Search Luxury Hotels in Santa Cruz

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Check availability on Santa Cruz Luxury Hotels

Tonight
5 Dec - 6 Dec
Tomorrow
6 Dec - 7 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Santa Cruz Luxury Hotels

Indoor pool, outdoor pool, pool umbrellas
Camino Real Hotel

Camino Real Hotel

4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
The price is 4.746.780 ₫
4.746.780 ₫ total
25 Dec - 26 Dec
Camino Real Hotel
Outdoor pool, pool umbrellas, pool loungers
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (210)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is 2.932.455 ₫
2.932.455 ₫ total
12 Dec - 13 Dec
Marriott Santa Cruz de la Sierra Hotel
Massages
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"Beautiful hotel"
Australia
Joanna
The price is 3.902.908 ₫
3.902.908 ₫ total
1 Jan - 2 Jan 2026
Swissôtel Santa Cruz De La Sierra
Exterior
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (103)
"Great location and very clean hotel. Will stay again soon."
United States
William
The price is 2.637.100 ₫
2.637.100 ₫ total
20 Dec - 21 Dec
Novotel Santa Cruz De La Sierra
Lounge
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (253)
"Nice hotel "
United States
Narciso Lorenzo
The price is 1.687.744 ₫
1.687.744 ₫ total
12 Dec - 13 Dec
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Outdoor pool, open 9:00 AM to 10:00 PM, free pool cabanas
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
The price is 2.012.107 ₫
2.012.107 ₫ total
6 Dec - 7 Dec
TRYP by Wyndham Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

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Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
Fly into Santa Cruz (VVI-Viru Viru Intl.) Airport and then pamper yourself by staying at one of 7 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Blacutt Square, so you might want to take in the local sights during your visit.
How many luxury hotels are there in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 7 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Blacutt Square and Ramon Tahuichi Aguilera Stadium. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To venture out into the surrounding area, hop aboard a train at Santa Cruz de la Sierra Station.