Search Hotels in Sanctuary, Sanibel

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Check prices for these dates

Tonight
9 Dec - 10 Dec
Tomorrow
10 Dec - 11 Dec
This weekend
12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Sanctuary hotels

On the beach, white sand, kayaking, motor boating
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very good, (1004)
"This was thr best place that we have ever stayed at. "
United States
Matthew
The price is 5.509.658 ₫
6.802.318 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Marriott Sanibel Harbour Resort & Spa
Interior entrance
Allure Suites

Allure Suites

3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1006)
"Liked the friendly and fast check-in, spacious and clean suite, great location close to stores, soundproof rooms, greetings when I returned each day and reasonable room rates. I would stay again. "
United States
Charles
Allure Suites
Deluxe Studio, 1 King Bed, Marina View | View from room
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1005)
"Great Place to Stay!"
United States
JUDY
The price is 2.865.022 ₫
3.194.283 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Aerial view
DiamondHead Beach Resort

DiamondHead Beach Resort

3.5 star property
22.3 km from Sanctuary
9.0 out of 10, Wonderful, (1005)
"Everything about this resort is spectacular! Staff, amenities, room! We had a wonderful stay!"
United States
Minda
DiamondHead Beach Resort
Exterior
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

2.5 star property
23.1 km from Sanctuary
9.4 out of 10, Exceptional, (1005)
"Great rooms, good staff"
United States
Dedan
The price is 2.557.114 ₫
2.851.314 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Outdoor pool
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1003)
"Clean room, wonderful staff, and nice breakfast. "
United States
Danielle
The price is 2.504.390 ₫
2.792.395 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Residence Inn by Marriott Fort Myers Sanibel
View from room
Matlacha on Shoreview

Matlacha on Shoreview

2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (208)
"Place was great. Nice and neat perfect for what i needed."
United States
Michael
The price is 1.186.290 ₫
3.086.331 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Matlacha on Shoreview
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

3.0 star property
22.9 km from Sanctuary
8.4 out of 10, Very good, (1003)
"Everything about this stay was wonderful. "
United States
John
The price is 2.720.558 ₫
3.033.423 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Exterior
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3.0 star property
19.9 km from Sanctuary
8.0 out of 10, Very good, (1011)
"Nice staff, clean and convenient. Will stay again. "
United States
Josephine
The price is 2.890.593 ₫
3.223.011 ₫ total
includes taxes & fees
11 Dec - 12 Dec
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Suite with King Bed, Beachfront, Balcony | Terrace/patio
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1020)
"Clean rooms, friendly staff, so much to do there and nearby "
United States
Lisa R
The price is 3.787.045 ₫
4.810.451 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Lani Kai Beachfront Resort
Exterior
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (1693)
"Great place "
United States
Debra Sue
The price is 4.721.434 ₫
6.587.244 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Margaritaville Beach Resort Fort Myers
Lobby
Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa

3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1002)
"Stunning Beach View great Staff "
United States
Robert
The price is 8.409.478 ₫
10.299.238 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Tween Waters Island Resort & Spa
Bar (on property)
Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3.0 star property
21.6 km from Sanctuary
9.2 out of 10, Wonderful, (1013)
"Was great location "
United States
Jose
The price is 3.163.440 ₫
4.186.286 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Matanzas Inn Bayside Resort and Marina
Apartment, Multiple Beds, Partial Ocean View | Beach/ocean view
Edison Beach House

Edison Beach House

3.5 star property
21.2 km from Sanctuary
9.4 out of 10, Exceptional, (1577)
"Great room and view! Very clean and comfortable. Would recommend, a great location!"
United States
Catherine
The price is 4.007.024 ₫
5.349.641 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Edison Beach House
Free buffet breakfast
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1028)
"Hotel was very clean and the breakfast had a great variety."
United States
Lynn
The price is 2.979.019 ₫
3.321.738 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Terrace/patio
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1006)
"Great hotel loved it"
United States
Jacqueline
The price is 2.748.239 ₫
3.064.287 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hilton Garden Inn Ft Myers
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1454)
"Nice location and friendly staff. The access to the beach is easy "
United States
Henrik C
The price is 5.509.658 ₫
6.802.319 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Sanibel Island Beach Resort
Outdoor pool, open 8:00 AM to 10:00 PM, pool cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1003)
"Excellent stay over Thanksgiving holiday!"
United States
Nicole
The price is 3.856.380 ₫
5.301.600 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Westin Cape Coral Resort At Marina Village
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
South Seas Resort

South Seas Resort

3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very good, (1003)
"Great family moments created in this place "
United States
Denis
South Seas Resort
Exterior
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG

3.0 star property
25.4 km from Sanctuary
7.4 out of 10, Good, (1003)
"Great place to stay."
United States
David
The price is 2.161.766 ₫
2.410.369 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.
Fort Myers featuring a beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Sea School and Dunes Golf and Tennis Club are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Allure Suites

Allure Suites

10/10 Excellent
"Very clean and comfortable suite. The staff were friendly and accommodating. I actually extended my stay bc I felt so at home. It may be a little worn in some ways but I didn’t mind bc everything was spotless and whatever they spray on their linens smells fantastic! "
Audra 1-night trip
Posted 3 weeks ago
Allure Suites

Explore a world of travel with Expedia

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 13 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.