Santa Lucia Holidays

Book a Hotel + Flight or Car together to unlock savings

Photo by William Keller

Where to stay in Santa Lucia

Find the best Santa Lucia areas and neighborhoods for the activities you enjoy most. Learn more about Santa Lucia
Ortigia

Ortigia

4 out of top 10 points of interest in this area
4.5/5(49 area reviews)

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

Find hotels in Ortigia

Top hotels in Santa Lucia

Grande Albergo Alfeo

Grande Albergo Alfeo

4 out of 5
Via Nino Bixio 5 Syracuse SR
The price is 3.558.333 ₫ per night from 21 Apr to 22 Apr
3.558.333 ₫
4.056.326 ₫ total
21 Apr - 22 Apr
includes taxes & fees
8.6/10 Excellent! (660 reviews)
Good front desk staff, welcoming breakfast staff, clean room and good area for walking to attractions.

Reviewed on 2 Dec 2025

Grande Albergo Alfeo
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5 out of 5
Viale Montedoro 76 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is 4.803.805 ₫ per night from 18 Apr to 19 Apr
4.803.805 ₫
5.595.019 ₫ total
18 Apr - 19 Apr
includes taxes & fees
Caportigia Boutique Hotel
Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia

3 out of 5
Corso Umberto, 112 Syracuse SR
Fully refundableReserve now, pay when you stay
The price is 2.008.012 ₫ per night from 21 Apr to 22 Apr
2.008.012 ₫
2.289.275 ₫ total
21 Apr - 22 Apr
includes taxes & fees
8.6/10 Excellent! (377 reviews)
Lovely simple breakfast. Clean, good location. Nice staff. Just what we wanted.

Reviewed on 11 Apr 2026

Piccolo Hotel Casa Mia
See all 3,729 properties in Santa Lucia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Lucia holiday package cost?
Our Santa Lucia packages, which start from just , are the perfect way to save loads of cash. All you have to do is choose your preferred flights, hotels and rental cars to create your ideal escape.
How do I get a cheap travel package to Santa Lucia?
Combine your hotels and flights, throw in extras such as a rental car or activities, and save with a Santa Lucia holiday package. You won't just score big discounts on your escape — you'll have lots of choice at your fingertips too. When you book with Expedia, you can choose from more than 550 airlines and 1null000null000 hotels all over the world. Your affordable holiday begins right here, right now!
Where should I stay in Santa Lucia?
Take the hassle out of sightseeing by staying in a hotel right around the corner from Santa Lucia's iconic attractions. Cathedral of Syracuse and Temple of Apollo are two visitor favourites.
What are the top hotels in Santa Lucia?
If this will be your first time in Santa Lucia, book a room at Hotel Cavalieri or Paolanna Luxury Rooms. Both hotels offer friendly service and are popular options with many travellers.
How far in advance should I book my Santa Lucia holiday?
Smart travellers will likely want to reserve their seats early. You can normally compare international fares on Expedia up to 12 months before your flight. If you're purchasing tickets last minute, don't stress. Budget prices occasionally appear in the last weeks prior to departure.
What does an Expedia Santa Lucia travel package include?
Packages include hotels, flights and rental cars, but you can mix and match them to create your ideal Santa Lucia holiday. You can also add on some activities and experiences once you've made your booking. You're in charge! When you bundle your bookings with Expedia, you'll score discounts you won't find anywhere else.
What should I know before booking a Santa Lucia travel package?
You'll land impressive savings when you bundle your hotels, flights and rental cars into a package. Plus, booking everything in one place will make your trip planning easier. So why waste money or time? Whether you're putting together a ritzy romantic getaway or a budget family adventure, browse our package deals today.
Can I choose my airline with a Santa Lucia Expedia holiday package?
You can, and with more than 550 airlines to pick from globally, you have plenty of choice. Search the available options and find out which airline best fits your needs and budget.
If I'm not able to travel, can I cancel my Santa Lucia holiday package?
Yes, you can. We realise life doesn't always go to plan, so we're here to help if you have to make changes to your Santa Lucia holiday package. It may be possible to cancel or amend your itinerary at no cost if you've booked in the last 24 hours. Your airline, hotel or car rental company may charge you a fee if your booking was made more than 24 hours ago. Visit our Customer Service Portal for further information. Also, check your itinerary for the nitty-gritty on change fees.

Popular places to visit

Syracuse Forum Ruins

You can learn about the history of Syracuse with a trip to Syracuse Forum Ruins. Wander through the beautiful beaches and seaside in this culturally rich area.

Syracuse Forum Ruins

Santa Lucia al Sepolcro Basilica

Find out about the history of Syracuse when you spend time at Santa Lucia al Sepolcro Basilica. Wander the seaside in this culturally rich area.

Santa Lucia al Sepolcro Basilica

Piazza Santa Lucia

You can find out about the history of Syracuse with a trip to Piazza Santa Lucia. Wander through the beautiful beaches and seaside in this culturally rich area.

Piazza Santa Lucia