Upstate South Carolina Holidays

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville which includes a bridge, a garden and autumn leaves

Greenville Downtown

3 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Top hotels in Upstate South Carolina

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
The price is 2.545.949 ₫ per night from 28 Dec to 29 Dec
2.545.949 ₫
2.876.924 ₫ total
28 Dec - 29 Dec
includes taxes & fees
8.2/10 Very Good! (1,001 reviews)
Amazing staff and clean room

Reviewed on 7 Dec 2025

Hilton Greenville
Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
950 South Main Street Greenville SC
Fully refundableReserve now, pay when you stay
The price is 3.214.189 ₫ per night from 21 Dec to 22 Dec
3.214.189 ₫
3.632.032 ₫ total
21 Dec - 22 Dec
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
All of the above, one of the cleanest, luxurious hotel with many amenities I have stayed in , in along time

Reviewed on 11 Dec 2025

Homewood Suites by Hilton Greenville Downtown
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
The price is 3.551.445 ₫ per night from 23 Dec to 24 Dec
3.551.445 ₫
4.023.789 ₫ total
23 Dec - 24 Dec
includes taxes & fees
8.6/10 Excellent! (1,004 reviews)
Excellent

Reviewed on 12 Dec 2025

Hyatt Regency Greenville
See all 2,954 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Falls Park on the Reedy

Falls Park on the Reedy

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theatre scene or attend a sporting event in this family-friendly area.

Falls Park on the Reedy
Memorial Stadium

Memorial Stadium

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theatre scene or attend a football match.

Memorial Stadium
Fred W. Symmes Chapel

Fred W. Symmes Chapel

You can find out about the history of Cleveland with a visit to Fred W. Symmes Chapel. Wander the lakeside and forests in this relaxing area.

Fred W. Symmes Chapel