The Best Hotels in Serra Mesa, San Diego - 2026 Updated Prices

A residential area with houses, roads, and a hilly landscape.

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Our top choices for Serra Mesa hotels

A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

1. Hampton Inn San Diego-Kearny Mesa

3.5 km from Serra Mesa

Sonya

3.422.776 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.

2. Legacy Resort Hotel & Spa

5.8 km from Serra Mesa

christopher

5.145.983 ₫ total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.

3. DoubleTree by Hilton Hotel San Diego - Mission Valley

4.2 km from Serra Mesa

Paul

4.385.610 ₫ total

includes taxes & fees

22 Oct - 23 Oct

A modern building with multiple windows, outdoor seating, and a chessboard.

4. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

8.2 km from Serra Mesa

Xuan

4.875.623 ₫ total

includes taxes & fees

13 Oct - 14 Oct

A poolside view with a lounge chair, a towel, a tray with a drink and a coconut, and a pool with palm trees in the background.

5. San Diego Mission Bay Resort

Mission Bay, 7.2 km from Serra Mesa

brittany

7.918.033 ₫ total

includes taxes & fees

28 Oct - 29 Oct

A modern dining area with wooden tables and chairs, a central bar area, and a view of the city through large windows.

6. La Quinta Inn & Suites by Wyndham San Diego Mission Bay

North Pacific Beach, 7.4 km from Serra Mesa

Lauren

3.238.356 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A hotel lobby with a waterfall feature, outdoor seating area, and multiple floors with balconies.

7. Crowne Plaza San Diego - Mission Valley by IHG

6.4 km from Serra Mesa

Chris

3.535.184 ₫ total

includes taxes & fees

15 Oct - 16 Oct

An outdoor patio with a stone fire pit, outdoor seating, string lights, and a tall, narrow heater.

8. Embassy Suites by Hilton San Diego La Jolla

University City, 10.3 km from Serra Mesa

Kunta

6.091.863 ₫ total

includes taxes & fees

31 Oct - 1 Nov

An outdoor seating area with a fire feature, surrounded by palm trees and modern buildings.

9. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

6.4 km from Serra Mesa

Edith

4.875.623 ₫ total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a 'Lobby' sign, palm trees, and a sunset sky.

10. Best Western Seven Seas

5.3 km from Serra Mesa

Mari

2.527.747 ₫ total

includes taxes & fees

12 Oct - 13 Oct

A bar area with a glass ceiling, a central bar counter, and multiple stools.

11. Lafayette Hotel & Club

5.3 km from Serra Mesa

katie

8.007.519 ₫ total

includes taxes & fees

8 Oct - 9 Oct

A hotel with a central courtyard, palm trees, and a fountain.

12. Hilton Garden Inn San Diego Old Town/SeaWorld Area

Old Town San Diego, 7.4 km from Serra Mesa

Kristen

3.846.598 ₫ total

includes taxes & fees

26 Oct - 27 Oct

A hotel courtyard with outdoor seating, palm trees, and a view of the ocean at dusk.

13. Wyndham San Diego Bayside

9.9 km from Serra Mesa

Jonathan

5.490.201 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A resort with two-story buildings, balconies, and a pool area.

14. Humphreys Half Moon Inn

12.3 km from Serra Mesa

Svenja

5.569.474 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A hotel breakfast area with a long counter displaying various food items, including fruits, pastries, and a coffee station.

15. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

6.6 km from Serra Mesa

LaTrisha

4.093.481 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A pool area with lounge chairs and palm trees.

16. Best Western Plus Hacienda Hotel Old Town

Old Town San Diego, 7.6 km from Serra Mesa

shon

4.275.956 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A resort with a large swimming pool surrounded by lounge chairs and palm trees.

17. Handlery Hotel

5.7 km from Serra Mesa

Shane Allen

3.322.523 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A pool area with lounge chairs and a hot tub, overlooking the ocean.

18. The Wayfarer San Diego

Mission Beach, 10.9 km from Serra Mesa

Scott

6.244.670 ₫ total

includes taxes & fees

2 Nov - 3 Nov

A modern hotel room with a large bed, bedside tables, a desk, and a wardrobe.

19. Holiday Inn Express San Diego Airport - Old Town by IHG

7.9 km from Serra Mesa

Patricia

4.720.851 ₫ total

includes taxes & fees

27 Oct - 28 Oct

An outdoor dining area with tables and chairs, overlooking a beach and ocean.

20. Bahia Resort Hotel

Central Mission Beach, 10.7 km from Serra Mesa

Margarita

6.153.952 ₫ total

includes taxes & fees

6 Nov - 7 Nov

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Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

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A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

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Top Serra Mesa Hotel Reviews

Bay Club Hotel & Marina

10/10 Excellent

"Great location and friendly staff."

Best Western Seven Seas

8/10 Good

"King room was a good size. Coffee maker only. A/c filter needed cleaning but worked great after. The staff made it happen right away. No included bkfast. But there's a small diner on the grounds with an impressive menu. Lots of parking but it can fill up at night when people return. A little tricky turning in from the road so go slow and look both ways. It's a large hotel with several 2-story sections. A room in the rear-most section will reduce any road noise. I had a very pleasant stay and would stay there again."

Ocean Beach Hotel

10/10 Excellent

"The cleaning crew were exceptional in performing their duties. Front desk staff very helpful and informative. We enjoyed our stay. I tend to get cabin fever after 3 nights in hotel stay. I love the facts when stepping out of the room your outside and not have to go down long hallways to go outside. Thank you OB hotel"

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 40 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

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Our top choices for Serra Mesa hotels

1. Hampton Inn San Diego-Kearny Mesa

2. Legacy Resort Hotel & Spa

3. DoubleTree by Hilton Hotel San Diego - Mission Valley

4. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

5. San Diego Mission Bay Resort

6. La Quinta Inn & Suites by Wyndham San Diego Mission Bay

7. Crowne Plaza San Diego - Mission Valley by IHG

8. Embassy Suites by Hilton San Diego La Jolla

9. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

10. Best Western Seven Seas

11. Lafayette Hotel & Club

12. Hilton Garden Inn San Diego Old Town/SeaWorld Area

13. Wyndham San Diego Bayside

14. Humphreys Half Moon Inn

15. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

16. Best Western Plus Hacienda Hotel Old Town

17. Handlery Hotel

18. The Wayfarer San Diego

19. Holiday Inn Express San Diego Airport - Old Town by IHG

20. Bahia Resort Hotel

Where to stay in Serra Mesa

Downtown San Diego

Pacific Beach

Mission Beach

Gaslamp Quarter

Mission Bay

Top Serra Mesa Hotel Reviews

Bay Club Hotel & Marina

Frequently asked questions

Explore a world of travel with Expedia