Santa Clara Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is 3.406.254 ₫ per night from 5 May to 6 May
3.406.254 ₫
3.746.879 ₫ total
5 May - 6 May
includes taxes & fees
9/10 Wonderful! (5,265 reviews)
My number one Hotel in Panama City ! Close to everything and Uber is cheap

Reviewed on 10 Apr 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is 3.343.402 ₫ per night from 4 May to 5 May
3.343.402 ₫
3.851.494 ₫ total
4 May - 5 May
includes taxes & fees
8.6/10 Excellent! (2,504 reviews)
Shuttle was small and we had to wait an hour

Reviewed on 9 Apr 2026

Crowne Plaza Panama Airport by IHG
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is 3.334.188 ₫ per night from 1 May to 2 May
3.334.188 ₫
3.667.607 ₫ total
1 May - 2 May
includes taxes & fees
8.6/10 Excellent! (1,003 reviews)
Fresh breakfast each morning

Reviewed on 9 Apr 2026

Sheraton Grand Panama
See all 1,372 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Clara holiday package cost?
Custom make your Santa Clara holiday package from as little as . Pick from any combination of hotels, flights and rental cars to craft the escape of your dreams. Be sure to add on some tours and experiences!
How do I get a cheap travel package to Santa Clara?
One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all. Select the combination that best fits you and watch your savings grow. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 air carriers and 1null000null000 hotels throughout the world, which lets you customize your Santa Clara getaway.
Where should I stay in Santa Clara?
Most travellers who visit Santa Clara include Miraflores Locks and Metropolitan Cathedral of Panama on their must-see lists. Why not select a hotel close to one of these main attractions?
How far in advance should I book my Santa Clara holiday?
Savvy travellers always book early. Air carriers generally advertise flights up to a year prior to departure, and this is a fantastic opportunity to score some of the cheapest prices. Just been told you should take some holiday time next week? No need to worry. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at an affordable price.
What does an Expedia Santa Clara travel package include?
It comes down to what you're looking for. If you're travelling solo, you might decide to combine hotels and flights. Bringing the whole family to Santa Clara? A travel package including flights, hotels and rental cars might suit you better. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking a Santa Clara travel package?
When you book your flights, hotels and car rentals together, you'll pick up awesome discounts. Whether you're organising a beach break in a villa or prefer to stay in an upscale city hotel, Expedia can make it happen for less.
Can I choose my airline with a Santa Clara Expedia holiday package?
Yes, you can. We offer more than 550 airline partners throughout the world, so opt for the carrier that fits your budget and travel needs.
If I'm not able to travel, can I cancel my Santa Clara holiday package?
Because we understand life is full of surprises, the answer is yes. For further details, check out our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for no charge. Your hotel, airline or car rental company may impose a fee if you made your booking a while ago.

Popular places to visit

Multiplaza Pacific Mall

Multiplaza Pacific Mall

4.5/5(8 reviews)

During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Causeway, Amador, Panama

Amador Causeway

4.5/5(7 reviews)

You can learn about the history of Ancon with a visit to Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.

Amador Causeway
Panama City night skyline

Avenida Balboa

3.5/5(9 reviews)

You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa