
South San Diego Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by Elizabeth Bagnas
Where to stay in South San Diego
Find the best South San Diego areas and neighborhoods for the activities you enjoy most. Learn more about South San Diego

Otay Mesa West
Even though there aren't top sights in Otay Mesa West, you can explore the larger area and take in top sights like San Ysidro Border Crossing. Jump on the metro at Iris Avenue Trolley Station to see more of the city.
Top hotels in South San Diego

Holiday Inn Express San Diego South - Chula Vista by IHG
632 E Street Chula Vista CA
Fully refundableReserve now, pay when you stay
The price is 4.318.288 ₫ per night from 28 Jun to 29 Jun
4.318.288 ₫
4.750.248 ₫ total
28 Jun - 29 Jun
includes taxes & fees
9.4/10 Exceptional! (1,246 reviews)
"Nice experience and staff was amazing!"
Reviewed on 18 Jun 2026

Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is 6.817.657 ₫ per night from 1 Jul to 2 Jul
6.817.657 ₫
9.339.137 ₫ total
1 Jul - 2 Jul
includes taxes & fees
9/10 Wonderful! (2,803 reviews)
"Very friendly staff, very nice & clean rooms. The roof top bar service excellent, and spectacular view. How do you recommend."
Reviewed on 17 Jun 2026

The Sofia Hotel
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The price is 2.947.123 ₫ per night from 29 Jun to 30 Jun
2.947.123 ₫
4.152.980 ₫ total
29 Jun - 30 Jun
includes taxes & fees
8.6/10 Excellent! (2,252 reviews)
"The hotel adds a vague “Guest Services” fee of $24 per night that is in the fine print of the advertised room rate. This brought the actual cost to about $215/night at checkout. If these mandatory fees were included upfront, some budget-conscious travelers might filter the property out during their ..."
Reviewed on 18 Jun 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.





