Southern Illinois Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by Southernmost Illinois Tourism Bureau
Where to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Eastport
While visiting Eastport, you might make a stop by sights like Gateway Conference Center and Splash City Family Waterpark.
Top hotels in Southern Illinois
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
The price is 2.915.929 ₫ per night from 23 Jan to 24 Jan
2.915.929 ₫
3.288.641 ₫ total
23 Jan - 24 Jan
includes taxes & fees
9.6/10 Exceptional! (1,621 reviews)
Room was very clean, staff is very friendly and the food and drinks amenities were really nice.
Reviewed on 11 Jan 2026
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
The price is 1.116.560 ₫ per night from 25 Jan to 26 Jan
1.116.560 ₫
1.283.820 ₫ total
25 Jan - 26 Jan
includes taxes & fees
7/10 Good! (1,006 reviews)
The staff was very friendly and the room looked fantastic
Reviewed on 6 Jan 2026
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
The price is 2.469.305 ₫ per night from 25 Jan to 26 Jan
2.469.305 ₫
2.789.823 ₫ total
25 Jan - 26 Jan
includes taxes & fees
9/10 Wonderful! (1,000 reviews)
Clean room and great amenities!
Reviewed on 13 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Southern Illinois University
Enjoy the student vibe when you visit Southern Illinois University during your trip to Carbondale. Visit the shops and top-notch restaurants in this family-friendly area.
Garden of the Gods Recreation Area
You can take time to visit Garden of the Gods Recreation Area during your travels to Equality. Wander the parks and riverfront while you're in the area.
Harrah's Metropolis
Why not roll the dice with a visit to Harrah's Metropolis during your visit to Metropolis? Visit the casinos and top-notch restaurants in this family-friendly area.
