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11 Dec - 12 Dec
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12 Dec - 13 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Santo Domingo hotels

Indoor pool, open 6 AM to 8 PM, pool loungers
Barceló México Reforma

Barceló México Reforma

Barceló México Reforma
4.5 star property
11.9 km from Santo Domingo
9.4 out of 10, Exceptional, (5057)
"Overall its a great hotel"
United States
Ariel
The price is 2.941.141 ₫
3.514.664 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Barceló México Reforma
Lobby
Hotel Casa Blanca

Hotel Casa Blanca

Hotel Casa Blanca
3.5 star property
11.9 km from Santo Domingo
9.0 out of 10, Wonderful, (1187)
"Location and spacious room "
United States
Anthony
The price is 2.415.865 ₫
2.886.958 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Casa Blanca
Exterior
Galeria Plaza Reforma

Galeria Plaza Reforma

Galeria Plaza Reforma
4.0 star property
Zona Rosa, 10.7 km from Santo Domingo
9.4 out of 10, Exceptional, (3166)
"Great place, centrally located, very walkable."
United States
Jeffrey
The price is 3.257.132 ₫
3.892.273 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Galeria Plaza Reforma
Premium Loft | View from room
Marquis Reforma Hotel Spa

Marquis Reforma Hotel Spa

Marquis Reforma Hotel Spa
4.5 star property
Colonia Cuauhtémoc, 10.7 km from Santo Domingo
9.4 out of 10, Exceptional, (1084)
"Everything perfect during the stay "
United States
German
The price is 4.453.761 ₫
5.322.245 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Marquis Reforma Hotel Spa
Rooftop terrace
Casa Decu

Casa Decu

Casa Decu
4.0 star property
Hipódromo, 8.9 km from Santo Domingo
9.4 out of 10, Exceptional, (813)
"Clean rooms, the staff was helpful and courteous.The bathrooms are a bit tight - but for the price its hard to complain. "
United States
Walid
Casa Decu
Breakfast, lunch, dinner served; Mexican cuisine
Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City
4.0 star property
Historic Center, 12.2 km from Santo Domingo
9.8 out of 10, Exceptional, (2640)
"Always a great stay. Great staff, food and comfortable room."
Canada
John
The price is 4.379.466 ₫
5.233.462 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Zocalo Central & Rooftop Mexico City
Indoor pool, outdoor pool
Sevilla Palace Hotel

Sevilla Palace Hotel

Sevilla Palace Hotel
4.0 star property
11.6 km from Santo Domingo
9.0 out of 10, Wonderful, (2958)
"nice hotel friendly stafff good breakfast amd the pool is very convenient for my vacation "
United States
Juan
The price is 2.448.856 ₫
2.926.383 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sevilla Palace Hotel
Suite, Terrace | Premium bedding, down duvets, pillow-top beds, in-room safe
AR 218 Hotel by ULIV

AR 218 Hotel by ULIV

AR 218 Hotel by ULIV
4.0 star property
Hipódromo, 8.8 km from Santo Domingo
9.4 out of 10, Exceptional, (1000)
"Clean room, friendly staff, nice environment and amazing location"
United States
Yue
AR 218 Hotel by ULIV
Presidential Suite, 1 King Bed | Bathroom | Shower, hair dryer, towels
Hilton Mexico City Reforma

Hilton Mexico City Reforma

Hilton Mexico City Reforma
4.5 star property
Reforma, 12 km from Santo Domingo
9.4 out of 10, Exceptional, (1053)
"great place . friendly staff and everything was to perfection."
United States
Adriana
The price is 4.659.918 ₫
5.568.602 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Hilton Mexico City Reforma
Exterior
Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico
3.0 star property
Historic Center, 11.7 km from Santo Domingo
9.0 out of 10, Wonderful, (1079)
"Great location and customer services "
Canada
Hernan
The price is 1.979.941 ₫
2.365.924 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Mexico City - Centro Historico
Bar (on property)
Camino Real Polanco Mexico

Camino Real Polanco Mexico

Camino Real Polanco Mexico
4.5 star property
11.1 km from Santo Domingo
9.2 out of 10, Wonderful, (3126)
"Perfect place to stay "
United States
Howard
The price is 2.550.229 ₫
3.047.524 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Camino Real Polanco Mexico
Breakfast, lunch, brunch served; Mexican cuisine
Hotel Bellas Artes

Hotel Bellas Artes

Hotel Bellas Artes
4.0 star property
Historic Center, 12.1 km from Santo Domingo
9.8 out of 10, Exceptional, (547)
"Very nice staff, the location is perfect, amenities definitely will consider to stay in the future "
United States
Nelson
The price is 2.156.898 ₫
2.577.493 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Bellas Artes
Lobby
Geneve Ciudad de México

Geneve Ciudad de México

Geneve Ciudad de México
4.0 star property
Zona Rosa, 10.7 km from Santo Domingo
9.0 out of 10, Wonderful, (1722)
"Great location, customer service and the hotel was nice and clean "
United States
Victor
The price is 2.455.142 ₫
2.933.895 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Geneve Ciudad de México
Front of property – evening/night
Historico Central Hotel

Historico Central Hotel

Historico Central Hotel
4.0 star property
Historic Center, 12 km from Santo Domingo
9.8 out of 10, Exceptional, (2399)
"Location was great and hotel was clean and comfortable "
United States
Daniela
The price is 3.800.152 ₫
4.541.181 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Historico Central Hotel
Courtyard
Hotel Casa González

Hotel Casa González

Hotel Casa González
3.0 star property
Colonia Cuauhtémoc, 11.3 km from Santo Domingo
9.0 out of 10, Wonderful, (390)
"Excellent place, very comfortable "
Mexico
A
The price is 1.885.718 ₫
2.253.430 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Casa González
Front of property
Emporio Reforma

Emporio Reforma

Emporio Reforma
3.5 star property
Juárez, 11.5 km from Santo Domingo
8.8 out of 10, Excellent, (1003)
"excellent staff & service. Could not ask for a better location."
United States
Babar
The price is 2.244.112 ₫
2.681.714 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Emporio Reforma
Club Suite, 1 Bedroom | Premium bedding, minibar, in-room safe, desk
Sheraton Maria Isabel Mexico City Reforma

Sheraton Maria Isabel Mexico City Reforma

Sheraton Maria Isabel Mexico City Reforma
4.0 star property
Colonia Cuauhtémoc, 11 km from Santo Domingo
9.2 out of 10, Wonderful, (2134)
"Very nice hotel. I really enjoyed my stay there."
United States
Rina Vazquez
The price is 3.496.491 ₫
4.178.307 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton Maria Isabel Mexico City Reforma
Premier Double Room | Select Comfort beds, in-room safe, individually decorated, desk
KALI Centro Mexico City

KALI Centro Mexico City

KALI Centro Mexico City
3.0 star property
Downtown Mexico City, 11.2 km from Santo Domingo
9.4 out of 10, Exceptional, (349)
"Staff was amazing and friendly. Hotel was quaint and very clean snd comfortable!"
United States
Anne
The price is 2.043.859 ₫
2.442.412 ₫ total
includes taxes & fees
14 Dec - 15 Dec
KALI Centro Mexico City
Deluxe Double Room | Premium bedding, in-room safe, desk, iron/ironing board
Reforma Capital Inn

Reforma Capital Inn

Reforma Capital Inn
2.0 star property
Juárez, 10.8 km from Santo Domingo
8.6 out of 10, Excellent, (247)
"Todo excelente "
Mexico
Maritza
Reforma Capital Inn
Lobby
Fiesta Inn Periferico Sur

Fiesta Inn Periferico Sur

Fiesta Inn Periferico Sur
3.5 star property
Coyoacan, 2.9 km from Santo Domingo
8.8 out of 10, Excellent, (1093)
"Nice hotel"
Canada
Yan
The price is 2.138.871 ₫
2.555.839 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Fiesta Inn Periferico Sur
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santo Domingo

Find the best Santo Domingo areas for the activities you enjoy most.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

Polanco which includes heritage architecture, a church or cathedral and a park

Polanco

If you're spending time in Polanco, you might enjoy attractions like Paseo de la Reforma and Avenida Presidente Masaryk. You might also enjoy the neighbourhood's ample dining options before hopping on the metro at Polanco Station to see more of the city.

La Condesa featuring café scenes

La Condesa

Spend some time visiting places like Blackberry Auditorium while getting to know La Condesa, and be sure to check out the abundant dining options. You can hop aboard the metro at Patriotism Station or Chilpancingo Station to see more of the area.

Metropolitan Cathedral which includes a church or cathedral, heritage elements and heritage architecture

Historic Center

Consider a visit to Palacio de Bellas Artes and take some time to enjoy the interesting museums during your time in Historic Center. If you want to see more of the city, jump on the metro at Allende Station or Bellas Artes Station.

Reforma which includes a city, night scenes and central business district

Reforma

Consider a visit to Paseo de la Reforma and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

Top Santo Domingo Hotel Reviews

ULIV Mexico City

ULIV Mexico City

10/10 Excellent
"Excellent location, clean and comfortable room"
Esther 5-night trip
Posted 3 days ago
ULIV Mexico City

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Frequently asked questions

What is Santo Domingo like?
Travellers to Mexico City's Santo Domingo neighbourhood will be sure to enjoy a stay here.
How many hotels will I find in the Santo Domingo area?
Book one of Expedia's 5 hotels and other accommodation options in Santo Domingo and start exploring everything Mexico City has to offer.
If I need to cancel my hotel reservation in Santo Domingo, will I receive a refund?
Yes, most room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best deals available in Santo Domingo.
What are the top things to see and do in Santo Domingo?
Parroquia de San Juan Bautista, Casa del Teatro and Museo Diego Rivera Anahuacalli are just a few of the places to visit in and around Santo Domingo. While you're out sightseeing, Museo de la Ciudad and Hidalgo Plaza are a couple of additional sights to visit in Mexico City.