Search Hotels in Serra Mesa, San Diego

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
15 Dec - 16 Dec
Tomorrow
16 Dec - 17 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Serra Mesa hotels

Lobby lounge
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1452)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1949)
"Great hotel"
United States
Farzana
The price is 4.182.813 ₫
6.233.248 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Marriott Marquis San Diego Marina
Front of property
The Sofia Hotel

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.4 out of 10, Very good, (1660)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1014)
"Yes everything was great I will stay there again."
United States
Sergio
The price is 3.130.533 ₫
3.560.982 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Gaslamp Plaza Suites
View from room
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Little Italy, 9.3 km from Serra Mesa
9.0 out of 10, Wonderful, (100)
"It was a nice place to stay at"
United States
Eric
The price is 2.893.770 ₫
3.355.181 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Exterior
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2872)
"Great Location....tons of walking from the hotel Front desk were very nice and polite will be coming back for sure "
United States
Carlos
The price is 4.630.032 ₫
6.801.759 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Manchester Grand Hyatt San Diego
Restaurant
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1229)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is 3.606.164 ₫
4.181.166 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lobby
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1163)
"Amenities and location were great. "
United States
Julie
The price is 4.001.295 ₫
5.706.840 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
View from property
Pacific View Inn

Pacific View Inn

Pacific View Inn
2.0 star property
North Pacific Beach, 11.1 km from Serra Mesa
7.8 out of 10, Good, (1001)
"Wonderful location, clean rooms. "
United States
Maureen
The price is 2.688.049 ₫
3.036.016 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Pacific View Inn
3 restaurants, breakfast, lunch, dinner served; Regional cuisine
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6064)
"Always an amazing stay"
United States
Jana
The price is 3.555.391 ₫
4.885.201 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Wyndham San Diego Bayside
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay, 10.1 km from Serra Mesa
9.0 out of 10, Wonderful, (3925)
"Always love staying here. Staff was very courteous and the rooms very clean. "
United States
Eric
The price is 3.656.673 ₫
4.729.302 ₫ total
includes taxes & fees
16 Dec - 17 Dec
The Dana on Mission Bay
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
Marina District, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1544)
"Clean room, friendly staff, great property. "
United States
MIGUEL
The price is 4.356.439 ₫
6.005.491 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Embassy Suites by Hilton San Diego Bay Downtown
Front of property
The Shoal La Jolla Beach

The Shoal La Jolla Beach

The Shoal La Jolla Beach
2.5 star property
13.2 km from Serra Mesa
8.8 out of 10, Excellent, (1002)
"Near the ocean good place "
United States
Wad
The price is 3.057.400 ₫
3.453.181 ₫ total
includes taxes & fees
18 Dec - 19 Dec
The Shoal La Jolla Beach
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (738)
"Friendly staff and clean rooms. "
Canada
Justine
The price is 2.714.882 ₫
3.147.770 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The DEXTRO Little Italy, BW Premier Collection
5 outdoor pools, a heated pool, pool umbrellas, pool loungers
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 9.8 km from Serra Mesa
8.6 out of 10, Excellent, (2353)
"Great stay, top tier service and excellent customer care "
Canada
Meriem
The price is 3.402.810 ₫
5.303.526 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Paradise Point Resort & Spa
Terrace/patio
Empress Hotel of La Jolla

Empress Hotel of La Jolla

Empress Hotel of La Jolla
3.0 star property
13.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1001)
"Love staying here. It is very convenient to everywhere we need to go in the heart of La Jolla. The staff is friendly and the restaurant is the best!"
United States
Sharon
The price is 3.718.278 ₫
4.727.507 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Empress Hotel of La Jolla
Beach nearby
Inn By The Sea La Jolla

Inn By The Sea La Jolla

Inn By The Sea La Jolla
3.5 star property
13.7 km from Serra Mesa
9.4 out of 10, Exceptional, (1739)
"Delightful stay. Perfect location. "
United States
Nicole
The price is 3.953.942 ₫
4.544.797 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Inn By The Sea La Jolla
On the beach, surfing
Del Mar Beach Hotel

Del Mar Beach Hotel

Del Mar Beach Hotel
2.0 star property
21.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1003)
"It was a good place to relax with local friendly people and the hotel was immaculate "
Australia
Matt
Del Mar Beach Hotel
Property entrance
Beach Haven - Near Pacific Beach Park

Beach Haven - Near Pacific Beach Park

Beach Haven - Near Pacific Beach Park
2.0 star property
North Pacific Beach, 11 km from Serra Mesa
8.8 out of 10, Excellent, (1002)
"The staff was great, hotel was quiet and cozy "
United States
Estela
The price is 2.462.335 ₫
2.781.084 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Beach Haven - Near Pacific Beach Park
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1064)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.556.706 ₫
4.886.463 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Westin San Diego Bayview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Clean rooms, friendly staff"
Marie 1-night trip
Posted 6 hours ago
Courtyard by Marriott San Diego Downtown Little Italy

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 39 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.