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20 Dec - 21 Dec
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21 Dec - 22 Dec
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Our top choices for Sanctuary hotels

Exterior
Kona Kai Motel

Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (941)
"Spacious rooms, friendly staff, quiet surroundings."
United States
James
The price is 4.184.085 ₫
4.805.382 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Kona Kai Motel
View from room
Matlacha on Shoreview

Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (212)
"Place was great. Nice and neat perfect for what i needed."
United States
Michael
The price is 1.447.325 ₫
3.374.241 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Matlacha on Shoreview
Outdoor pool, open 8:00 AM to 10:00 PM, pool cabanas (surcharge)
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1004)
"Excellent stay over Thanksgiving holiday!"
United States
Nicole
The price is 3.849.358 ₫
5.292.004 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Westin Cape Coral Resort At Marina Village
Balcony view
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1003)
"Beautiful place "
United States
Blaine
The price is 1.902.232 ₫
2.305.195 ₫ total
includes taxes & fees
30 Dec - 31 Dec
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
Exterior
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.6 out of 10, Excellent, (1002)
"The rooms were clean, staff were very friendly and accommodating."
United States
Sandra
The price is 3.210.430 ₫
3.579.630 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
Terrace/patio
Dolphin Key Resort

Dolphin Key Resort

Dolphin Key Resort
3.0 star property
23.8 km from Sanctuary
8.8 out of 10, Excellent, (1208)
"Nice room, helpful staff, nice heated pool, bar/restaurant on site has good prices and live entertainment most nights. Overall, a fun place to stay."
United States
Jacob
The price is 2.631.500 ₫
2.934.123 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Dolphin Key Resort
Free buffet breakfast
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1062)
"Is great place to stay."
United States
Anastassia
The price is 3.131.485 ₫
3.491.607 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Exterior
Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (144)
"great boutique hotel in an amazing area on Pine Island Fl. Great restaurants and bars walkable and great fishing. "
United States
Pat
The price is 5.002.429 ₫
6.457.944 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Off the Charts Inn & Out Island Resort
Outdoor pool, a heated pool, pool loungers
Resort Harbour Properties

Resort Harbour Properties

Resort Harbour Properties
3.5 star property
15.7 km from Sanctuary
9.6 out of 10, Exceptional, (364)
"10/10 would stay there again"
United States
Kristie
Resort Harbour Properties
Deluxe Studio Suite | Terrace/patio
White Orchid Apartments

White Orchid Apartments

White Orchid Apartments
2.0 star property
20 km from Sanctuary
8.0 out of 10, Very good, (49)
"Place was nice and private. "
United States
Dawn
The price is 1.631.530 ₫
2.670.052 ₫ total
includes taxes & fees
21 Dec - 22 Dec
White Orchid Apartments
Basic Studio | Private kitchen | Dining tables
Summerwind Studios

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.0 out of 10, Very good, (11)
"Very clean and roomy. Quiet neighborhood. Loves the shower; so relaxing. Only complaint is that we could have used some drinking glasses. I would stay here again. "
United States
Micki
The price is 1.578.900 ₫
2.611.369 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Summerwind Studios
Economy Studio (Turtle) | Private kitchen
TriLuxe Inn & Studios

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very good, (17)
"Everything was great, will definitely be coming back"
United States
Ruben
The price is 1.526.792 ₫
2.553.560 ₫ total
includes taxes & fees
22 Dec - 23 Dec
TriLuxe Inn & Studios
Outdoor pool
Sanibel Island Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1477)
"Great place."
United States
Michael
The price is 6.710.325 ₫
8.139.887 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sanibel Island Beach Resort
On the beach, white sand, kayaking, motor boating
Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.4 out of 10, Very good, (1002)
"This was thr best place that we have ever stayed at. "
United States
Matthew
The price is 5.236.685 ₫
6.496.780 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Marriott Sanibel Harbour Resort & Spa
Exterior
Sanibel Inn

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.0 out of 10, Wonderful, (1000)
"Very nice hotel/resort. Clean, quiet, nice pool, attentive staff. Love the screened in balcony. "
Canada
Jonathan
The price is 9.279.621 ₫
11.872.521 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Sanibel Inn
Outdoor pool
Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.6 out of 10, Excellent, (1002)
"The property was clean and the breakfast was excellent the staff was friendly and convenient to Sanibel Island"
United States
robert
The price is 2.710.445 ₫
3.022.146 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn by Marriott Fort Myers Sanibel
Exterior
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
25.4 km from Sanctuary
7.4 out of 10, Good, (1003)
"Great place to stay."
United States
David
The price is 2.447.295 ₫
2.728.734 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Lobby lounge
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (787)
"Clean room and very nice staff "
United States
Michael
The price is 2.262.498 ₫
2.522.686 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
Luxury Suite, Sea View | Beach/ocean view
Island Inn

Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1122)
"Really nice, updated, and clean room with a screened waterfront balcony in a perfect place on the island (far enough away from the big resorts to be in a quieter area, but close enough to the center area of the island to be convenient). "
United States
Chris
The price is 6.817.916 ₫
7.601.977 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Island Inn
Exterior
Tarpon Tale Inn

Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 14.8 km from Sanctuary
9.6 out of 10, Exceptional, (392)
"Great staff, close to the beach. Provided beach chairs, umbrella, & beach cart for stay. Highly recommend"
United States
Thomas
The price is 5.894.560 ₫
6.572.434 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Tarpon Tale Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.
Fort Myers featuring a beach
Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography
Open Photo by Sanibel Captiva Chamber of Commerce/Milissa Sprecher Photography

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Sea School and Dunes Golf and Tennis Club are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Allure Suites

Allure Suites

10/10 Excellent
"Yes"
Robert B. 7-night trip
Posted 7 days ago
Allure Suites

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 12 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.