Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Check prices for these dates

Tonight
17 Dec - 18 Dec
Tomorrow
18 Dec - 19 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Sioux Empire Medical Museum hotels

Terrace/patio
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
3.0 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (585)
"This is a great hotel - centrally located and very clean and quiet. Will definitely be staying there again. "
United States
Tracey
The price is 2.570.160 ₫
2.872.142 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center
Interior detail
Hotel On Phillips

Hotel On Phillips

Hotel On Phillips
2.5 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
9.6 out of 10, Exceptional, (1297)
"Great staff and location!"
United States
Gerald
Hotel On Phillips
Exterior detail
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls
3.0 star property
Mall District, 2.8 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1000)
"Absolutely beautiful places to stay with family excellent service staff great food service great hospitality great "
United States
Rosario
Clubhouse Hotel Suites Sioux Falls
Meeting facility
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown
4.0 star property
Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (157)
"Room was very clean, great overall stay."
United States
Destiny
The price is 3.433.036 ₫
3.924.027 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Canopy By Hilton Sioux Falls Downtown
Meeting facility
Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown

Hilton Garden Inn Sioux Falls Downtown
3.0 star property
Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum
9.0 out of 10, Wonderful, (883)
"Friendly front desk staff, clean room, great location, safe "
United States
Hannah
The price is 2.739.419 ₫
3.163.128 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hilton Garden Inn Sioux Falls Downtown
Exterior
Hampton Inn Sioux Falls

Hampton Inn Sioux Falls

Hampton Inn Sioux Falls
2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (1003)
"It was a very nice stay. "
United States
Lenore
The price is 2.570.160 ₫
2.872.142 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hampton Inn Sioux Falls
Porch
Historic Victorian Inn

Historic Victorian Inn

Historic Victorian Inn
3.0 star property
Cathedral, 1.5 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (56)
"It was a great place to stay and super interesting."
United States
Kathy
The price is 2.867.551 ₫
3.577.667 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Historic Victorian Inn
Exterior
Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG

Holiday Inn Sioux Falls-City Centre by IHG
3.0 star property
Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1002)
"Always a great stay. "
United States
Shawn
The price is 2.396.849 ₫
2.682.022 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Sioux Falls-City Centre by IHG
Exterior
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
2.5 star property
Mall District, 3.1 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (1000)
"Breakfast good, staff very accommodating and friendly. "
United States
Geraldine
The price is 3.371.392 ₫
3.751.200 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG
Exterior
Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD
3.0 star property
Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum
8.4 out of 10, Very good, (1155)
"It was a great place to stay!"
United States
Trinity
The price is 2.264.615 ₫
2.536.962 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Country Inn & Suites by Radisson, Sioux Falls, SD
Lobby
Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center

Sheraton Sioux Falls Hotel & Convention Center
4.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
8.6 out of 10, Excellent, (1000)
"Great hotel. Staff was excellent "
United States
Kristina
The price is 2.551.474 ₫
2.851.628 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Sheraton Sioux Falls Hotel & Convention Center
Suite 2 Queens, Recliner, Pullout Sofa | Free WiFi, bed sheets
The Center Inn

The Center Inn

The Center Inn
2.5 star property
All Saints, 2.4 km from Sioux Empire Medical Museum
8.4 out of 10, Very good, (701)
"Room and staff were great. "
United States
Annette
The Center Inn
Basic Studio, 1 King Bed | Desk, free WiFi, wheelchair access
Valley Inn

Valley Inn

Valley Inn
2.5 star property
University Heights, 0.2 km from Sioux Empire Medical Museum
7.6 out of 10, Good, (1001)
"Room was clean, staff was friendly, very convenient location "
United States
Theresa
Valley Inn
3 indoor pools, open 9:00 AM to 10:00 PM, pool loungers
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
3.0 star property
Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum
7.8 out of 10, Good, (1456)
"staff was friendly "
United States
Rob
The price is 1.575.910 ₫
1.781.436 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
50-inch flat-screen TV with cable channels, fireplace, Netflix
Historic Twin Tudors Inn

Historic Twin Tudors Inn

Historic Twin Tudors Inn
3.0 star property
1.4 km from Sioux Empire Medical Museum
8.8 out of 10, Excellent, (3)
"Lovely place! Wish we could have stayed longer. Steve was attentive and helpful. "
United States
Anonymous traveller
The price is 7.087.825 ₫
8.037.416 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Historic Twin Tudors Inn
Pool
Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites

Ramada by Wyndham Sioux Falls Arpt & Suites
2.0 star property
Northwest Sioux Falls, 3 km from Sioux Empire Medical Museum
7.0 out of 10, Good, (52)
"Very friendly at check in. Great service at bar."
United States
Chris
Ramada by Wyndham Sioux Falls Arpt & Suites
Lobby
Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls

Ramada by Wyndham Sioux Falls
2.0 star property
2.6 km from Sioux Empire Medical Museum
5.6 out of 10, (1001)
"Good room for the price."
United States
Michael
The price is 1.343.289 ₫
1.526.266 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Ramada by Wyndham Sioux Falls
Terrace/patio
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South
3.0 star property
Mall District, 3.7 km from Sioux Empire Medical Museum
9.4 out of 10, Exceptional, (1004)
"Great stay!"
United States
Nick
The price is 3.080.727 ₫
3.432.220 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hyatt Place Sioux Falls South
Exterior
Holiday Inn & Suites Sioux Falls - Airport by IHG

Holiday Inn & Suites Sioux Falls - Airport by IHG

Holiday Inn & Suites Sioux Falls - Airport by IHG
3.0 star property
Northwest Sioux Falls, 3.4 km from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (840)
"Was the perfect place to stay for late arrival into airport. Nothing fancy but met expectations and there was a restaurant next door that you can walk to. "
United States
Joshua
The price is 2.607.561 ₫
2.913.173 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn & Suites Sioux Falls - Airport by IHG
Exterior
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls
3.0 star property
Mall District, 4 km from Sioux Empire Medical Museum
9.2 out of 10, Wonderful, (1543)
"The room was clean and the staff was Great would stay there again . The breakfast was OK could be better !"
United States
William
The price is 2.167.568 ₫
2.430.485 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
La Quinta Inn & Suites by Wyndham Sioux Falls
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sioux Empire Medical Museum Hotel Reviews

Hotels near other Sioux Empire Medical Museum attractions

Great Plains Zoo

4.3/5 (74 reviews)
Why not meet the animals who live at Great Plains Zoo during your holiday in Sioux Falls? Attend a sporting event or discover the area's beautiful waterfalls.
See properties

University of Sioux Falls

4.1/5 (170 reviews)
Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.
See properties

Frequently asked questions

What's the area like around Sioux Empire Medical Museum?
Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 106 hotels and other accommodation options you'll find within a mile.
How many hotels are there close to Sioux Empire Medical Museum?
Expedia has 106 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.
If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.
What can I see and do near Sioux Empire Medical Museum?
Washington Pavilion of Arts and Science, Center for Western Studies and Old Courthouse Museum feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can wander around Falls Park, Sherman Park or Fawick Park if you want a dose of fresh air.