Search Hotels in Santa Clara, Panama City

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Clara hotels

Restaurant
Hotel Lisboa

Hotel Lisboa

Hotel Lisboa
3.0 star property
Calidonia, 10.2 km from Santa Clara
7.6 out of 10, Good, (46)
"Rather old facility but adequate for price, hot water was great, hard to find in much of Central America "
United States
dickie
Hotel Lisboa
Breakfast, lunch, dinner served; Fusion cuisine
Tantalo Hotel

Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 11.5 km from Santa Clara
8.8 out of 10, Excellent, (274)
"My favorite place in Casco Viejo. "
United States
Michael
Tantalo Hotel
Ecotours
Hotel Pension Corona

Hotel Pension Corona

Hotel Pension Corona
2.5 star property
Calidonia, 9.9 km from Santa Clara
7.8 out of 10, Good, (108)
"Great spot for the price "
United States
frank
Hotel Pension Corona
Aerial view
Hotel Latino

Hotel Latino

Hotel Latino
3.0 star property
Calidonia, 9.9 km from Santa Clara
6.6 out of 10, (219)
"I was given room key attached to a piece of plastic. It was difficult to tell exactly which room number it was. I unlocked what I thought was my room and saw someone laying in bed unaware I opened the door slightly. I closed the door and asked a housekeeper which room I was in. She told me. When I entered my room the overpowering smell of moth balls was present. I found a room elsewhere and left after an hour. Staff was nice, I didn’t feel the need to go complain but I didn’t feel secure since...
United States
Paul Andrew
Hotel Latino
Double Room | In-room safe, desk, free WiFi, bed sheets
Hotel Montreal

Hotel Montreal

Hotel Montreal
3.5 star property
Bella Vista, 9 km from Santa Clara
6.0 out of 10, (397)
"Friendly staff alright room"
Canada
Ryan
Hotel Montreal
Lobby
Residencial & Hotel Palazzo

Residencial & Hotel Palazzo

Residencial & Hotel Palazzo
3.0 star property
Calidonia, 10.3 km from Santa Clara
7.4 out of 10, Good, (121)
"I recommend this place"
United States
Crystal
Residencial & Hotel Palazzo
Living area
Magnolia Inn

Magnolia Inn

Magnolia Inn
2.0 star property
San Felipe, 11.6 km from Santa Clara
8.8 out of 10, Excellent, (415)
"Excelent location , friendly staff and cute hotel"
Canada
Renata
The price is 2.513.942 ₫
2.765.336 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Magnolia Inn
Outdoor pool
Hotel California Panama

Hotel California Panama

Hotel California Panama
3.0 star property
Bella Vista, 9.5 km from Santa Clara
7.8 out of 10, Good, (85)
"Excellent front desk service"
United States
JOSEPH
The price is 1.010.496 ₫
1.111.546 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel California Panama
Classic Double Room, 1 Double Bed, Non Smoking | In-room safe, desk, soundproofing, free WiFi
Hotel Acapulco

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 10.4 km from Santa Clara
7.8 out of 10, Good, (124)
"Excelente"
United States
Alejandro
The price is 855.567 ₫
941.124 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Hotel Acapulco
Interior detail
Canova

Canova

Canova
3.0 star property
Calidonia, 10.4 km from Santa Clara
8.2 out of 10, Very good, (130)
"Very close place to everything. Very affordable. "
United States
Alex
The price is 736.765 ₫
810.442 ₫ total
includes taxes & fees
20 Jan - 21 Jan 2026
Canova
Lobby
Metro Hotel Panama

Metro Hotel Panama

Metro Hotel Panama
3.5 star property
El Cangrejo, 8.1 km from Santa Clara
7.8 out of 10, Good, (405)
"This is a a convenient hotel, located in a prime area in the city. The staff is friendly, helpful and the room is cleaned every day. "
United States
Warren
Metro Hotel Panama
Local cuisine
Hotel Vía España

Hotel Vía España

Hotel Vía España
3.0 star property
Calidonia, 9.4 km from Santa Clara
6.2 out of 10, (169)
"Nice hotel conveniently placed but lots of traffic noise"
United Kingdom
Peter
Hotel Vía España
Double Room | Free WiFi, bed sheets
Hotel Discovery

Hotel Discovery

Hotel Discovery
2.5 star property
Calidonia, 10.1 km from Santa Clara
7.4 out of 10, Good, (168)
"Rooms was nice and clean. Transportation was easy area was peaceful. "
United States
Roniald
The price is 717.610 ₫
789.450 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel Discovery
Aerial view
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

Gamboa Rainforest Reserve
3.5 star property
25.7 km from Santa Clara
7.8 out of 10, Good, (665)
"Beautiful place to stay for one night. A little over priced for Panama but the service and the food were excellent. "
Canada
Dan
The price is 3.766.964 ₫
4.143.660 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Gamboa Rainforest Reserve
Interior
Villa Caprichosa

Villa Caprichosa

Villa Caprichosa
3.0 star property
28.6 km from Santa Clara
9.8 out of 10, Exceptional, (42)
"We loved the place and the attention given by the staff."
United States
Juan Carlos
The price is 6.578.750 ₫
7.236.625 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Villa Caprichosa
Outdoor pool
Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 8 km from Santa Clara
7.4 out of 10, Good, (268)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is 2.236.775 ₫
2.460.453 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Ramada Panama Centro Via Argentina
Outdoor spa tub
Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 8.4 km from Santa Clara
8.6 out of 10, Excellent, (1000)
"Stay was ok "
United States
suhail
The price is 2.481.505 ₫
2.729.655 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton Garden Inn Panama City Downtown, Panama
Terrace/patio
Toscana Inn

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 8 km from Santa Clara
9.0 out of 10, Wonderful, (727)
"Friendly staff clean room’s walk able to shops"
United States
Noris
Toscana Inn
Outdoor pool, pool umbrellas, pool loungers
Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG
3.5 star property
12.6 km from Santa Clara
8.6 out of 10, Excellent, (443)
"The staff was so cordial and nice "
United States
Sonny
The price is 2.549.924 ₫
3.239.114 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Panama Canal by IHG
Executive Duplex | Terrace/patio
Oasis Hotel

Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 11.5 km from Santa Clara
8.4 out of 10, Very good, (106)
"This place is fine. However, on Monday nite there was dance music playing most of nite from all directions. Impossible to sleep well "
United States
roberta
The price is 1.953.889 ₫
2.149.409 ₫ total
includes taxes & fees
19 Jan - 20 Jan 2026
Oasis Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Clara

Find the best Santa Clara areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Clara Hotel Reviews

Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"The hotel was stunning and christmas festive. It smelled great. The room was beautiful, the hospitality was great. I was suprised with a birthday treat to my door and a card which was super sweet and an excellent touch. Everything was clean. Room service made my bed and changed my towels everyday. Staff was kind and helpful even with the language barrier( I practiced communicating in Spanish). Check-in and check- out was easy and quick. My birthday accommodations were amazing. I was very thankful and comfortable. "
Re'neisha 4-night trip
Posted 2 weeks ago
Hyatt Regency Panama City

Frequently asked questions

What is Santa Clara like?
Travellers will be sure to find plenty to entertain them in Panama City's Santa Clara neighbourhood.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals in Santa Clara.
What are the top things to see and do in Santa Clara?
A few places to visit in the area around Santa Clara include Estadio Rommel Fernandez, Plaza de Francia and Atrio Mall. While you're out sightseeing, Monte Oscuro and Los Pueblos Commercial Center are a couple of additional sights to visit in Panama City.

Explore a world of travel with Expedia