Search Hotels in Sanctuary, Sanibel

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,207 reviews)
"Nice place to stay"
United States
Denise
The price is 7.454.839 ₫
8.891.187 ₫ total
includes taxes & fees
10 Feb - 11 Feb
Lani Kai Beachfront Resort

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1,006 reviews)
"Very clean & friendly staff. "
United States
denise
The price is 4.310.356 ₫
4.806.047 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1,226 reviews)
"Nice room, great tiki bar and pool area, and friendly staff."
United States
Jason
The price is 4.284.390 ₫
4.777.095 ₫ total
includes taxes & fees
6 Mar - 7 Mar
Dolphin Key Resort

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.8 out of 10, Good, (1,008 reviews)
"The room was very clean, spacious and the kitchenette was nice! The staff was also very helpful and really nice!!"
United States
Kristin
The price is 2.986.090 ₫
3.329.490 ₫ total
includes taxes & fees
27 Feb - 28 Feb
Allure Suites

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Great stay"
United States
Andrea
The price is 6.192.891 ₫
6.905.138 ₫ total
includes taxes & fees
7 Mar - 8 Mar
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (274 reviews)
"The property was super cute and clean! It also had just about anything you could need!"
United States
Wyatt
The price is 3.248.347 ₫
5.569.707 ₫ total
includes taxes & fees
9 Feb - 10 Feb
Matlacha Tiny Village

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,006 reviews)
"Great stay "
United States
Brandon
The price is 4.769.435 ₫
5.317.919 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Doubletree by Hilton Fort Myers at Bell Tower Shops

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
The price is 6.509.676 ₫
7.647.779 ₫ total
includes taxes & fees
10 Feb - 11 Feb
The Anchor Inn

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (231 reviews)
"Beautiful resort, great communication, super clean "
United States
Ronald
The price is 2.570.634 ₫
4.603.383 ₫ total
includes taxes & fees
5 Mar - 6 Mar
Matlacha on Shoreview

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral

Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral
3.0 star property
23.1 km from Sanctuary
The price is 2.544.668 ₫
8.864.533 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Bike to Dtwn: Home w/ Hot Tub & BBQ in Cape Coral

Lazy Cuckoo Inn

Lazy Cuckoo Inn
2.0 star property
22.1 km from Sanctuary
8.8 out of 10, Excellent, (243 reviews)
"Room was spotless equipped with everything you could need bed was comfy Frank was very helpful"
United States
Judith
The price is 2.752.396 ₫
3.908.533 ₫ total
includes taxes & fees
9 Feb - 10 Feb
Lazy Cuckoo Inn

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,211 reviews)
"Staff was pleasant, breakfast was good."
United States
Lorrin
The price is 4.180.526 ₫
4.661.416 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.4 out of 10, Very good, (18 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is 2.757.589 ₫
3.914.322 ₫ total
includes taxes & fees
9 Feb - 10 Feb
TriLuxe Inn & Studios

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (1,858 reviews)
"Great place!"
United States
Stephanie
The price is 7.688.533 ₫
9.875.688 ₫ total
includes taxes & fees
9 Feb - 10 Feb
Margaritaville Beach Resort Fort Myers

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,007 reviews)
"Clean, friendly, helpful, heated clean pool, great made-to-order breakfasts…OUTSTANDING!!"
United States
Renee Marie
The price is 5.380.155 ₫
5.998.873 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Hilton Garden Inn Ft Myers

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.0 out of 10, Very good, (1,026 reviews)
"Clean room, conveniently located close to Sanibel, comfortable accommodations "
United States
Stacey
The price is 4.549.243 ₫
5.072.405 ₫ total
includes taxes & fees
1 Mar - 2 Mar
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (938 reviews)
"Beautiful clean room friendly staff beautiful scenery"
United States
Cassie
The price is 7.659.970 ₫
8.540.996 ₫ total
includes taxes & fees
7 Mar - 8 Mar
Latitude 26 Waterfront Resort & Marina

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,591 reviews)
"Sweet staff, amazing beach access, pool, restaurant on site. Good value and great stay!"
United States
Freda
The price is 9.841.114 ₫
11.621.992 ₫ total
includes taxes & fees
9 Feb - 10 Feb
Sanibel Island Beach Resort

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (817 reviews)
"Staff were great! "
United States
Karen
The price is 4.180.526 ₫
4.661.286 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"Clean room and friendly staff. "
United States
Cindy
The price is 5.998.146 ₫
6.687.932 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Residence Inn by Marriott Fort Myers Sanibel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodation options in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.