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Our top choices for Southern Illinois hotels

Spa

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Candy

3.296.528 ₫ total

includes taxes & fees

9 Aug - 10 Aug

2. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Anne-Marie

2.637.741 ₫ total

includes taxes & fees

21 Aug - 22 Aug

3. Best Western Delta Inn

Effingham

Roger

2.980.641 ₫ total

includes taxes & fees

17 Aug - 18 Aug

4. Holiday Inn Express & Suites Vandalia by IHG

Vandalia

Rebecca

2.946.360 ₫ total

includes taxes & fees

23 Aug - 24 Aug

5. Cobblestone Inn & Suites - Altamont

Altamont

William

2.812.811 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Desk, laptop workspace, blackout curtains, iron/ironing board

6. Baymont by Wyndham Effingham

Effingham

Amy

2.136.756 ₫ total

includes taxes & fees

18 Aug - 19 Aug

7. Best Western Plus Parkside Inn & Suites

Olney

Brenda

3.698.735 ₫ total

includes taxes & fees

11 Aug - 12 Aug

In-room safe, desk, iron/ironing board, cots/infant beds

8. Quality Inn & Suites Vandalia near I-70 and Hwy 51

Vandalia

John

1.832.389 ₫ total

includes taxes & fees

2 Aug - 3 Aug

9. Suite Dreams Hotel

Mattoon

Judd

2.799.390 ₫ total

includes taxes & fees

6 Aug - 7 Aug

10. Holiday Inn Effingham by IHG

Effingham

Parry

2.807.311 ₫ total

includes taxes & fees

20 Aug - 21 Aug

11. La Quinta Inn & Suites by Wyndham Effingham

Effingham

michael

3.211.453 ₫ total

includes taxes & fees

9 Aug - 10 Aug

12. Super 8 by Wyndham Troy IL/St. Louis Area

Troy

Donta

2.102.716 ₫ total

includes taxes & fees

30 Jul - 31 Jul

13. Best Western Marion Hotel

Marion

Lauren

2.824.116 ₫ total

includes taxes & fees

19 Aug - 20 Aug

14. Holiday Inn Express & Suites Mattoon by IHG

Mattoon

Tyler

2.696.967 ₫ total

includes taxes & fees

13 Aug - 14 Aug

15. Drury Inn & Suites Marion

Marion

Claudia

3.159.410 ₫ total

includes taxes & fees

9 Aug - 10 Aug

16. Ramada by Wyndham Vandalia

Vandalia

Samantha

2.295.885 ₫ total

includes taxes & fees

2 Aug - 3 Aug

17. Best Western Plus MidAmerica Hotel

Mascoutah

Craig

3.286.400 ₫ total

includes taxes & fees

26 Aug - 27 Aug

Iron/ironing board, free WiFi, bed sheets

18. Quality Inn & Suites Metropolis I-24

Metropolis

Howard

1.993.029 ₫ total

includes taxes & fees

11 Aug - 12 Aug

19. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Lori

2.337.835 ₫ total

includes taxes & fees

30 Jul - 31 Jul

20. The Principal Hotel

Columbia

Bounma

3.294.638 ₫ total

includes taxes & fees

11 Aug - 12 Aug

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Holiday Rentals in Southern Illinois

Cottage

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Holiday Home

Villa, 4 Bedrooms | Private kitchen | Coffee/tea maker, fridge, oven

Belleville Beauty - Luxury Stay For Work Or Stay For Play Either Way This Is The Perfect Property For You! 4 Bedroom Residence by RedAwning

Belleville

"Home was nice it was older but redone. Definitely a diy job and it was noticeable. Perfect for what we needed. Every comfortable. Area was okay. Not the nicest area but also not the worst. Very good for the price. Beds were comfortable and showers were nice and hot. No coffee but there was a coffee it and Keurig. "

Cottage

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

Apartment

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

Country Home Near EIU & Lake Charleston!

Charleston

"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...

Cottage

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

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Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

You can take time to visit Garden of the Gods Recreation Area during your travels to Equality. Wander the parks and riverfront while you're in the area.

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Learn more about Southern Illinois

Experience the family-friendly area of Southern Illinois—live music, an opera house and sights from Jefferson County Fairgrounds to King City Square Shopping Center.

See all hotels in Southern Illinois

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Top Southern Illinois Hotel Reviews

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent

"Awesome all around."

Ramada by Wyndham Effingham

8/10 Good

"The room was clean. The staff was excellent. I like the location. It diminishes the traffic noise. Nice hiking trail nearby. I love the fact that they are dog friendly. Only a couple of minor issues: The thermostat on the A/C unit did not work. No matter how high I set the temperature, the unit never shut off. No problem. I just turned it on and off manually. The tub could be replaced. It was functional, but it did not look too nice. Not a problem for me, but some guests might not like that."