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14 Dec - 15 Dec
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Our top choices for Santa Clara hotels

Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.0 star property
9.7 km from Santa Clara
9.0 out of 10, Wonderful, (37)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is 3.156.840 ₫
3.472.524 ₫ total
includes taxes & fees
16 Dec - 17 Dec
ORHO HOTEL BOUTIQUE PANAMA Airport
Front of property
La Concordia Boutique Hotel

La Concordia Boutique Hotel

La Concordia Boutique Hotel
4.0 star property
San Felipe, 11.7 km from Santa Clara
9.6 out of 10, Exceptional, (194)
"Beautiful room Good location"
United States
Karla
The price is 6.579.350 ₫
7.237.285 ₫ total
includes taxes & fees
16 Dec - 17 Dec
La Concordia Boutique Hotel
47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 11.5 km from Santa Clara
9.0 out of 10, Wonderful, (1004)
"Excellent hotel , good breakfast, great location, would highly recommend "
United States
Glen
The price is 5.255.079 ₫
5.780.587 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Central Hotel Panama Casco Viejo
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 2.8 km from Santa Clara
9.6 out of 10, Exceptional, (638)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is 6.096.647 ₫
6.706.312 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Breakfast and dinner served, international cuisine
Amarla Boutique Hotel Casco Viejo

Amarla Boutique Hotel Casco Viejo

Amarla Boutique Hotel Casco Viejo
3.0 star property
San Felipe, 11.4 km from Santa Clara
9.6 out of 10, Exceptional, (106)
"Great little hotel in Casco Viejo. Rooms are small, but comfortable. Reception is a bit odd, but service was nice. "
United States
Frederick
Amarla Boutique Hotel Casco Viejo
Balcony
Taboga Palace Spa Hotel

Taboga Palace Spa Hotel

Taboga Palace Spa Hotel
3.5 star property
28.1 km from Santa Clara
9.0 out of 10, Wonderful, (38)
"One of the nicest buildings on the Island and right to the Ferry. David the owner was super nice and helpful. Had beautiful views from the room and a private balcony. Overall great place to stay on a visit to the Island."
United States
Malcolm
The price is 3.419.910 ₫
3.761.901 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Taboga Palace Spa Hotel
Outdoor pool
MARINN PLACE Financial District

MARINN PLACE Financial District

MARINN PLACE Financial District
3.5 star property
Campo Alegre, 8.3 km from Santa Clara
9.2 out of 10, Wonderful, (299)
"Second stay, very nice"
Canada
Xiaozhi
The price is 6.629.364 ₫
7.292.300 ₫ total
includes taxes & fees
16 Dec - 17 Dec
MARINN PLACE Financial District
4 outdoor pools, free pool cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
Punta Pacifica, 7.8 km from Santa Clara
9.0 out of 10, Wonderful, (1007)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is 6.605.688 ₫
7.266.257 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Panama
Meeting facility
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 7.5 km from Santa Clara
8.8 out of 10, Excellent, (1003)
"Amazing amazing service"
United States
KFIR
The price is 4.182.813 ₫
4.601.094 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Living area
Magnolia Inn

Magnolia Inn

Magnolia Inn
2.0 star property
San Felipe, 11.6 km from Santa Clara
8.8 out of 10, Excellent, (413)
"Excelent location , friendly staff and cute hotel"
Canada
Renata
The price is 2.004.594 ₫
2.205.053 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Magnolia Inn
Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 8 km from Santa Clara
9.0 out of 10, Wonderful, (4668)
"Awesome great place to stay "
United States
Herbert
The price is 3.371.118 ₫
3.708.230 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hotel Riu Plaza Panama
Executive Duplex | Terrace/patio
Oasis Hotel

Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 11.5 km from Santa Clara
8.6 out of 10, Excellent, (103)
"Very friendly staff and good location"
United States
Edward
The price is 1.562.636 ₫
1.718.900 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Oasis Hotel
Front of property
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel
3.5 star property
Amador, 14.8 km from Santa Clara
8.2 out of 10, Very good, (185)
"Great location "
United States
itzel
The price is 1.620.511 ₫
1.782.562 ₫ total
includes taxes & fees
16 Dec - 17 Dec
MARINN Tropical Vibes Hotel
Interior
Villa Caprichosa

Villa Caprichosa

Villa Caprichosa
3.0 star property
28.6 km from Santa Clara
9.8 out of 10, Exceptional, (42)
"We loved the place and the attention given by the staff."
United States
Juan Carlos
The price is 6.576.750 ₫
7.234.425 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Villa Caprichosa
Terrace/patio
Exe Oriental Panama

Exe Oriental Panama

Exe Oriental Panama
4.0 star property
Campo Alegre, 8.1 km from Santa Clara
8.0 out of 10, Very good, (1000)
"Comfortable stay"
United States
Jostin
The price is 2.104.560 ₫
2.315.016 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Exe Oriental Panama
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
19.1 km from Santa Clara
8.0 out of 10, Very good, (1002)
"Our stay was very nice, the service the hotel provides is wonderful, I highly recommend it"
United States
Mayra Alexandra Montes
The price is 5.235.093 ₫
5.758.602 ₫ total
includes taxes & fees
16 Dec - 17 Dec
The Westin Playa Bonita Panama
Apartment (3G) | Balcony
La Cuadra by Wynwood House

La Cuadra by Wynwood House

La Cuadra by Wynwood House
3.5 star property
El Chorrillo, 11.8 km from Santa Clara
9.2 out of 10, Wonderful, (44)
"Love the property. You are right at the start of the nice part of casco viejo but the blocks around it are rough and ugly. The police are very prominent so it's safe but be on alert"
United States
Carlos
The price is 3.446.217 ₫
4.448.514 ₫ total
includes taxes & fees
17 Dec - 18 Dec
La Cuadra by Wynwood House
Balcony
Hotel Casa Panamá

Hotel Casa Panamá

Hotel Casa Panamá
4.0 star property
San Felipe, 11.5 km from Santa Clara
7.4 out of 10, Good, (590)
"Location is absolutely amazing"
United States
John
The price is 1.911.502 ₫
2.102.652 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Casa Panamá
Outdoor pool, pool umbrellas, pool loungers
InterContinental Miramar Panama by IHG

InterContinental Miramar Panama by IHG

InterContinental Miramar Panama by IHG
4.0 star property
Bella Vista, 9 km from Santa Clara
8.6 out of 10, Excellent, (533)
"Room was excellent… meals that accompanied room were good and the staff was friendly and helpful"
United States
Hanley Clifton
The price is 4.472.190 ₫
4.919.409 ₫ total
includes taxes & fees
19 Dec - 20 Dec
InterContinental Miramar Panama by IHG
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 11.4 km from Santa Clara
9.8 out of 10, Exceptional, (557)
"Great hotel and location "
United Kingdom
Russell
The price is 9.944.046 ₫
10.938.451 ₫ total
includes taxes & fees
13 Jan - 14 Jan 2026
Sofitel Legend Casco Viejo, Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Clara

Find the best Santa Clara areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Clara Hotel Reviews

Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"The hotel was stunning and christmas festive. It smelled great. The room was beautiful, the hospitality was great. I was suprised with a birthday treat to my door and a card which was super sweet and an excellent touch. Everything was clean. Room service made my bed and changed my towels everyday. Staff was kind and helpful even with the language barrier( I practiced communicating in Spanish). Check-in and check- out was easy and quick. My birthday accommodations were amazing. I was very thankful and comfortable. "
Re'neisha 4-night trip
Posted 9 days ago
Hyatt Regency Panama City

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Frequently asked questions

What is Santa Clara like?
Travellers will be sure to find plenty to entertain them in Panama City's Santa Clara neighbourhood.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals in Santa Clara.
What are the top things to see and do in Santa Clara?
A few places to visit in the area around Santa Clara include Estadio Rommel Fernandez, Plaza de Francia and Atrio Mall. While you're out sightseeing, Monte Oscuro and Los Pueblos Commercial Center are a couple of additional sights to visit in Panama City.