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9 Dec - 10 Dec
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Our top choices for Uptown hotels

Lobby
Hampton Inn Hilton Head

Hampton Inn Hilton Head

2.5 star property
25 km from Uptown
8.4 out of 10, Very good, (1004)
"Nice staff, clean room, tasty food "
United States
William
The price is 2.404.214 ₫
2.644.634 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Hilton Head
Exterior
Best Western Sea Island Inn

Best Western Sea Island Inn

2.5 star property
The Bluff, 0.9 km from Uptown
9.4 out of 10, Exceptional, (1003)
"Perfect spot!"
United States
Tricia
The price is 3.677.375 ₫
4.045.113 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Best Western Sea Island Inn
Snack bar
Tru by Hilton Beaufort, SC

Tru by Hilton Beaufort, SC

2.5 star property
4.6 km from Uptown
9.0 out of 10, Wonderful, (704)
"Awesome stay!!!"
United States
Michael
The price is 2.509.662 ₫
2.760.629 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Tru by Hilton Beaufort, SC
Premium bedding, down duvets, memory-foam beds, in-room safe
Best Western Point South

Best Western Point South

2.5 star property
28.4 km from Uptown
8.0 out of 10, Very good, (1004)
"Room was clean Staff was friendly "
United States
Brian
The price is 2.346.218 ₫
2.651.225 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Best Western Point South
Premium bedding, individually decorated, individually furnished
Beaufort Inn

Beaufort Inn

3.5 star property
Downtown Beaufort, 0.9 km from Uptown
9.0 out of 10, Wonderful, (1003)
"If you are looking for a unique place to stay, this would be it. Staff was great and the rooms were clean."
United States
Samantha
Beaufort Inn
Exterior
Hilton Garden Inn Hilton Head

Hilton Garden Inn Hilton Head

3.0 star property
25.8 km from Uptown
8.6 out of 10, Excellent, (1007)
"Wonderful stay!"
United States
Ashley
The price is 2.415.550 ₫
2.657.104 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hilton Garden Inn Hilton Head
Exterior
Hilton Garden Inn Beaufort

Hilton Garden Inn Beaufort

3.0 star property
1.4 km from Uptown
8.4 out of 10, Very good, (1004)
"Good hotel"
United States
joshua
The price is 2.354.743 ₫
2.590.217 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton Garden Inn Beaufort
Miscellaneous
Super 8 by Wyndham Port Royal/Beaufort

Super 8 by Wyndham Port Royal/Beaufort

2.0 star property
4.6 km from Uptown
6.0 out of 10, (905)
"The room could have been a little cleaner but all and all it was Great! "
United States
Gina
The price is 1.613.354 ₫
1.774.690 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Port Royal/Beaufort
Lobby sitting area
Hampton Inn Yemassee/Point South

Hampton Inn Yemassee/Point South

2.5 star property
28.8 km from Uptown
8.8 out of 10, Excellent, (770)
"Great front desk service and good food"
United States
Stephen
The price is 3.437.078 ₫
3.883.897 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hampton Inn Yemassee/Point South
Exterior
Rhett House Inn

Rhett House Inn

4.0 star property
The Bluff, 0.7 km from Uptown
9.2 out of 10, Wonderful, (641)
"Quaint. Dining room and breakfast excellent"
United States
Deborah
The price is 3.840.921 ₫
5.069.916 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Rhett House Inn
Reception
Hampton Inn Beaufort

Hampton Inn Beaufort

2.5 star property
2.5 km from Uptown
8.4 out of 10, Very good, (1001)
"Friendly staff, modern renovation inside, the room was very comfortable and the coffee selection was fantastic."
United States
Jackie
The price is 2.509.758 ₫
2.760.734 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Beaufort
Lobby
Days Inn by Wyndham Ridgeland South Carolina

Days Inn by Wyndham Ridgeland South Carolina

2.0 star property
28.4 km from Uptown
5.8 out of 10, (612)
"Parking was fine, staff was good, breakfast was okay, room was clean."
United States
Raymond
The price is 1.497.418 ₫
1.692.084 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Days Inn by Wyndham Ridgeland South Carolina
Terrace/patio
Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

3.0 star property
2 km from Uptown
8.2 out of 10, Very good, (1003)
"great location "
United States
Huntley
The price is 2.346.218 ₫
2.580.839 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG
Exterior
607 Bay Inn Downtown Beaufort

607 Bay Inn Downtown Beaufort

2.5 star property
The Old Point, 1.1 km from Uptown
9.8 out of 10, Exceptional, (89)
"Great Inn! Location, view, cleanliness, friendly staff!"
United States
Nicole
607 Bay Inn Downtown Beaufort
Lobby lounge
Comfort Suites near MCAS Beaufort

Comfort Suites near MCAS Beaufort

2.5 star property
3.8 km from Uptown
7.4 out of 10, Good, (1004)
"I felt safe and the room was very clean. I received great customer service "
United States
Tonya
The price is 2.218.362 ₫
2.585.189 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites near MCAS Beaufort
Pillow-top beds, desk, laptop workspace, soundproofing
Baymont by Wyndham Ridgeland I-95

Baymont by Wyndham Ridgeland I-95

2.5 star property
28.2 km from Uptown
6.8 out of 10, (570)
"Everything was great"
United States
Sandra
The price is 1.706.021 ₫
1.957.591 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Baymont by Wyndham Ridgeland I-95
2 bars/lounges, poolside bar
The Westin Hilton Head Island Resort & Spa

The Westin Hilton Head Island Resort & Spa

4.0 star property
25.6 km from Uptown
8.4 out of 10, Very good, (1003)
"Wonderful hotel, great staff, beautiful location. You can’t ask for more. "
United States
Joseph
The price is 3.338.747 ₫
4.873.410 ₫ total
includes taxes & fees
23 Dec - 24 Dec
The Westin Hilton Head Island Resort & Spa
Lobby
Econo Lodge

Econo Lodge

2.0 star property
28.6 km from Uptown
6.8 out of 10, (120)
"Decent place to stay. "
United States
Gregory
The price is 1.344.198 ₫
1.518.944 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Econo Lodge
Free daily on-the-go breakfast
Howard Johnson by Wyndham Beaufort/Parris Island

Howard Johnson by Wyndham Beaufort/Parris Island

2.0 star property
4.7 km from Uptown
6.0 out of 10, (891)
"Room was good "
United States
INDIRA
The price is 2.078.644 ₫
2.286.508 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Howard Johnson by Wyndham Beaufort/Parris Island
Lobby
Quality Inn & Suites Ridgeland

Quality Inn & Suites Ridgeland

2.5 star property
28.3 km from Uptown
6.6 out of 10, (605)
"Os a good car for drive "
United States
Rosswein
The price is 1.811.597 ₫
2.152.552 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn & Suites Ridgeland
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Uptown

Find the best Uptown areas for the activities you enjoy most.

Historic District

While visiting Historic District, you might make a stop by sights like Bay Street and Henry C. Chambers Waterfront Park.

Downtown Beaufort

While visiting Downtown Beaufort, you might make a stop by sights like Henry C. Chambers Waterfront Park and Bay Street.

Habersham

If you're looking for some top things to see and do in Habersham and surrounding area, you can visit Ocean Creek and Highway 21 Drive-In Theater.

The Old Commons

If you're looking for some top things to see and do in The Old Commons and surrounding area, you can visit Bay Street and Henry C. Chambers Waterfront Park.

Northwest Quadrant

While there might not be top attractions in Northwest Quadrant, you can explore the larger area and discover places like Beaufort National Cemetery and Henry C. Chambers Waterfront Park.

Top Uptown Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Uptown?
Travellers will be sure to enjoy their time in Beaufort's Uptown neighbourhood.
How many hotels will I be able to find in Uptown?
If you're searching for places to stay in Beaufort, choose from one of Expedia's 12 hotels and other accommodation options in Uptown.
If I need to cancel my hotel reservation in Uptown, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the top deals on offer in Uptown.
What is there to do in this Beaufort neighbourhood?
A few places to visit in the area around Uptown include Beaufort National Cemetery, USCB Center for the Arts and St. Helena's Episcopal Church. Beaufort Museum and Henry C. Chambers Waterfront Park are also worth a visit when you're out sightseeing in Beaufort.