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Check prices for these dates

Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

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Our top choices for Santa Ana hotels

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

1. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (106 reviews)
"Amazing location and comfort"
United States
Ruben
The price is 2.054.272 ₫
3.039.309 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Casco View Life Residences
A hotel corridor with a wooden railing, doors, and wall-mounted plants.

2. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
8.0 out of 10, Very good, (19 reviews)
"great staff"
United States
Keith
The price is 1.001.019 ₫
1.101.069 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Hotel Caracas - Casco Viejo
A hotel room with a large bed, a window with curtains, a city view, and a lamp.

3. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is 760.120 ₫
2.395.482 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Hotel República
A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.

4. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (75 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is 763.073 ₫
839.380 ₫ total
includes taxes & fees
14 Oct - 15 Oct
Hostal La Cigarra
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

5. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (19 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is 1.855.472 ₫
2.755.662 ₫ total
includes taxes & fees
11 Oct - 12 Oct
La Manzana Barrio Vivo by Wynwood
A hotel entrance with a green facade and a metal fence.

6. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (13 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is 956.795 ₫
1.052.474 ₫ total
includes taxes & fees
4 Nov - 5 Nov
ART CASCO The Hotel
A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

7. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is 701.649 ₫
771.814 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Hotel Riazor
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

8. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (6,003 reviews)
"Clean rooms, amazing staff and good breakfast"
United States
Avanel
The price is 3.576.889 ₫
3.934.578 ₫ total
includes taxes & fees
25 Oct - 26 Oct
Hotel Riu Plaza Panama
A modern lobby with a chandelier, seating area, reception desk, and a staircase.

9. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,272 reviews)
"great location, great hotel"
United States
Sandra
The price is 2.305.035 ₫
2.535.538 ₫ total
includes taxes & fees
27 Oct - 28 Oct
The Executive Hotel
A high-rise building with a modern architectural design, featuring a grid of windows and balconies.

10. Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.6 out of 10, Excellent, (1,760 reviews)
"Hotel was amazing"
United States
Sheena
The price is 4.174.084 ₫
4.591.492 ₫ total
includes taxes & fees
26 Oct - 27 Oct
Megapolis Hotel Panamá
A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

11. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (457 reviews)
"The hotel was a great surprise. Great friendly knowledgeable staff. Super modern room with great decor. Massive comfortable bed."
United States
Eric
The price is 3.977.938 ₫
4.375.732 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Hotel San Felipe
A covered outdoor seating area with a view of a city skyline and water.

12. Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,233 reviews)
"Great location close to all the areas of Panama City. Hotel staff was helpful and the buffet breakfast great"
United States
Jennifer
The price is 2.815.768 ₫
2.815.768 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Plaza Paitilla Inn Hotel
A multi-story building with balconies, arched windows, and decorative railings.

13. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1,005 reviews)
"Great location and nice hotel."
United States
Olga
The price is 4.942.444 ₫
5.436.688 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Central Hotel Panama Casco Viejo
A hotel named PRINCIPE with a modern facade and large glass windows.

14. Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (2,083 reviews)
"Ok for a short stay"
United States
Dayami
The price is 1.536.611 ₫
1.690.194 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Principe Hotel and Suites
A balcony with a table, chairs, and a view of a city skyline across a body of water.

15. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (755 reviews)
"Amazing service and beautiful hotel"
United States
Jose
The price is 9.121.437 ₫
10.033.581 ₫ total
includes taxes & fees
3 Nov - 4 Nov
Sofitel Legend Casco Viejo, Panama City
A rooftop pool with sun loungers and a city skyline in the background.

16. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,179 reviews)
"Breakfast was excellent"
United States
kevin
The price is 2.319.340 ₫
3.980.689 ₫ total
includes taxes & fees
8 Oct - 9 Oct
Waymore Hotel Spa & Casino
A restaurant with multiple dining tables, chairs, and a central water feature.

17. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
San Felipe, 0.9 km from Santa Ana
9.8 out of 10, Exceptional, (354 reviews)
"It was a romantic outing for me and my loved one, we had a nice Spa treatment then a wonderful dinner experience at the hotels special restaurant Villa Ana and its rooftop bar Atico. Breakfast was very nice! Wonderful stay!"
United States
Eduardo
The price is 6.825.486 ₫
7.508.035 ₫ total
includes taxes & fees
9 Oct - 10 Oct
Hotel La Compañía Casco Antiguo
A conference room with a large table, chairs, a potted plant, and a curtain backdrop.

18. Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1,033 reviews)
"It was an amazing place and center located to all restaurants and night life"
United States
Abraham
The price is 1.929.911 ₫
2.122.902 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Riande Urban Hotel
A spacious indoor area with high ceilings, large windows, and multiple dining tables.

19. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (818 reviews)
"Beautiful hotel"
United States
Ashleigh-Ann
The price is 4.658.170 ₫
5.123.987 ₫ total
includes taxes & fees
12 Oct - 13 Oct
American Trade Hotel
A balcony with wicker chairs and a view of the cityscape.

20. Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1,367 reviews)
"excellent breakfast great location"
United States
Maria
The price is 2.716.941 ₫
2.988.635 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Ramada Plaza by Wyndham Panama Punta Pacifica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
106 reviews
View
A hotel corridor with a wooden railing, doors, and wall-mounted plants.
Hotel Caracas - Casco Viejo
3.0 star property
8.0
Very good
19 reviews
View
A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.
Hostal La Cigarra
2.0 star property
7.6
Good
75 reviews
View
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
19 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

8/10 Good
"Friendlystaff"
Julio 1-night trip
Posted less than an hour ago
Courtyard by Marriott Panama Metromall

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
How many hotels can I expect to find in Santa Ana?
Expedia has 135 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.

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