Our top choices for Upstate South Carolina hotels

Hampton Inn Gaffney

Gaffney

Anthony

3.278.210 ₫ total

includes taxes & fees

5 Apr - 6 Apr

Holiday Inn Express Gaffney by IHG

Gaffney

Janice

2.428.727 ₫ total

includes taxes & fees

15 Mar - 16 Mar

The Inn at Patrick Square

Clemson

Joyce

4.626.509 ₫ total

includes taxes & fees

10 Mar - 11 Mar

Hampton Inn Greer Greenville, SC

Greer

Tyler

4.000.256 ₫ total

includes taxes & fees

3 Apr - 4 Apr

Inn on the Square, an Ascend Collection Hotel

Uptown Greenwood

michelle

3.143.697 ₫ total

includes taxes & fees

29 Mar - 30 Mar

Clemson University's James F. Martin Inn

Clemson

Paige

4.335.533 ₫ total

includes taxes & fees

12 Mar - 13 Mar

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Annisha

3.088.272 ₫ total

includes taxes & fees

5 Apr - 6 Apr

Best Western Plus Clemson Hotel & Conference Center

Clemson

Tina

2.770.088 ₫ total

includes taxes & fees

10 Mar - 11 Mar

Comfort Inn & Suites Greer - Greenville

Greer

pamela

2.473.260 ₫ total

includes taxes & fees

22 Mar - 23 Mar

Hilton Garden Inn Anderson

Anderson

Sadie

2.890.259 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Hampton Inn Easley

Easley

Thomas

4.032.337 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Lori

2.997.046 ₫ total

includes taxes & fees

22 Mar - 23 Mar

Quality Inn Seneca Clemson Area US-123

Downtown

Susan

2.404.978 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Four Points by Sheraton Spartanburg

Spartanburg

Ashley

3.462.607 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Lakeside Lodge Clemson

Seneca

Jeffrey

3.547.016 ₫ total

includes taxes & fees

10 Mar - 11 Mar

Tru by Hilton Spartanburg

Spartanburg

Ronald

2.666.209 ₫ total

includes taxes & fees

15 Mar - 16 Mar

Spartanburg Marriott

Spartanburg

Alicia

3.433.511 ₫ total

includes taxes & fees

22 Mar - 23 Mar

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

DENNIS

2.830.849 ₫ total

includes taxes & fees

12 Mar - 13 Mar

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Tammy

2.399.105 ₫ total

includes taxes & fees

15 Mar - 16 Mar

3 restaurants, breakfast, dinner served; Modern European cuisine

AC Hotel by Marriott Spartanburg

Spartanburg

Frank

4.626.509 ₫ total

includes taxes & fees

22 Mar - 23 Mar

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Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Aparthotel

Full-sized fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Room was very clean and welcoming. The only staff we met was Mark, and he was absolutely wonderful and friendly. "

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Spotless wonderful stay"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Lake "

Cottage

Stunning Lakefront Retreat w/ Dock Access!

Greenwood

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

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Stay near popular Southeastern United States attractions

Clemson University

4.7/5 (738 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Nice little church with a beautiful Mountain view

Fred W. Symmes Chapel

4.8/5 (13 reviews)

You can find out about the history of Cleveland with a visit to Fred W. Symmes Chapel. Wander the lakeside and forests in this relaxing area.

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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

See all hotels in Upstate South Carolina

It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls

#Waterfall

Top Upstate South Carolina Hotel Reviews

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

8/10 Good

"AC unit was very loud, so did not sleep much"

Hyatt Place Greenville Downtown

2/10 Terrible

"Blood stain on bedspread. No housekeeping to change beds. We had to remove blood stain spread ourselves. Only gave a top sheet and blanket to make our own bed.Daughter was locked in restroom. She did not lock it herself. We had to call front desk to get her out. No maintenance was available to fix door from locking again."

Urban Boutique Hotel, BW Signature Collection

6/10 Okay

"This is urban, for sure - right next to a gas station and in a run down looking neighborhood. It’s not a hotel - it’s a motel. We were awakened at 3 AM by a huge domestic disturbance in the room next to us. Shouting, banging, violent sounds - the police came - twice. "

More cheap stays in Upstate South Carolina

Sleep Inn Spartanburg Southwest

501 South Blackstock Rd Spartanburg SC

1.612.161 ₫

1.789.500 ₫ total

1 Apr - 2 Apr

includes taxes & fees

6/10 (565 reviews)

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Our top choices for Upstate South Carolina hotels

Hampton Inn Gaffney

Holiday Inn Express Gaffney by IHG

The Inn at Patrick Square

Hampton Inn Greer Greenville, SC

Inn on the Square, an Ascend Collection Hotel

Clemson University's James F. Martin Inn

Embassy Suites Greenville Golf Resort & Conference Center

Best Western Plus Clemson Hotel & Conference Center

Comfort Inn & Suites Greer - Greenville

Hilton Garden Inn Anderson

Hampton Inn Easley

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Quality Inn Seneca Clemson Area US-123

Four Points by Sheraton Spartanburg

Lakeside Lodge Clemson

Tru by Hilton Spartanburg

Spartanburg Marriott

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Best Western Plus Greenville I-385 Inn & Suites

AC Hotel by Marriott Spartanburg

Holiday Rentals in Upstate South Carolina

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Stay near popular Southeastern United States attractions

Clemson University

Fred W. Symmes Chapel

Learn more about Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

More cheap stays in Upstate South Carolina

Sleep Inn Spartanburg Southwest

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