Find hotels in Santee, SC from 1.654.825 ₫

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
5 Jun - 7 Jun
Next weekend
12 Jun - 14 Jun

Filter by

Guest rating
Guest rating
Star rating
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Santee attractions

Santee State Park

4.0/5 (219 reviews)
Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.
See properties

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campsites.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

10/10 Excellent
"The property was very clean and the people were all very polite and friendly the breakfast was delicious"
Carolyn 1-night trip
Posted less than an hour ago
Hampton Inn Santee-I-95

More cheap stays in Santee

Peach Tree Inn

Peach Tree Inn

111 Conners Dr St. George SC
The price is 1.565.887 ₫ per night from 2 Jun to 3 Jun
1.565.887 ₫
1.691.400 ₫ total
2 Jun - 3 Jun
includes taxes & fees
7.2/10 Good! (217 reviews)

Hotels in Santee with star rating

Frequently asked questions

What's the seasonal weather like in Santee?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.