Inn & Studios

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very good, (16)
"Everything was great, will definitely be coming back"
United States
Ruben
The price is 1.525.806 ₫
2.551.911 ₫ total
includes taxes & fees
16 Dec - 17 Dec
TriLuxe Inn & Studios
Deluxe Studio, 1 King Bed, Marina View | View from room
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1005)
"Great Place to Stay!"
United States
JUDY
The price is 2.519.158 ₫
2.809.061 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Suite with King Bed, Beachfront, Balcony | Terrace/patio
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1009)
"Clean rooms, friendly staff, so much to do there and nearby "
United States
Lisa R
The price is 3.779.001 ₫
4.800.232 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Lani Kai Beachfront Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.
Fort Myers featuring a beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Sea School and Dunes Golf and Tennis Club are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Allure Suites

Allure Suites

10/10 Excellent
"Nice people"
Glen 2-night trip
Posted 4 days ago
Allure Suites

Explore a world of travel with Expedia

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 13 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.