Search Hotels Near Sanford USD Medical Center, Sioux Falls

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
10 Dec - 11 Dec
Tomorrow
11 Dec - 12 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanford USD Medical Center hotels

Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.1 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (584)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is 2.720.558 ₫
3.037.175 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
9.6 out of 10, Exceptional, (1295)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.4 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (152)
"Room was very clean, great overall stay."
United States
Destiny
The price is 3.653.246 ₫
4.165.782 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Canopy By Hilton Sioux Falls Downtown
Free daily continental breakfast
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.9 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1000)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Presidential Suite, 1 King Bed, Jetted Tub (Balcony) | Living area | 42-inch LCD TV with cable channels, TV, pay films
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2 km from Sanford USD Medical Center
9.0 out of 10, Wonderful, (881)
"Under construction but staff adapted and accommodated very well. Room was clean and quiet. Perfect location "
United States
Joseph
The price is 2.885.430 ₫
3.323.489 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Hilton Garden Inn Sioux Falls Downtown
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.4 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is 3.308.674 ₫
4.061.955 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Historic Victorian Inn
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1005)
"Always a great stay. "
United States
Shawn
The price is 2.398.942 ₫
3.198.501 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Sioux Falls-City Centre by IHG
Exterior
Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD
3.0 star property
Downtown Sioux Falls, 1.9 km from Sanford USD Medical Center
8.4 out of 10, Very good, (1154)
"It was a great place to stay!"
United States
Trinity
The price is 2.555.253 ₫
2.855.852 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Country Inn & Suites by Radisson, Sioux Falls, SD
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.8 km from Sanford USD Medical Center
8.6 out of 10, Excellent, (1000)
"Great hotel. Staff was excellent "
United States
Kristina
The price is 2.555.253 ₫
2.855.853 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton Sioux Falls Hotel & Convention Center
Free daily continental breakfast
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.3 km from Sanford USD Medical Center
8.4 out of 10, Very good, (699)
"Clean room and friendly staff."
United States
Betty
The Center Inn
Room, 2 Queen Beds | Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.1 km from Sanford USD Medical Center
7.6 out of 10, Good, (1003)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.8 out of 10, Good, (1451)
"Great staff "
United States
Eric
The price is 1.577.766 ₫
1.783.532 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Dining room
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.3 km from Sanford USD Medical Center
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveller
The price is 7.096.167 ₫
8.046.878 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Historic Twin Tudors Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 2.9 km from Sanford USD Medical Center
7.0 out of 10, Good, (51)
"Great "
United States
Jorge
Ramada by Wyndham Sioux Falls Arpt & Suites
Front of property
WoodSpring Suites Sioux Falls

WoodSpring Suites Sioux Falls

WoodSpring Suites Sioux Falls
2.5 star property
2.9 km from Sanford USD Medical Center
5.2 out of 10, (60)
"The price was good, the cleanliness was better than other cheap hotels I've stayed in. My primary complaint was the slow internet speeds. There was also damage that had not been repaired from prior guests."
United States
Trent
The price is 1.818.978 ₫
2.048.327 ₫ total
includes taxes & fees
14 Dec - 15 Dec
WoodSpring Suites Sioux Falls
Double Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout curtains
Highpoint Hotel

Highpoint Hotel

Highpoint Hotel
3.0 star property
University Heights, 0.3 km from Sanford USD Medical Center
The price is 4.436.725 ₫
4.919.811 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Highpoint Hotel
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.7 km from Sanford USD Medical Center
5.6 out of 10, (1007)
"Good room for the price."
United States
Michael
The price is 1.254.831 ₫
1.429.274 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Ramada by Wyndham Sioux Falls
Front of property – evening/night
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 3.2 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (1003)
"Great location and a friendly staff "
United States
Dan
The price is 2.572.404 ₫
2.874.652 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Hampton Inn Sioux Falls
Exterior
Holiday Inn & Suites Sioux Falls - Airport by IHG

Holiday Inn & Suites Sioux Falls - Airport by IHG

Holiday Inn & Suites Sioux Falls - Airport by IHG
3.0 star property
Northwest Sioux Falls, 3.3 km from Sanford USD Medical Center
9.2 out of 10, Wonderful, (836)
"Loved that we got a free breakfast meal voucher for the restaurant attached!"
United States
Makella
The price is 2.609.838 ₫
2.915.901 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn & Suites Sioux Falls - Airport by IHG
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South
3.0 star property
Mall District, 3.8 km from Sanford USD Medical Center
9.4 out of 10, Exceptional, (1002)
"Great location for travel. Various dining options close by."
United States
Russell
The price is 3.179.257 ₫
3.540.368 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Place Sioux Falls South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sanford USD Medical Center Hotel Reviews

Hotels near other Sanford USD Medical Center attractions

Sioux Empire Medical Museum

You can spend time studying the exhibits at Sioux Empire Medical Museum during your travels in Sioux Falls. In the area, take in the entertainment choices and beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
See properties

Frequently asked questions

What's the area like around Sanford USD Medical Center?
Sanford USD Medical Center is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 112 hotels and other accommodation options you'll find within a mile.
How many hotels should I expect to find close to Sanford USD Medical Center?
Expedia has 112 hotels and other accommodation options within a mile from Sanford USD Medical Center.
If I need to cancel the hotel reservation for my stay near Sanford USD Medical Center, will I receive a refund?
Yes! Most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of your booking. Add dates, click "Search", then you can use the "fully refundable" filter to get the best deals near Sanford USD Medical Center.
What can I see and do near Sanford USD Medical Center?
Study the collections at Washington Pavilion of Arts and Science, Center for Western Studies or Pettigrew Home and Museum. Spend some time wandering around Falls Park, Sherman Park and Veterans' Memorial Park. Create some family memories at Delbridge Museum of Natural History, Great Plains Zoo and Thunder Road Family Fun Park while you're exploring the area around Sanford USD Medical Center.

Explore a world of travel with Expedia