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9 Dec - 10 Dec
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10 Dec - 11 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Uptown hotels

Rooftop terrace
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3.0 star property
17.8 km from Uptown
9.4 out of 10, Exceptional, (3279)
"Our stay was very enjoyable. Location was great and kids loved the indoor pool!"
United States
Christy
The price is 3.558.606 ₫
4.161.042 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Drury Plaza Hotel St. Louis at the Arch
Indoor pool
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3.0 star property
19.5 km from Uptown
9.4 out of 10, Exceptional, (1296)
"Great location and staff are friendly. "
United States
GARY
The price is 3.136.814 ₫
3.730.486 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Drury Inn & Suites St. Louis Union Station
Lobby
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4.0 star property
17.7 km from Uptown
8.4 out of 10, Very good, (4018)
"Loved our stay. Great location and awesome view from room "
United States
Phillip
The price is 2.491.209 ₫
2.937.858 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hyatt Regency St. Louis at The Arch
Exterior
Moonrise Hotel

Moonrise Hotel

4.0 star property
26.8 km from Uptown
9.0 out of 10, Wonderful, (1922)
"Great service, unique hotel. Would absolutely stay again!"
United States
Michael
The price is 3.168.976 ₫
3.768.975 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Moonrise Hotel
3 bars/lounges, rooftop bar
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4.0 star property
18 km from Uptown
7.6 out of 10, Good, (1067)
"Clean room, this hotel is great for young people, night activity, 360 rooftop bar always crowded but pretty."
United States
Joan
The price is 3.869.414 ₫
4.601.856 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Hilton St. Louis at the Ballpark
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

4.0 star property
17.8 km from Uptown
8.8 out of 10, Excellent, (1241)
"Great hospitality"
United States
Alejandro
The price is 2.826.006 ₫
3.360.941 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Embassy Suites by Hilton St. Louis Downtown
Lobby
The Great Rivers, an Ascend Collection Hotel

The Great Rivers, an Ascend Collection Hotel

3.0 star property
29 km from Uptown
7.8 out of 10, Good, (758)
"The hotel is being remodeled, so it's hard to give it a fair review."
United States
Stephen
The price is 2.218.099 ₫
2.528.190 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
The Great Rivers, an Ascend Collection Hotel
Exterior
Marriott St. Louis Grand

Marriott St. Louis Grand

4.0 star property
17.9 km from Uptown
8.2 out of 10, Very good, (1007)
"Everything was excellent "
United States
Josh
The price is 3.347.974 ₫
3.981.712 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Marriott St. Louis Grand
Terrace/patio
The Cheshire

The Cheshire

4.0 star property
27.7 km from Uptown
8.6 out of 10, Excellent, (1003)
"Excellent place to stay. "
United States
Todd
The price is 3.031.653 ₫
3.599.723 ₫ total
includes taxes & fees
29 Dec - 30 Dec
The Cheshire
Interior
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 star property
18.8 km from Uptown
9.0 out of 10, Wonderful, (1489)
"Room was perfect and parking was a breeze. We really enjoyed the art was wonderful. "
United States
London
The price is 3.338.874 ₫
4.035.927 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
21C Museum Hotel St Louis
Suite, 1 Bedroom, City View | Living room | Smart TV, Netflix
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

3.0 star property
18 km from Uptown
9.0 out of 10, Wonderful, (1003)
"Was a great stay. "
United States
Lorilyn
The price is 2.666.516 ₫
3.171.261 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Courtyard by Marriott St. Louis Downtown/Convention Center
Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4.0 star property
17.9 km from Uptown
8.8 out of 10, Excellent, (1145)
"So pleased with my stay would definitely recommend! Affordable and exclusive, staff ensured my stay was immaculate!"
United States
Meli
The price is 2.662.663 ₫
3.166.679 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Exterior
The Principal Hotel

The Principal Hotel

3.5 star property
30.7 km from Uptown
9.8 out of 10, Exceptional, (188)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is 2.973.897 ₫
3.300.522 ₫ total
includes taxes & fees
10 Dec - 11 Dec
The Principal Hotel
Breakfast, lunch and dinner served
Live by Loews - St.Louis

Live by Loews - St.Louis

4.0 star property
18.3 km from Uptown
9.4 out of 10, Exceptional, (1101)
"Great staff"
United States
Phillip
The price is 3.927.938 ₫
4.671.457 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Live by Loews - St.Louis
Terrace/patio
The West End

The West End

2.0 star property
22.6 km from Uptown
8.4 out of 10, Very good, (403)
"Great stay!"
United States
Shaniqua
The price is 2.016.693 ₫
2.858.976 ₫ total
includes taxes & fees
10 Dec - 11 Dec
The West End
Lobby sitting area
Forest Park Hotel by MDR

Forest Park Hotel by MDR

3.0 star property
26.3 km from Uptown
7.6 out of 10, Good, (1258)
"location attentive staff large king room"
United States
Stephen
Forest Park Hotel by MDR
Daily cooked-to-order breakfast for a fee
River City Casino & Hotel

River City Casino & Hotel

4.0 star property
28.2 km from Uptown
9.0 out of 10, Wonderful, (1449)
"Awesome place to stay!!"
United States
Kaitlyn
The price is 2.319.592 ₫
3.082.772 ₫ total
includes taxes & fees
15 Dec - 16 Dec
River City Casino & Hotel
Room, 2 Queen Beds | Hypo-allergenic bedding, free WiFi, bed sheets
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

2.5 star property
18.4 km from Uptown
7.6 out of 10, Good, (580)
"Everything great….very nice staff and security….delicious breakfast!!"
Canada
Derek
The price is 2.140.067 ₫
2.502.359 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Tru By Hilton St. Louis Downtown
Lobby
Comfort Inn Alton near I-255

Comfort Inn Alton near I-255

2.5 star property
29.1 km from Uptown
7.6 out of 10, Good, (498)
"Nice"
United States
Alexander
The price is 1.994.361 ₫
2.273.173 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn Alton near I-255
2 bars/lounges, rooftop bar
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3.0 star property
30.3 km from Uptown
9.2 out of 10, Wonderful, (222)
"Enjoyed my stay"
United States
Kingsley
The price is 3.216.164 ₫
3.754.486 ₫ total
includes taxes & fees
14 Dec - 15 Dec
AC Hotel St. Louis Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Uptown

Find the best Uptown areas for the activities you enjoy most.

Eastport

While visiting Eastport, you might make a stop by sights like Gateway Conference Center and Splash City Family Waterpark.

Mulberry Hills

Though Mulberry Hills may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Kruta Bakery.

Historic Downtown Collinsville

Though Historic Downtown Collinsville may not have many top sights, you can venture to the surrounding area to see attractions like World's Largest Catsup Bottle and Kruta Bakery.

Top Uptown Hotel Reviews

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Frequently asked questions

What is Uptown like?
Travellers to the Uptown neighbourhood in Collinsville will be sure to enjoy their stay. Are you looking for Uptown travel tips? Make sure that you visit Kruta Bakery and World's Largest Catsup Bottle while you're in the neighbourhood.
If I need to cancel my hotel reservation in Uptown, will I receive a refund?
Yes! Most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then use the filter option "fully refundable" to get the top deals on offer in Uptown.
What is there to do in this Collinsville neighbourhood?
A few attractions you might want to check out while you're in Uptown are Kruta Bakery and World's Largest Catsup Bottle. While you're out sightseeing, Gateway Conference Center and Gateway Fun Park are a couple of additional sights to visit in Collinsville.