Search Hotels in South Main, Houston

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near South Main, Houston

Lobby
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

2.5 star property
South Main
8.6 out of 10, Excellent, (1012)
"Was a great stay and rigjt next to the stadium all around recomended"
United States
Jason
The price is 2.365.394 ₫
2.767.511 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Comfort Suites Houston near Medical Center- NRG Stadium
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
South Main
6.6 out of 10, (1000)
"Everything was great"
United States
Yeimi
The price is 1.643.829 ₫
1.923.280 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Quality Inn & Suites NRG Park - Medical Center
Lobby
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 star property
South Main
7.2 out of 10, Good, (1196)
"Love this place. Been staying here for many years. "
United States
Reynaldo
The price is 2.347.197 ₫
2.746.221 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Wyndham Houston near NRG Park/Medical Center
Gazebo
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
South Main
6.6 out of 10, (984)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is 1.819.737 ₫
2.129.094 ₫ total
includes taxes & fees
6 Dec - 7 Dec
Wingate Houston near NRG Park/Medical Center
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

2.5 star property
South Main
7.4 out of 10, Good, (820)
"Yes the where"
United States
Robert
The price is 1.772.266 ₫
2.073.551 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Candlewood Suites Houston Medical Center by IHG
Lobby
Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2160)
"Nice hotel, excellent rooms with comfy beds! Only stayed one night but definitely a nice place"
United States
Carey
The price is 3.061.905 ₫
3.601.414 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hyatt Place Houston Medical Center
Lobby
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3588)
"Everything about our stay was excellent. "
United States
Clarence
The price is 3.474.458 ₫
4.065.117 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Blossom Hotel Houston, Curio Collection by Hilton
Lobby
Hyatt House Houston Medical Center

Hyatt House Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1176)
"I had a great stay! I travel to Houston several times a year and this is one of my favorite places to stay."
United States
Star
The price is 3.061.905 ₫
3.601.414 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Hyatt House Houston Medical Center
Exterior
The Lancaster Hotel

The Lancaster Hotel

4.0 star property
Downtown Houston, 11.1 km from South Main
9.8 out of 10, Exceptional, (1000)
"Great amenities and hospitality "
United States
Varun
The price is 7.694.586 ₫
9.002.951 ₫ total
includes taxes & fees
6 Dec - 7 Dec
The Lancaster Hotel
Sun deck
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 star property
4.4 km from South Main
8.4 out of 10, Very good, (1719)
"Clean rooms, comfortable bed, & friendly staff"
United States
Thomas
The price is 2.458.755 ₫
2.907.337 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton Houston Plaza/Medical Center
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1160)
"Confortable bed, quiet ron and nice breakfast!"
United States
Juan
The price is 3.396.842 ₫
4.776.308 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Hyatt Regency Houston/Galleria
Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.9 km from South Main
8.2 out of 10, Very good, (3022)
"Wonderful property will be booking again"
United States
Tyanna
The price is 3.290.625 ₫
3.876.934 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very good, (1438)
"Great place to stay!"
United States
Curtis
The price is 3.402.117 ₫
3.980.476 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Royal Sonesta Houston Galleria
City view from property
The Whitehall Houston

The Whitehall Houston

4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1895)
"Great stay."
United States
Anita
The price is 2.935.537 ₫
3.434.578 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
The Whitehall Houston
Terrace/patio
Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX

3.0 star property
Texas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (1000)
"Clean room and nice staff"
Canada
Guillermo
The price is 2.721.694 ₫
3.184.383 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hilton Garden Inn Houston Medical Center, TX
Reception
InterContinental Houston by IHG

InterContinental Houston by IHG

4.0 star property
Texas Medical Center, 4.1 km from South Main
9.2 out of 10, Wonderful, (1000)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is 3.096.824 ₫
4.150.745 ₫ total
includes taxes & fees
7 Dec - 8 Dec
InterContinental Houston by IHG
Exterior
Holiday Inn Express & Suites Houston – Downtown North by IHG

Holiday Inn Express & Suites Houston – Downtown North by IHG

2.5 star property
Northside, 13.7 km from South Main
9.2 out of 10, Wonderful, (614)
"Nice staff and very clean "
United States
Luis
The price is 2.616.202 ₫
3.060.955 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express & Suites Houston – Downtown North by IHG
Premium bedding, desk, iron/ironing board, free WiFi
Haven Inn & Suites Downtown Houston

Haven Inn & Suites Downtown Houston

2.5 star property
North Houston, 18.8 km from South Main
9.4 out of 10, Exceptional, (1000)
"Very clean and safe, would stay again"
United States
Krimson
Haven Inn & Suites Downtown Houston
Exterior
Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

2.5 star property
18.4 km from South Main
8.8 out of 10, Excellent, (1001)
"Clean, quiet and will return "
United States
Lauren
The price is 2.510.710 ₫
2.950.837 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Houston - Memorial City Centre by IHG
Exterior
Hilton Americas-Houston

Hilton Americas-Houston

4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1594)
"Clean, great location and super convenient food options!"
United States
Valerie
The price is 3.882.106 ₫
4.603.778 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Hilton Americas-Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green showing city views, modern architecture and a high-rise building

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Jesse H. Jones Hall – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Menil Collection featuring interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow

10/10 Excellent
"It was centrally located to everything that we needed to get to."
Terrence 4-night trip
Posted 2 days ago
Heritage Place Houston Brookhollow

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.