Search Hotels in South Main, Houston
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Our top choices for South Main hotels
1. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
7.2 out of 10, Good, (1,395 reviews)
"Nice stay"
Timothy
The price is 2.452.636 ₫
2.869.585 ₫ total
includes taxes & fees
7 Sept - 8 Sept
2. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (896 reviews)
"Great amenities!"
Michelle
The price is 2.164.474 ₫
2.532.435 ₫ total
includes taxes & fees
14 Sept - 15 Sept
3. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,000 reviews)
"The room was very clean.The breakfast was really good.The staff was nice and the parking good !"
Linda
The price is 2.530.609 ₫
2.960.812 ₫ total
includes taxes & fees
8 Sept - 9 Sept
4. Wingate Houston at Reliant Park & Medical Center
Wingate Houston at Reliant Park & Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"My overall stay was good and property was well maintained and cleaned and staff was super helpful"
Terry
The price is 2.399.176 ₫
2.807.036 ₫ total
includes taxes & fees
1 Sept - 2 Sept
5. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Regular aceptable ."
Oscar
The price is 1.806.162 ₫
2.113.209 ₫ total
includes taxes & fees
14 Sept - 15 Sept
6. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,628 reviews)
"Very good place to stay. Staff was excellent, the facilities were great, and the morning breakfast got us going!"
William
The price is 3.262.358 ₫
3.837.189 ₫ total
includes taxes & fees
6 Sept - 7 Sept
7. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very good, (1,562 reviews)
"Great staff and room"
Meryem
The price is 2.035.782 ₫
2.512.255 ₫ total
includes taxes & fees
9 Sept - 10 Sept
8. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Great Hotel!"
Jorge
The price is 2.748.621 ₫
3.249.282 ₫ total
includes taxes & fees
4 Sept - 5 Sept
9. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,884 reviews)
"Perfect location, excellent rooms and free car service to MDA appts."
Isabel
The price is 3.650.346 ₫
4.270.906 ₫ total
includes taxes & fees
6 Sept - 7 Sept
10. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,277 reviews)
"Very reliable hotel"
Leland
The price is 3.294.518 ₫
3.875.017 ₫ total
includes taxes & fees
5 Sept - 6 Sept
11. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,187 reviews)
"Loved the location and hospitality of the staff. Enjoyed the restaurant in the hotel."
Stanley
The price is 3.569.818 ₫
4.443.351 ₫ total
includes taxes & fees
6 Sept - 7 Sept
12. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,122 reviews)
"Our stay was great"
Cindy
The price is 2.095.628 ₫
2.482.133 ₫ total
includes taxes & fees
6 Sept - 7 Sept
13. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,608 reviews)
"Stay was nice’! Will stay again"
Lanita
The price is 1.747.226 ₫
2.044.254 ₫ total
includes taxes & fees
8 Sept - 9 Sept
14. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very good, (1,842 reviews)
"Great stay"
Raphael
The price is 2.327.201 ₫
2.722.825 ₫ total
includes taxes & fees
4 Sept - 5 Sept
15. Drury Inn & Suites Houston Near the Galleria
Drury Inn & Suites Houston Near the GalleriaThe Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,540 reviews)
"Great location, wonderful breakfast"
Andrei
The price is 2.451.071 ₫
2.867.753 ₫ total
includes taxes & fees
6 Sept - 7 Sept
16. Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston GalleriaThe Galleria, 8.4 km from South Main
8.4 out of 10, Very good, (1,375 reviews)
"Clean room, helpful staff, and excellent breakfast."
Mikhail
The price is 2.762.337 ₫
3.231.849 ₫ total
includes taxes & fees
12 Sept - 13 Sept
17. Homewood Suites by Hilton Houston Memorial
Homewood Suites by Hilton Houston Memorial16.4 km from South Main
9.6 out of 10, Exceptional, (1,002 reviews)
"Excellent property, rooms, staff, breakfast, location, etc......."
Roland
The price is 2.355.365 ₫
2.755.777 ₫ total
includes taxes & fees
6 Sept - 7 Sept
18. Hyatt Regency Houston West
Hyatt Regency Houston West23.2 km from South Main
8.6 out of 10, Excellent, (1,603 reviews)
"Nice stay"
Tami
The price is 2.234.363 ₫
2.614.205 ₫ total
includes taxes & fees
12 Sept - 13 Sept
19. The Chifley Houston, Tapestry Collection by Hilton
The Chifley Houston, Tapestry Collection by HiltonThe Galleria, 8.7 km from South Main
9.2 out of 10, Wonderful, (1,337 reviews)
"Overall great hotel in a convenient location"
Emily
The price is 2.758.531 ₫
3.227.481 ₫ total
includes taxes & fees
5 Sept - 6 Sept
20. Quality Suites Houston Hobby Airport
Quality Suites Houston Hobby AirportSoutheast Houston, 13.3 km from South Main
8.4 out of 10, Very good, (1,265 reviews)
"It was nice for a short trip"
Carlos
The price is 1.746.542 ₫
2.043.320 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,000 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 896 reviews | View | ||||||
 Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,395 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View | ||||||
 Wingate Houston at Reliant Park & Medical Center | 6.6 1,000 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or The Chapel of St. Basil while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
10/10 Excellent
