Search Hotels in South Main, Houston
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Our top choices for South Main hotels
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is 1.577.537 ₫
1.845.718 ₫ total
includes taxes & fees
19 Jul - 20 Jul
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,011 reviews)
"Good parking"
joseph
The price is 1.857.071 ₫
2.172.773 ₫ total
includes taxes & fees
5 Jul - 6 Jul
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (871 reviews)
"My stay was perfect "
Fredrick
The price is 1.947.902 ₫
2.279.045 ₫ total
includes taxes & fees
12 Jul - 13 Jul
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,294 reviews)
"Would stay again!"
Austin
The price is 2.605.977 ₫
3.048.992 ₫ total
includes taxes & fees
12 Jul - 13 Jul
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,012 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is 2.886.843 ₫
3.377.606 ₫ total
includes taxes & fees
12 Jul - 13 Jul
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (119 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
Rorie
The price is 1.747.584 ₫
2.044.771 ₫ total
includes taxes & fees
6 Jul - 7 Jul
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.8 out of 10, (1,197 reviews)
"Great, great , great"
Joshua
The price is 1.281.920 ₫
1.499.846 ₫ total
includes taxes & fees
9 Jul - 10 Jul
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (726 reviews)
"It was clean and the staff was helpful."
Yuan Chao
The price is 1.279.298 ₫
1.471.192 ₫ total
includes taxes & fees
25 Jun - 26 Jun
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (42 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is 2.130.138 ₫
2.492.261 ₫ total
includes taxes & fees
25 Jun - 26 Jun
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (289 reviews)
"Great experience with friendly staff."
Maria
The price is 2.084.782 ₫
2.438.826 ₫ total
includes taxes & fees
12 Jul - 13 Jul
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
Deanndra
The price is 2.251.372 ₫
2.634.105 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very good, (219 reviews)
"The room was clean parked right in front of the door of the room and staff was very happy and helpful"
Sonji Machelle
The price is 1.812.101 ₫
2.120.157 ₫ total
includes taxes & fees
2 Jul - 3 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very good, (2,138 reviews)
"Great Hotel!"
Alexa
The price is 2.226.926 ₫
2.605.504 ₫ total
includes taxes & fees
7 Jul - 8 Jul
Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownMidtown, 9.1 km from South Main
9.2 out of 10, Wonderful, (168 reviews)
"Great place. The staff is very friendly and the place is clean."
Fernando
The price is 2.524.608 ₫
2.953.791 ₫ total
includes taxes & fees
1 Jul - 2 Jul
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is 2.290.101 ₫
2.679.418 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,485 reviews)
"The kitchen staff was wonderful and one of the nicest breakfast I've had at any hotel!"
Christy
The price is 1.842.610 ₫
2.155.854 ₫ total
includes taxes & fees
6 Jul - 7 Jul
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,234 reviews)
"Great location"
Maxwell
The price is 2.215.080 ₫
2.547.276 ₫ total
includes taxes & fees
5 Jul - 6 Jul
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,915 reviews)
"Close to the airport and near many restaurants."
Lori
The price is 2.351.960 ₫
2.766.375 ₫ total
includes taxes & fees
19 Jul - 20 Jul
Haven Inn & Suites Downtown Houston
Haven Inn & Suites Downtown Houston18.7 km from South Main
9.4 out of 10, Exceptional, (1,055 reviews)
"Great stay!"
Dalisia
The price is 1.868.933 ₫
2.186.652 ₫ total
includes taxes & fees
14 Jul - 15 Jul
Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear LakeNassau Bay, 31.8 km from South Main
8.2 out of 10, Very good, (1,022 reviews)
"This is the third time I stayed here and I always love my stay!"
Deena
The price is 1.710.995 ₫
2.001.864 ₫ total
includes taxes & fees
21 Jun - 22 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,012 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,294 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 871 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,011 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Downtown Aquarium to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
8/10 Good
