Search Hotels in South Main, Houston
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Our top choices for South Main hotels
1. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,002 reviews)
"Clean rooms and staff is great."
Tamy
The price is 2.074.560 ₫
2.427.235 ₫ total
includes taxes & fees
3 Nov - 4 Nov
2. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
7.2 out of 10, Good, (1,452 reviews)
"Great stay!!"
Matthew
The price is 2.309.116 ₫
2.701.665 ₫ total
includes taxes & fees
15 Oct - 16 Oct
3. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"We had a excellent stay"
Jasmine
The price is 1.731.998 ₫
2.026.845 ₫ total
includes taxes & fees
20 Oct - 21 Oct
4. Wingate Houston near Reliant Park/Medical Center
Wingate Houston near Reliant Park/Medical CenterSouth Main
6.6 out of 10, (1,006 reviews)
"Great place"
Crystal
The price is 2.306.524 ₫
2.698.633 ₫ total
includes taxes & fees
15 Oct - 16 Oct
5. 3 BR Condo near Reliant/NRG Stadium
3 BR Condo near Reliant/NRG StadiumSouth Main
8.0 out of 10, Very good, (1 review)
"Checkin was unpleasant because I was given the wrong lockbox information and had trouble reaching the management company. Finally I did and after an hour I got the key. They the WiFi didn’t work and I couldn’t reach anyone - another frustrating hour wasted. The hidden router just needed to be plugged in. The place itself was very comfortable and very convenient for the Reliant Stadium."
Jeffrey
The price is 2.960.333 ₫
9.679.544 ₫ total
includes taxes & fees
15 Oct - 16 Oct
6. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (899 reviews)
"Amazing friendly staff."
Olga
The price is 1.918.968 ₫
2.245.193 ₫ total
includes taxes & fees
18 Oct - 19 Oct
7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,001 reviews)
"Very clean, friendly staff and great breakfast."
Elisa
The price is 2.956.248 ₫
3.479.815 ₫ total
includes taxes & fees
19 Oct - 20 Oct
8. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great Hotel!"
Jorge
The price is 2.658.982 ₫
3.143.203 ₫ total
includes taxes & fees
28 Oct - 29 Oct
9. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,703 reviews)
"Great stay!"
Anthony
The price is 3.274.053 ₫
3.850.943 ₫ total
includes taxes & fees
27 Oct - 28 Oct
10. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,285 reviews)
"Great location and the bed was amazingly comfortable!!"
Debra
The price is 3.274.151 ₫
3.851.057 ₫ total
includes taxes & fees
28 Oct - 29 Oct
11. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very good, (1,573 reviews)
"clean hotel, very nice I enjoyed my stay!"
aundrea
The price is 1.823.424 ₫
2.262.986 ₫ total
includes taxes & fees
28 Oct - 29 Oct
12. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,201 reviews)
"Room was great, staff was helpful"
Marvin
The price is 2.843.444 ₫
3.356.909 ₫ total
includes taxes & fees
8 Nov - 9 Nov
13. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,251 reviews)
"Great place"
Matthew
The price is 4.163.405 ₫
5.182.189 ₫ total
includes taxes & fees
8 Nov - 9 Nov
14. The Royal Sonesta Houston Galleria
The Royal Sonesta Houston GalleriaThe Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,330 reviews)
"Wonderful stay will stay again!"
Brandon
The price is 3.731.904 ₫
4.366.328 ₫ total
includes taxes & fees
17 Oct - 18 Oct
15. Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
9.2 out of 10, Wonderful, (1,013 reviews)
"Great place!"
Madiha
The price is 5.439.250 ₫
7.542.883 ₫ total
includes taxes & fees
29 Oct - 30 Oct
16. DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria8.9 km from South Main
8.4 out of 10, Very good, (4,584 reviews)
"Wonderful-beautiful and clean hotel, excellent customer service-highly recommend"
Nerissa
The price is 3.141.719 ₫
3.701.484 ₫ total
includes taxes & fees
22 Oct - 23 Oct
17. The Moran CITYCENTRE
The Moran CITYCENTRE18.3 km from South Main
9.2 out of 10, Wonderful, (1,210 reviews)
"Great property and location"
sophia
The price is 4.742.628 ₫
6.320.913 ₫ total
includes taxes & fees
14 Nov - 15 Nov
18. Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (460 reviews)
"Happy to stayed there!"
AYTUNC
The price is 2.216.077 ₫
2.592.808 ₫ total
includes taxes & fees
18 Oct - 19 Oct
19. Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria8.7 km from South Main
9.2 out of 10, Wonderful, (1,541 reviews)
"Wonderful Staff. Very nice place to stay. Close to mall, restaurants, NRG Stadium & Hobby Airport"
Christy
The price is 3.602.324 ₫
4.244.781 ₫ total
includes taxes & fees
14 Nov - 15 Nov
20. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHG6.5 km from South Main
7.8 out of 10, Good, (1,706 reviews)
"Super nice stay"
Dustin
The price is 1.736.372 ₫
2.031.554 ₫ total
includes taxes & fees
11 Nov - 12 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,002 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 899 reviews | View | ||||||
 Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,452 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,000 reviews | View | ||||||
 Wingate Houston near Reliant Park/Medical Center | 6.6 1,006 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Wyndham Houston at Reliant Park & Medical Center
8/10 Good
