Search Hotels in Serra Mesa, San Diego

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19 Dec - 20 Dec
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20 Dec - 21 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Serra Mesa hotels

Check-in/check-out kiosk
Urban Boutique Hotel

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1266)
"Locations is excellent and the front desk lady was friendly "
Canada
Ju
Urban Boutique Hotel
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1016)
"Yes everything was great I will stay there again."
United States
Sergio
The price is 3.106.232 ₫
3.533.339 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Gaslamp Plaza Suites
Standard Room, 2 Queen Beds | Pillow-top beds, individually decorated, individually furnished, desk
GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1872)
"Courteous staff and clean room. "
United States
Rachel
The price is 2.324.146 ₫
2.671.489 ₫ total
includes taxes & fees
24 Dec - 25 Dec
GreenTree Inn San Diego Mission Bay
Exterior
La Pensione Hotel

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1890)
"Great check-in experience, convenient parking, the room was clean and bed was comfortable. The city view option was exceptionally pleasant. Will stay again! "
United States
Mike
La Pensione Hotel
Front of property
Heritage Inn San Diego

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.4 out of 10, Good, (1168)
"Clean room, great location "
United States
Benjamin
The price is 1.361.997 ₫
1.565.548 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Heritage Inn San Diego
Lobby
Best Western Plus Bayside Inn

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
9.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1000)
"Great staff and location."
United States
Lisa
The price is 3.346.044 ₫
3.873.046 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Bayside Inn
Desk, laptop workspace, blackout curtains, iron/ironing board
SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1418)
"our stay was great and staff was supportive..."
United States
Ramesh
The price is 2.084.598 ₫
2.354.449 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
SureStay Hotel by Best Western San Diego Pacific Beach
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4109)
"Room was very clean and staff very pleasant "
Canada
Brian
The price is 2.342.836 ₫
2.692.974 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Wyndham Garden San Diego Near SeaWorld
Outdoor pool, pool umbrellas, pool loungers
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown
2.5 star property
9.6 km from Serra Mesa
8.2 out of 10, Very good, (2290)
"The room was great, the bed was comfortable."
United States
PAM
The price is 2.634.793 ₫
3.054.910 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn San Diego-Downtown
Standard Room, 2 Queen Beds, Non Smoking | In-room safe, desk, laptop workspace, blackout curtains
Comfort Inn Sea World Area

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3151)
"good hotel "
United States
Lala
The price is 2.237.540 ₫
2.571.941 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn Sea World Area
Meeting facility
The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar
3.0 star property
Gaslamp Quarter, 9.9 km from Serra Mesa
8.8 out of 10, Excellent, (556)
"beautiful hotel, well maintained facilities, convenient location, very kind staff"
United States
Sergio
The price is 3.137.821 ₫
3.569.271 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
The Beau Downtown San Diego Gaslamp Quar
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
3.5 star property
Marina District, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (2702)
"Great place if you want to stay near glaslamp quarter district."
Mexico
Daniel
The Horton Grand, Downtown/Gaslamp Quarter
Front of property
The Sofia Hotel

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.4 out of 10, Very good, (1657)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1068)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.348.413 ₫
4.645.450 ₫ total
includes taxes & fees
29 Dec - 30 Dec
The Westin San Diego Bayview
Marina
Sea Harbor Hotel

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
12.2 km from Serra Mesa
8.6 out of 10, Excellent, (1004)
"Great stay"
United States
Naomi
Sea Harbor Hotel
Exterior
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
11.9 km from Serra Mesa
7.8 out of 10, Good, (1189)
"Great location on the bay and close to the airport "
United States
Shawn
The price is 2.114.475 ₫
2.388.194 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Comfort Inn San Diego Airport At The Harbor
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1456)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 7.4 km from Serra Mesa
8.0 out of 10, Very good, (1433)
"Great place We will stay here again. "
United States
Derek
The price is 2.386.007 ₫
2.743.180 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Desk, blackout curtains, iron/ironing board, cots/infant beds
Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
11.8 km from Serra Mesa
8.6 out of 10, Excellent, (1636)
"The breakfast options were good and the staff were very helpful."
Canada
Gail or Rob
The price is 2.630.031 ₫
3.018.047 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Yacht Harbor Hotel
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1234)
"Nice Residence Inn"
United States
Terry
The price is 3.608.494 ₫
4.183.868 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"The room was comfortable & the staff was incredibly friendly. The location is also ideal for exploration and looking around. Really solid pick."
Michael 5-night trip
Posted 23 hours ago
The DEXTRO Little Italy, BW Premier Collection

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.