Search Hotels in Santa Clara, Panama City

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12 Dec - 13 Dec
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13 Dec - 14 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Santa Clara hotels

Exterior
Taboga Palace Spa Hotel

Taboga Palace Spa Hotel

Taboga Palace Spa Hotel
3.5 star property
28.1 km from Santa Clara
9.0 out of 10, Wonderful, (38)
"One of the nicest buildings on the Island and right to the Ferry. David the owner was super nice and helpful. Had beautiful views from the room and a private balcony. Overall great place to stay on a visit to the Island."
United States
Malcolm
The price is 3.419.910 ₫
3.761.901 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
Taboga Palace Spa Hotel
Aerial view
Hotel Latino

Hotel Latino

Hotel Latino
3.0 star property
Calidonia, 9.9 km from Santa Clara
6.6 out of 10, (218)
"I was given room key attached to a piece of plastic. It was difficult to tell exactly which room number it was. I unlocked what I thought was my room and saw someone laying in bed unaware I opened the door slightly. I closed the door and asked a housekeeper which room I was in. She told me. When I entered my room the overpowering smell of moth balls was present. I found a room elsewhere and left after an hour. Staff was nice, I didn’t feel the need to go complain but I didn’t feel secure since...
United States
Paul Andrew
Hotel Latino
Ecotours
Hotel Pension Corona

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 9.9 km from Santa Clara
7.8 out of 10, Good, (108)
"Great spot for the price "
United States
frank
Hotel Pension Corona
Terrace/patio
Tantalo Hotel

Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 11.5 km from Santa Clara
8.8 out of 10, Excellent, (274)
"My favorite place in Casco Viejo. "
United States
Michael
Tantalo Hotel
Double Room | Free WiFi, bed sheets
Hotel Discovery

Hotel Discovery

Hotel Discovery
2.5 star property
Calidonia, 10.1 km from Santa Clara
7.4 out of 10, Good, (168)
"Rooms was nice and clean. Transportation was easy area was peaceful. "
United States
Roniald
The price is 717.392 ₫
789.210 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hotel Discovery
Interior detail
Canova

Canova

Canova
3.0 star property
Calidonia, 10.4 km from Santa Clara
8.2 out of 10, Very good, (128)
"The staff was very accommodating and friendly. Excellent service."
United States
Aggrey
The price is 759.962 ₫
835.958 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Canova
Living area
Magnolia Inn

Magnolia Inn

Magnolia Inn
2.0 star property
San Felipe, 11.6 km from Santa Clara
8.8 out of 10, Excellent, (411)
"Excelent location , friendly staff and cute hotel"
Canada
Renata
The price is 1.683.858 ₫
1.852.244 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Magnolia Inn
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
19.1 km from Santa Clara
8.0 out of 10, Very good, (1002)
"Our stay was very nice, the service the hotel provides is wonderful, I highly recommend it"
United States
Mayra Alexandra Montes
The price is 5.235.093 ₫
5.758.602 ₫ total
includes taxes & fees
15 Dec - 16 Dec
The Westin Playa Bonita Panama
Front of property
Hotel California Panama

Hotel California Panama

Hotel California Panama
3.0 star property
Bella Vista, 9.5 km from Santa Clara
7.8 out of 10, Good, (85)
"Excellent front desk service"
United States
JOSEPH
The price is 1.010.189 ₫
1.111.208 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hotel California Panama
Classic Double Room, 1 Double Bed, Non Smoking | In-room safe, desk, soundproofing, free WiFi
Hotel Acapulco

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 10.4 km from Santa Clara
7.8 out of 10, Good, (123)
"Excelente"
United States
Alejandro
The price is 709.623 ₫
780.585 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hotel Acapulco
Reception
Residencial & Hotel Palazzo

Residencial & Hotel Palazzo

Residencial & Hotel Palazzo
3.0 star property
Calidonia, 10.3 km from Santa Clara
7.4 out of 10, Good, (121)
"I recommend this place"
United States
Crystal
Residencial & Hotel Palazzo
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 2.8 km from Santa Clara
9.4 out of 10, Exceptional, (160)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is 1.736.262 ₫
3.125.271 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Arcadia Condo Suites
Poolside bar
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

Gamboa Rainforest Reserve
3.5 star property
25.7 km from Santa Clara
7.8 out of 10, Good, (663)
"Beautiful place to stay for one night. A little over priced for Panama but the service and the food were excellent. "
Canada
Dan
The price is 3.291.006 ₫
3.620.107 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Gamboa Rainforest Reserve
Outdoor pool
Villa Caprichosa

Villa Caprichosa

Villa Caprichosa
3.0 star property
28.6 km from Santa Clara
9.8 out of 10, Exceptional, (42)
"We loved the place and the attention given by the staff."
United States
Juan Carlos
The price is 6.582.250 ₫
7.240.475 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Villa Caprichosa
Terrace/patio
Hotel San Felipe

Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 11.6 km from Santa Clara
9.4 out of 10, Exceptional, (247)
"Really nice staff and property is in amazing location "
United States
Michael
The price is 3.198.973 ₫
3.518.870 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hotel San Felipe
Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
10.2 km from Santa Clara
8.4 out of 10, Very good, (2319)
"Spacious room, clean, good breakfast "
United States
Juan
The price is 2.896.190 ₫
3.185.809 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Crowne Plaza Panama Airport by IHG
Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
8.7 km from Santa Clara
8.6 out of 10, Excellent, (1851)
"Clean room and friendly staff "
United States
Delcides
The price is 3.289.704 ₫
3.618.674 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Riande Aeropuerto Hotel & Casino
Outdoor pool, pool umbrellas, pool loungers
Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG
3.5 star property
12.6 km from Santa Clara
8.6 out of 10, Excellent, (443)
"The staff was so cordial and nice "
United States
Sonny
The price is 2.327.484 ₫
2.994.661 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Panama Canal by IHG
Restaurant
Hotel Costa Inn

Hotel Costa Inn

Hotel Costa Inn
3.0 star property
Calidonia, 9.7 km from Santa Clara
7.0 out of 10, Good, (537)
"Nice stay "
United States
AYESHA
Hotel Costa Inn
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
San Felipe, 11.5 km from Santa Clara
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is 8.477.938 ₫
9.325.732 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hotel La Compañía Casco Antiguo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Clara

Find the best Santa Clara areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Clara Hotel Reviews

Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"The hotel was stunning and christmas festive. It smelled great. The room was beautiful, the hospitality was great. I was suprised with a birthday treat to my door and a card which was super sweet and an excellent touch. Everything was clean. Room service made my bed and changed my towels everyday. Staff was kind and helpful even with the language barrier( I practiced communicating in Spanish). Check-in and check- out was easy and quick. My birthday accommodations were amazing. I was very thankful and comfortable. "
Re'neisha 4-night trip
Posted 7 days ago
Hyatt Regency Panama City

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Frequently asked questions

What is Santa Clara like?
Travellers will be sure to find plenty to entertain them in Panama City's Santa Clara neighbourhood.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals in Santa Clara.
What are the top things to see and do in Santa Clara?
A few places to visit in the area around Santa Clara include Estadio Rommel Fernandez, Plaza de Francia and Atrio Mall. While you're out sightseeing, Monte Oscuro and Los Pueblos Commercial Center are a couple of additional sights to visit in Panama City.