South Main Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Houston

Downtown Houston

4 out of top 10 points of interest in this area
4/5(25 area reviews)

Gourmet restaurants acclaimed theatres and top sights from Downtown Aquarium to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

Find hotels in Downtown Houston

Top hotels in South Main

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
The price is 2.655.464 ₫ per night from 5 Jul to 6 Jul
2.655.464 ₫
3.106.903 ₫ total
5 Jul - 6 Jul
includes taxes & fees
8.6/10 Excellent! (4,243 reviews)
"Nice place and close to parking garages"

Reviewed on 17 Jun 2026

Club Quarters Hotel Downtown, Houston
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
The price is 4.713.871 ₫ per night from 18 Jul to 19 Jul
4.713.871 ₫
5.515.230 ₫ total
18 Jul - 19 Jul
includes taxes & fees
9/10 Wonderful! (3,908 reviews)
"Clean rooms very close to MD Anderson and had no problems driving or walking to and from the hospital. Very trendy hotel and easy to get oort of traffic."

Reviewed on 17 Jun 2026

Blossom Hotel Houston, Curio Collection by Hilton
Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
The price is 2.819.193 ₫ per night from 6 Jul to 7 Jul
2.819.193 ₫
3.298.535 ₫ total
6 Jul - 7 Jul
includes taxes & fees
8/10 Very Good! (109 reviews)
"I didn't like that I had to pay for parking, and breakfast was not included since It was not great , barely decent."

Reviewed on 17 Jun 2026

Grand Tuscany Hotel
See all 7,145 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a South Main holiday package cost?
Get set to book, because a getaway to South Main starts from an enticing . When you combine your flights, hotels and more into a travel package, you'll walk away with the best bargains.
How do I get a cheap travel package to South Main?
You'll save tons of cash if you bundle your car rentals, hotels and flights into a South Main holiday package. Sometimes cheap means fewer options. But that's not the case with Expedia. We offer over 550 airlines and 1null000null000 hotels across the globe, which means you'll always have plenty of variety to choose from. Like to save even more? Add some interesting activities to your package deal to unlock even bigger bargains! After all, travel is about more than just getting to your destination.
Where should I stay in South Main?
Book a hotel within walking distance of Houston Zoo, one of this neighbourhood's most popular attractions. It's the perfect spot if you're an eager sightseer.
What are the top hotels in South Main?
Get your trip off to a fantastic start by booking a stay at Travellers Dream 1bd 1 Bath Getaway. It's one of most popular hotels in South Main. Another welcoming option is Luxury King And Queen 1bedroom Suite | Nrg Stadium | Medical Ctr | Galleria | Downtown.
How far in advance should I book my South Main holiday?
It all depends on the air carrier, but you can usually browse through international airfares on Expedia nearly a year in advance. While it's a good idea to book ahead of time, lucky customers occasionally find a cheaper seat just weeks before the date of departure.
What does an Expedia South Main travel package include?
Flights, car rentals and hotels — we bring you all the best deals. All you have to do is figure out your favourite combination. Once you've made your booking, you can add on the exciting stuff like sightseeing activities. Our travel packages make it easy to customize an unforgettable South Main holiday.
What should I know before booking a South Main travel package?
You can save big by bundling your hotels, airfares and rental cars. Once you've made your booking, you can add on things like sightseeing tours or experiences. Your next unforgettable adventure is only a couple of clicks away.
Can I choose my airline with a South Main Expedia holiday package?
You certainly can. Expedia has access to more than 550 airline partners around the world, so fly with the carrier that best suits your needs.
If I'm not able to travel, can I cancel my South Main holiday package?
It's hard to predict what the future holds, so it's comforting to know that you can change or cancel your South Main holiday package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Visit our Customer Service Portal to learn more.