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12 Dec - 13 Dec
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13 Dec - 14 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Santa Ana hotels

Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (54)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
Apartment (20) | Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is 2.134.917 ₫
3.073.227 ₫ total
includes taxes & fees
14 Dec - 15 Dec
La Manzana by Wynwood House
Living area
Hostal La Cigarra

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is 667.703 ₫
734.579 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Hostal La Cigarra
Double Room | View from room
Hotel República

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
5.8 out of 10, (10)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Room, Multiple Bedrooms, Accessible, Smoking | Exterior
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is 3.885.619 ₫
4.274.181 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Room-sofa Bed Stay Rooftop Pool & Gym, A
Apartment | Living area | 40-inch Smart TV with cable channels
Casa Quijano 06 By Wynwood House

Casa Quijano 06 By Wynwood House

Casa Quijano 06 By Wynwood House
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (4)
"Easy to find, seamless check-in "
Canada
Matthew
The price is 2.741.128 ₫
3.885.022 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Casa Quijano 06 By Wynwood House
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
7.5 km from Santa Ana
8.0 out of 10, Very good, (1002)
"Our stay was very nice, the service the hotel provides is wonderful, I highly recommend it"
United States
Mayra Alexandra Montes
The price is 5.239.471 ₫
5.763.418 ₫ total
includes taxes & fees
17 Dec - 18 Dec
The Westin Playa Bonita Panama
Outdoor pool, pool loungers
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1002)
"Amazing amazing service"
United States
KFIR
The price is 4.186.311 ₫
4.604.942 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Room, 1 King Bed, Balcony, Oceanfront (Magnifique) | Premium bedding, down duvets, pillow-top beds, minibar
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (555)
"Great hotel and location "
United Kingdom
Russell
The price is 10.081.553 ₫
11.089.708 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Sofitel Legend Casco Viejo, Panama City
Exterior
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.0 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (35)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is 3.159.480 ₫
4.101.005 ₫ total
includes taxes & fees
13 Dec - 14 Dec
ORHO HOTEL BOUTIQUE PANAMA Airport
View from property
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (638)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is 6.101.746 ₫
6.711.921 ₫ total
includes taxes & fees
20 Dec - 21 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.4 out of 10, Very good, (1265)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is 3.222.719 ₫
3.544.991 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Megapolis Hotel Panamá
Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4647)
"Awesome great place to stay "
United States
Herbert
The price is 3.373.937 ₫
3.711.331 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hotel Riu Plaza Panama
Lobby
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Campo Alegre, 3.3 km from Santa Ana
10.0 out of 10, Exceptional, (121)
"Great hotel fair price"
United States
Santiago
The price is 3.554.415 ₫
3.909.857 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Hyatt Regency Panama City
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is 8.490.908 ₫
9.339.999 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hotel La Compañía Casco Antiguo
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.4 out of 10, Exceptional, (157)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is 1.739.562 ₫
3.131.211 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Arcadia Condo Suites
Front of property
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1002)
"Excellent hotel , good breakfast, great location, would highly recommend "
United States
Glen
The price is 5.265.067 ₫
5.791.574 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Central Hotel Panama Casco Viejo
2 bars/lounges, poolside bar
Waldorf Astoria Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista, 2.9 km from Santa Ana
9.0 out of 10, Wonderful, (1001)
"I loved everything about my stay "
United States
Stephanie
The price is 4.733.190 ₫
5.206.509 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Waldorf Astoria Panama
Food and drink
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.6 km from Santa Ana
8.8 out of 10, Excellent, (1004)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is 2.663.178 ₫
2.929.495 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott Panama Metromall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
How many hotels can I expect to find in Santa Ana?
Expedia has 112 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.