Search Hotels in Serra Mesa, San Diego

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

Tonight
2 Jul - 3 Jul
Tomorrow
3 Jul - 4 Jul
This weekend
4 Jul - 6 Jul
Next weekend
11 Jul - 13 Jul

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Serra Mesa, San Diego

Humphreys Half Moon Inn
Outdoor pool

Humphreys Half Moon Inn

3.5 star property
9.2 out of 10, Wonderful, (2378)
"Great pool and pool bar eating options."
The price is 4.680.062 ₫
5.902.209 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Humphreys Half Moon Inn
Town and Country San Diego
2 outdoor pools, a heated pool, pool cabanas (surcharge), pool loungers

Town and Country San Diego

4.0 star property
8.6 out of 10, Excellent, (1204)
"Great stay excellent service great food"
The price is 5.879.475 ₫
7.659.943 ₫ total
includes taxes & fees
2 Aug - 3 Aug
Town and Country San Diego
Best Western Plus Island Palms Hotel & Marina
Reception

Best Western Plus Island Palms Hotel & Marina

3.0 star property
8.8 out of 10, Excellent, (1557)
"Great location! Beautiful pools!"
The price is 4.325.413 ₫
4.971.846 ₫ total
includes taxes & fees
20 Jul - 21 Jul
Best Western Plus Island Palms Hotel & Marina
Lafayette Hotel & Club
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)

Lafayette Hotel & Club

4.0 star property
9.2 out of 10, Wonderful, (933)
"The rooms were very well equipped and comfortable, the pool and pool area was lovely. "
The price is 6.375.964 ₫
7.316.419 ₫ total
includes taxes & fees
7 Jul - 8 Jul
Lafayette Hotel & Club
The Shoal La Jolla Beach
Front of property

The Shoal La Jolla Beach

2.5 star property
8.6 out of 10, Excellent, (1001)
"Stayed here 4 nights, and it was such a cute spot! So close to the beach, and neutral to all the spots like La Jolla cove, Pacific beach, mission beach! Would stay again!"
The price is 5.785.438 ₫
6.534.362 ₫ total
includes taxes & fees
13 Jul - 14 Jul
The Shoal La Jolla Beach
Country Inn & Suites by Radisson, San Diego North, CA
Meeting facility

Country Inn & Suites by Radisson, San Diego North, CA

3.0 star property
9.0 out of 10, Wonderful, (1212)
"Clean room, great breakfast, and good location!"
The price is 4.840.768 ₫
5.564.335 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Country Inn & Suites by Radisson, San Diego North, CA
La Jolla Shores Hotel
Balcony view

La Jolla Shores Hotel

3.0 star property
8.8 out of 10, Excellent, (1337)
"It’s a great hotel to stay"
The price is 12.194.031 ₫
15.221.830 ₫ total
includes taxes & fees
6 Jul - 7 Jul
La Jolla Shores Hotel
Staypineapple, Hotel Z, Gaslamp San Diego
Premium bedding, pillow-top beds, desk, blackout curtains

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Excellent for dogs!"
The price is 3.975.832 ₫
5.364.964 ₫ total
includes taxes & fees
21 Jul - 22 Jul
Staypineapple, Hotel Z, Gaslamp San Diego
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very good, (1000)
"Stayed here while visiting friends, best in the area and very comfortable. "
The price is 3.323.863 ₫
3.656.249 ₫ total
includes taxes & fees
9 Jul - 10 Jul
Best Western Plus La Mesa San Diego
The Sofia Hotel
Exterior

The Sofia Hotel

3.5 star property
8.4 out of 10, Very good, (1475)
"Excellent stay in a great location"
The Sofia Hotel
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1002)
"Great place to stay! It’s so beautiful and very relaxing! "
The price is 6.767.929 ₫
8.722.267 ₫ total
includes taxes & fees
13 Jul - 14 Jul
Loews Coronado Bay Resort
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3109)
"Great place to stay, amazing beds!"
The price is 5.147.922 ₫
5.672.753 ₫ total
includes taxes & fees
8 Jul - 9 Jul
Best Western Plus Marina Gateway Hotel
San Diego Mission Bay Resort
Outdoor pool, open 9:00 AM to 9:00 PM, pool cabanas (surcharge)

San Diego Mission Bay Resort

4.0 star property
8.4 out of 10, Very good, (1256)
"Amazing stay here! The staff is all so friendly and helpful!! Will stay here again every time we visit!!!"
The price is 7.813.169 ₫
10.158.687 ₫ total
includes taxes & fees
6 Jul - 7 Jul
San Diego Mission Bay Resort
Hyatt Regency Mission Bay Spa and Marina
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Hyatt Regency Mission Bay Spa and Marina

4.0 star property
8.4 out of 10, Very good, (1476)
"The property was very nice and had great amenities for the kids. "
The price is 5.980.793 ₫
8.163.391 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Hyatt Regency Mission Bay Spa and Marina
The Rambler Motel
View from room

The Rambler Motel

3.0 star property
9.0 out of 10, Wonderful, (1842)
"Great stay! "
The price is 3.504.128 ₫
4.054.101 ₫ total
includes taxes & fees
7 Jul - 8 Jul
The Rambler Motel
Inn By The Sea La Jolla
View from property

Inn By The Sea La Jolla

3.5 star property
9.2 out of 10, Wonderful, (1591)
"Had a great stay. "
The price is 5.486.203 ₫
6.306.194 ₫ total
includes taxes & fees
20 Jul - 21 Jul
Inn By The Sea La Jolla
Westgate Hotel
Outdoor pool, pool loungers

Westgate Hotel

4.5 star property
8.8 out of 10, Excellent, (1001)
"Quiet place in a great location. Staff is top-notch."
The price is 4.420.059 ₫
6.008.326 ₫ total
includes taxes & fees
8 Jul - 9 Jul
Westgate Hotel
Sycuan Casino Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1358)
"I enjoyed the location and the pool area."
Sycuan Casino Resort
Grande Colonial Hotel
Meeting facility

Grande Colonial Hotel

4.0 star property
9.4 out of 10, Exceptional, (1001)
"This property was very close to the beach, shops, and restaurants. "
The price is 8.074.479 ₫
10.603.960 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Grande Colonial Hotel
Berkshire Motor Hotel
Suite | Private kitchenette

Berkshire Motor Hotel

2.5 star property
8.4 out of 10, Very good, (937)
"Great location within walking distance from the places we wanted to visit."
The price is 2.702.207 ₫
3.046.614 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Berkshire Motor Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Seaport Village and Petco Park are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Belmont Park featuring a park and rides
Mission Beach map

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Gaslamp Quarter featuring a bar, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach map

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Ocean Beach.

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 36 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.