Search Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,815 reviews)
"Great resort "
United States
Ines
The price is 3.926.448 ₫
4.326.735 ₫ total
includes taxes & fees
17 May - 18 May
Best Western Plus Marina Gateway Hotel

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
9.0 out of 10, Wonderful, (1,282 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
United States
Nicole
The price is 2.690.012 ₫
3.059.888 ₫ total
includes taxes & fees
28 May - 29 May
Best Western Americana Inn

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
10.8 km from Serra Mesa
9.2 out of 10, Wonderful, (2,124 reviews)
"Excellent stay!"
United States
Joyce
The price is 5.665.680 ₫
7.817.914 ₫ total
includes taxes & fees
25 May - 26 May
Marriott Marquis San Diego Marina

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,919 reviews)
"It is a perfect hotel if breakfast is included in the stay."
United States
Tugba
The price is 2.598.307 ₫
3.174.362 ₫ total
includes taxes & fees
26 May - 27 May
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
5.3 km from Serra Mesa
9.4 out of 10, Exceptional, (1,650 reviews)
"This is a must stay place in San Diego"
United States
Kristi
The price is 6.561.648 ₫
7.542.286 ₫ total
includes taxes & fees
18 May - 19 May
Lafayette Hotel & Club

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,528 reviews)
"Excellent food, friendly staff, easy check-in, and beautiful setting. "
United States
Emily
The price is 4.453.488 ₫
6.452.024 ₫ total
includes taxes & fees
24 May - 25 May
Sheraton San Diego Resort

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,714 reviews)
"Staff are very helpful and nearby places to eat are accessible, also near to the airport!"
United States
Mercyditha De
The price is 4.719.643 ₫
5.424.994 ₫ total
includes taxes & fees
31 May - 1 Jun
Hampton Inn & Suites San Diego Airport Liberty Station

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 7.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,439 reviews)
"Perfect place for a family trip "
United States
Krystal
The price is 5.244.048 ₫
7.421.266 ₫ total
includes taxes & fees
17 May - 18 May
San Diego Mission Bay Resort

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
26 km from Serra Mesa
9.8 out of 10, Exceptional, (1,097 reviews)
"The Ayres hotels are always mine and my families favorite hotel! "
United States
Paola
The price is 4.956.811 ₫
5.462.242 ₫ total
includes taxes & fees
31 May - 1 Jun
Ayres Hotel San Diego South - Chula Vista

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,154 reviews)
"Very nice place to stay"
United States
Lingzhi
The price is 3.203.086 ₫
3.523.395 ₫ total
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego South - Chula Vista by IHG

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1,004 reviews)
"Love it great place"
United States
Derek
The price is 5.017.421 ₫
5.767.274 ₫ total
includes taxes & fees
27 May - 28 May
TownePlace Suites by Marriott San Diego Airport/Liberty Station

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
8.0 out of 10, Very good, (1,325 reviews)
"Wonderful, kind staff and good breakfast"
United States
Kimberly
The price is 2.634.146 ₫
3.027.818 ₫ total
includes taxes & fees
17 May - 18 May
Best Western San Diego/Miramar Hotel

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,002 reviews)
"Well maintained property, staff were professional and very nice"
United States
Cherie
The price is 2.228.062 ₫
2.451.000 ₫ total
includes taxes & fees
17 May - 18 May
Ramada by Wyndham San Diego Poway Miramar

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
18.6 km from Serra Mesa
8.2 out of 10, Very good, (1,492 reviews)
"We really enjoyed our stay here! Breakfast in the morning was great & staff was always friendly & helpful!"
United States
Megan
The price is 2.822.299 ₫
3.110.174 ₫ total
includes taxes & fees
25 May - 26 May
Comfort Inn Chula Vista San Diego South

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,768 reviews)
"Breakfast , stafff and building was very well kept "
United States
Tykayla
The price is 5.315.725 ₫
7.119.368 ₫ total
includes taxes & fees
27 May - 28 May
Embassy Suites by Hilton San Diego Bay Downtown

HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa
3.0 star property
11.8 km from Serra Mesa
9.2 out of 10, Wonderful, (1,001 reviews)
"Breakfast was delicious and staff friendly Room was clean and spacious."
United States
Rosa
The price is 3.793.680 ₫
4.360.646 ₫ total
includes taxes & fees
27 May - 28 May
HYATT house San Diego/Sorrento Mesa

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
3.0 star property
8.2 km from Serra Mesa
9.2 out of 10, Wonderful, (943 reviews)
"The hotel was super clean and close to a lot of good food places!"
United States
Buna
The price is 3.854.771 ₫
4.431.089 ₫ total
includes taxes & fees
28 May - 29 May
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Humphreys Half Moon Inn

Humphreys Half Moon Inn
3.5 star property
12.3 km from Serra Mesa
9.2 out of 10, Wonderful, (2,972 reviews)
"Awesome stay "
United States
VINCENT
The price is 5.507.568 ₫
6.857.844 ₫ total
includes taxes & fees
20 May - 21 May
Humphreys Half Moon Inn

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,617 reviews)
"Great stay"
United States
Helda
The price is 2.799.900 ₫
3.079.890 ₫ total
includes taxes & fees
27 May - 28 May
La Quinta Inn by Wyndham San Diego Chula Vista

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,056 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is 4.162.510 ₫
4.784.779 ₫ total
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.