South Main Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Houston

Downtown Houston

3 out of top 10 points of interest in this area
4/5(25 area reviews)

Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

Find hotels in Downtown Houston

Top hotels in South Main

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is 2.633.800 ₫ per night from 20 Apr to 21 Apr
2.633.800 ₫
3.081.547 ₫ total
20 Apr - 21 Apr
includes taxes & fees
7/10 Good! (1,295 reviews)
Bar was nice parking had plenty and rooms super clean

Reviewed on 15 Apr 2026

Wyndham Houston near NRG Park/Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
The price is 3.469.584 ₫ per night from 11 May to 12 May
3.469.584 ₫
4.087.857 ₫ total
11 May - 12 May
includes taxes & fees
8.4/10 Very Good! (3,820 reviews)
The rooms were fairly dingy and not all in the best repair

Reviewed on 17 Apr 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
The price is 2.528.448 ₫ per night from 27 Apr to 28 Apr
2.528.448 ₫
2.958.284 ₫ total
27 Apr - 28 Apr
includes taxes & fees
8.6/10 Excellent! (4,080 reviews)
Convenient and clean

Reviewed on 17 Apr 2026

Club Quarters Hotel Downtown, Houston
See all 6,699 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a South Main holiday package cost?
Get set to book, because a getaway to South Main starts from an enticing . When you combine your flights, hotels and more into a travel package, you'll walk away with the best bargains.
How do I get a cheap travel package to South Main?
You'll save tons of cash if you bundle your car rentals, hotels and flights into a South Main holiday package. Sometimes cheap means fewer options. But that's not the case with Expedia. We offer over 550 airlines and 1null000null000 hotels across the globe, which means you'll always have plenty of variety to choose from. Like to save even more? Add some interesting activities to your package deal to unlock even bigger bargains! After all, travel is about more than just getting to your destination.
Where should I stay in South Main?
Book a hotel within walking distance of Houston Zoo, one of this neighbourhood's most popular attractions. It's the perfect spot if you're an eager sightseer.
What are the top hotels in South Main?
Get your trip off to a fantastic start by booking a stay at Travellers Dream 1bd 1 Bath Getaway. It's one of most popular hotels in South Main. Another welcoming option is Luxury King And Queen 1bedroom Suite | Nrg Stadium | Medical Ctr | Galleria | Downtown.
How far in advance should I book my South Main holiday?
It all depends on the air carrier, but you can usually browse through international airfares on Expedia nearly a year in advance. While it's a good idea to book ahead of time, lucky customers occasionally find a cheaper seat just weeks before the date of departure.
What does an Expedia South Main travel package include?
Flights, car rentals and hotels — we bring you all the best deals. All you have to do is figure out your favourite combination. Once you've made your booking, you can add on the exciting stuff like sightseeing activities. Our travel packages make it easy to customize an unforgettable South Main holiday.
What should I know before booking a South Main travel package?
You can save big by bundling your hotels, airfares and rental cars. Once you've made your booking, you can add on things like sightseeing tours or experiences. Your next unforgettable adventure is only a couple of clicks away.
Can I choose my airline with a South Main Expedia holiday package?
You certainly can. Expedia has access to more than 550 airline partners around the world, so fly with the carrier that best suits your needs.
If I'm not able to travel, can I cancel my South Main holiday package?
It's hard to predict what the future holds, so it's comforting to know that you can change or cancel your South Main holiday package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Visit our Customer Service Portal to learn more.

Popular places to visit

The George R. Brown Convention Center

George R. Brown Convention Center

During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.

George R. Brown Convention Center
Houston_MinuteMaidPark_6034772_1

Daikin Park

Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art galleries and great live music in this vibrant area.

Daikin Park
Houston, Texas Reflections

MD Anderson Cancer Center

If MD Anderson Cancer Center is what brings you to town, hopefully you'll have a chance to explore more of Houston.

MD Anderson Cancer Center