Search Hotels in Serra Mesa, San Diego

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12 Dec - 13 Dec
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13 Dec - 14 Dec
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12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Serra Mesa hotels

3 restaurants, breakfast, lunch, dinner served; Regional cuisine
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6050)
"Always an amazing stay"
United States
Jana
The price is 3.558.364 ₫
4.889.287 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Wyndham San Diego Bayside
Poolside bar
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 10.8 km from Serra Mesa
9.0 out of 10, Wonderful, (3148)
"Great stay"
United States
Laurence
The price is 4.478.563 ₫
6.402.950 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hard Rock Hotel San Diego
Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3515)
"Great friendly staff "
United States
mohammed
The price is 2.820.099 ₫
3.107.608 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Marina Gateway Hotel
American cuisine
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
3.5 star property
Marina District, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (2696)
"Clean facilities and friendly staff!"
United States
EMMA
The Horton Grand, Downtown/Gaslamp Quarter
Restaurant
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1229)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is 3.609.179 ₫
4.184.662 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lobby lounge
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1447)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Lobby
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
5.7 km from Serra Mesa
9.2 out of 10, Wonderful, (2943)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is 4.005.957 ₫
4.604.647 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Legacy Resort Hotel & Spa
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1013)
"Yes everything was great I will stay there again."
United States
Sergio
The price is 3.133.151 ₫
3.563.960 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Gaslamp Plaza Suites
Front of property
The Sofia Hotel

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.4 out of 10, Very good, (1654)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1000)
"Great location "
United States
Mohammad
The price is 2.108.953 ₫
3.206.133 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Exterior
Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island
2.5 star property
12.3 km from Serra Mesa
8.8 out of 10, Excellent, (1001)
"Good to spend a night or two-- nice staff-- friendly ad awesome breakfast"
United States
MICHELE
The price is 4.130.230 ₫
4.543.253 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Best Western Plus Suites Hotel Coronado Island
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1943)
"Great hotel"
United States
Farzana
The price is 4.186.311 ₫
6.238.459 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Marriott Marquis San Diego Marina
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle
3.0 star property
5.4 km from Serra Mesa
8.0 out of 10, Very good, (2433)
"All was very nice. "
United States
Milton
The price is 2.327.484 ₫
2.675.327 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Days Inn by Wyndham San Diego Hotel Circle
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (727)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.573.883 ₫
2.984.290 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1061)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.559.681 ₫
4.890.550 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Lobby sitting area
Kings Inn San Diego

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
6 km from Serra Mesa
8.8 out of 10, Excellent, (3565)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is 1.971.121 ₫
2.261.861 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Kings Inn San Diego
Exterior
Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.2 out of 10, Wonderful, (1007)
"room is clean and staff really nice to guest. "
United States
Yu
The price is 3.400.053 ₫
3.740.059 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express San Diego South - Chula Vista by IHG
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
12.6 km from Serra Mesa
9.2 out of 10, Wonderful, (3179)
"Great stay and location!"
United States
Jason
The price is 3.293.758 ₫
3.785.847 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Bay Club Hotel & Marina
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
29.1 km from Serra Mesa
9.2 out of 10, Wonderful, (1630)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Single Room, 1 King Bed, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
18.6 km from Serra Mesa
7.2 out of 10, Good, (1983)
"Great stay"
United States
Eleazar
The price is 1.687.162 ₫
1.855.931 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Palmeras Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Leigh at the front desk."
Randolph 1-night trip
Posted 3 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

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Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 39 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.