Search Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1,483 reviews)
"Great location. Good value for money."
United States
Mohammad
The Bristol Hotel San Diego

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay, 10.3 km from Serra Mesa
8.4 out of 10, Very good, (1,597 reviews)
"Balcony view is awesome, clean room, staff at counter and restaurant service was stunning."
United States
francisco
The price is 4.130.025 ₫
6.121.594 ₫ total
includes taxes & fees
8 Feb - 9 Feb
Hyatt Regency Mission Bay Spa and Marina

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
9.3 km from Serra Mesa
9.0 out of 10, Wonderful, (1,025 reviews)
"Clean rooms and friendly staff"
United States
Topeka
The price is 3.012.056 ₫
3.492.329 ₫ total
includes taxes & fees
22 Feb - 23 Feb
The DEXTRO Little Italy, BW Premier Collection

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 10.8 km from Serra Mesa
9.0 out of 10, Wonderful, (3,291 reviews)
"Great place to stay!"
United States
CINDY
The price is 15.213.479 ₫
18.871.939 ₫ total
includes taxes & fees
18 Feb - 19 Feb
Hard Rock Hotel San Diego

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 9.9 km from Serra Mesa
8.8 out of 10, Excellent, (2,402 reviews)
"Clean rooms, friendly staff, and a beautiful view all around.. "
United States
Morgan
The price is 3.727.412 ₫
5.659.070 ₫ total
includes taxes & fees
1 Mar - 2 Mar
Paradise Point Resort & Spa

Holiday Inn Express San Diego Downtown by IHG

Holiday Inn Express San Diego Downtown by IHG
2.5 star property
9.4 km from Serra Mesa
8.4 out of 10, Very good, (1,597 reviews)
"Lovely stay, friendly staff and great breakfast "
Canada
Louella
The price is 3.505.410 ₫
4.064.347 ₫ total
includes taxes & fees
2 Mar - 3 Mar
Holiday Inn Express San Diego Downtown by IHG

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay, 10.1 km from Serra Mesa
9.0 out of 10, Wonderful, (4,064 reviews)
"Great location and grounds!"
United States
Ethan
The price is 4.258.424 ₫
5.491.809 ₫ total
includes taxes & fees
22 Feb - 23 Feb
The Dana on Mission Bay

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6,025 reviews)
"Great place to stay"
United States
David
The price is 3.950.727 ₫
5.484.286 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Wyndham San Diego Bayside

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,618 reviews)
"Very easy vacation, convenient breakfast as well as location."
United States
Kathy
The price is 4.450.053 ₫
6.101.659 ₫ total
includes taxes & fees
1 Mar - 2 Mar
Embassy Suites by Hilton San Diego Bay Downtown

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 7.2 km from Serra Mesa
8.4 out of 10, Very good, (1,341 reviews)
"Great place for our family getaway! Loved the S’mores on the beach! "
United States
Dani
The price is 5.167.234 ₫
7.312.545 ₫ total
includes taxes & fees
22 Feb - 23 Feb
San Diego Mission Bay Resort

Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
19.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,075 reviews)
"Clean room, gorgeous grounds, very friendly staff "
United States
Taryn
The price is 4.909.275 ₫
6.713.502 ₫ total
includes taxes & fees
8 Feb - 9 Feb
Loews Coronado Bay Resort

Westgate Hotel

Westgate Hotel
4.5 star property
9.9 km from Serra Mesa
9.0 out of 10, Wonderful, (1,006 reviews)
"Great stay"
United States
ESMERALDA
Westgate Hotel

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1,004 reviews)
"Great location and stay. "
United States
Simran
The price is 2.687.481 ₫
3.866.418 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Staypineapple, Hotel Z, Gaslamp San Diego

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1,218 reviews)
"Perfect location in the Gaslamp District. Rooms were large & clean with friendly staff. "
United States
Ginger
The price is 4.885.897 ₫
6.719.019 ₫ total
includes taxes & fees
8 Feb - 9 Feb
Margaritaville Hotel San Diego Gaslamp Quarter

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
12.6 km from Serra Mesa
9.2 out of 10, Wonderful, (3,363 reviews)
"We had great time and enjoyed our stay "
United States
sadra
The price is 3.295.085 ₫
3.787.535 ₫ total
includes taxes & fees
16 Feb - 17 Feb
Bay Club Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
12.9 km from Serra Mesa
9.0 out of 10, Wonderful, (1,580 reviews)
"Great place.very clean great for family would definitely stay there again."
United States
Joseph
The price is 3.697.558 ₫
4.250.158 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Best Western Plus Island Palms Hotel & Marina

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.2 out of 10, Wonderful, (1,714 reviews)
"Very clean resort. "
United States
Petrina
Sycuan Casino Resort

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley, 17.4 km from Serra Mesa
8.4 out of 10, Very good, (2,039 reviews)
"Nice hotel, staff is great."
United States
Felipe Ramirez
The price is 3.385.447 ₫
3.857.547 ₫ total
includes taxes & fees
1 Mar - 2 Mar
DoubleTree by Hilton San Diego - Del Mar

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,926 reviews)
"The staff was very nice and great location"
United States
Curtis
The price is 2.280.386 ₫
2.621.190 ₫ total
includes taxes & fees
11 Feb - 12 Feb
GreenTree Inn San Diego Mission Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.