Search Hotels in Uptown Greenville, Greenville

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
6 Dec - 7 Dec
Tomorrow
7 Dec - 8 Dec
Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Uptown Greenville, Greenville

Exterior
Hilton Garden INN Greenville University

Hilton Garden INN Greenville University

3.0 star property
Uptown Greenville
9.4 out of 10, Exceptional, (91)
"Great location. Rooftop bar and restaurant was nice and convenient."
United States
GEORGE
The price is 3.142.470 ₫
3.550.991 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton Garden INN Greenville University
Exterior
Holiday Inn Express Greenville by IHG

Holiday Inn Express Greenville by IHG

2.5 star property
2.3 km from Uptown Greenville
8.4 out of 10, Very good, (965)
"Great location and breakfast menu "
United States
Angela
The price is 2.504.485 ₫
2.830.068 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Greenville by IHG
Lobby
Comfort Inn & Suites Greenville near East Carolina University

Comfort Inn & Suites Greenville near East Carolina University

2.5 star property
4.8 km from Uptown Greenville
8.6 out of 10, Excellent, (387)
"Room was clean, the hotel staff gave excellent service everyone was friendly and accommodating. I will be staying at this hotel whenever I go to visit my family."
United States
Ericka
The price is 2.823.477 ₫
3.190.529 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Comfort Inn & Suites Greenville near East Carolina University
In-room safe, blackout curtains, free WiFi, bed sheets
Microtel Inn & Suites by Wyndham Greenville/University Medic

Microtel Inn & Suites by Wyndham Greenville/University Medic

2.0 star property
2.5 km from Uptown Greenville
7.2 out of 10, Good, (1003)
"Staff is nice and friendly "
United States
Tonya
The price is 1.613.416 ₫
1.823.160 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Microtel Inn & Suites by Wyndham Greenville/University Medic
Terrace/patio
Hampton Inn Greenville

Hampton Inn Greenville

2.5 star property
4.3 km from Uptown Greenville
9.0 out of 10, Wonderful, (566)
"Great stay."
United States
Mario
The price is 2.720.662 ₫
3.074.347 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Greenville
Exterior
Quality Inn Greenville near University

Quality Inn Greenville near University

2.5 star property
2 km from Uptown Greenville
7.4 out of 10, Good, (1001)
"The staff was very friendly "
United States
William
The price is 1.779.503 ₫
2.010.838 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Quality Inn Greenville near University
Exterior
Holiday Inn Greenville by IHG

Holiday Inn Greenville by IHG

3.0 star property
4.3 km from Uptown Greenville
8.8 out of 10, Excellent, (1000)
"Convenient location."
United States
GEORGE
The price is 2.778.660 ₫
3.139.887 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Greenville by IHG
Property amenity
Fairfield Inn & Suites by Marriott Greenville

Fairfield Inn & Suites by Marriott Greenville

2.5 star property
2.4 km from Uptown Greenville
8.6 out of 10, Excellent, (456)
"Convenient to Maynard children’s hospital. Friendly staff. Safe environment "
United States
DARLENE
The price is 3.110.834 ₫
3.515.242 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Fairfield Inn & Suites by Marriott Greenville
Exterior
Best Western Plus Suites-Greenville

Best Western Plus Suites-Greenville

2.5 star property
3.9 km from Uptown Greenville
9.0 out of 10, Wonderful, (1003)
"Very friendly staff and clean rooms "
United States
Craig
The price is 2.637.355 ₫
2.980.211 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Best Western Plus Suites-Greenville
Exterior
Homewood Suites By Hilton Greenville, NC

Homewood Suites By Hilton Greenville, NC

3.0 star property
2.4 km from Uptown Greenville
9.4 out of 10, Exceptional, (302)
"Room was perfect. We really appreciate our stay. "
United States
Carol
The price is 3.142.470 ₫
3.550.990 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Homewood Suites By Hilton Greenville, NC
Terrace/patio
Hilton Greenville

Hilton Greenville

4.0 star property
4.5 km from Uptown Greenville
8.8 out of 10, Excellent, (531)
"Hotel was very nice and clean. "
United States
Marcie
The price is 3.653.385 ₫
4.128.324 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Greenville
Property amenity
Candlewood Suites Greenville NC by IHG

Candlewood Suites Greenville NC by IHG

2.5 star property
4.7 km from Uptown Greenville
8.6 out of 10, Excellent, (585)
"I loved it will visit again "
United States
natalie
The price is 2.188.129 ₫
2.472.586 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Candlewood Suites Greenville NC by IHG
Suite, 1 Bedroom, Non Smoking, Jetted Tub | Down duvets, desk, iron/ironing board, free WiFi
Country Inn & Suites by Radisson, Greenville, NC

Country Inn & Suites by Radisson, Greenville, NC

3.0 star property
6.7 km from Uptown Greenville
7.6 out of 10, Good, (817)
"Great stay. clean and quiet."
United States
Lakeisha
The price is 2.332.335 ₫
2.661.901 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Country Inn & Suites by Radisson, Greenville, NC
Free daily continental breakfast
Baymont by Wyndham Greenville

Baymont by Wyndham Greenville

2.5 star property
5.5 km from Uptown Greenville
6.4 out of 10, (1001)
"If you're looking for a hotel for a one-night stay in a real emergency and you're not with your family, this could be a good option. It's very well located, but unfortunately, the dirty rooms and the general bad smell made us leave before our reserved time."
United States
Edwin
The price is 1.391.571 ₫
1.572.476 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Baymont by Wyndham Greenville
Exterior
Hampton Inn Washington

Hampton Inn Washington

2.5 star property
28 km from Uptown Greenville
8.2 out of 10, Very good, (661)
"Clean room friendly staff good breakfast "
United States
Gary
The price is 2.720.662 ₫
2.904.148 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Inn Washington
Free daily buffet breakfast
Quality Inn Washington NC

Quality Inn Washington NC

2.5 star property
28.5 km from Uptown Greenville
7.6 out of 10, Good, (328)
"Everything was great. Room, friendly staff, clean, smelt fresh. "
United States
Jessica
The price is 1.631.342 ₫
1.741.458 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Quality Inn Washington NC
Exterior
Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville

2.0 star property
2.3 km from Uptown Greenville
6.6 out of 10, (581)
"Staff was nice, room was clean. Had a great experience."
United States
Lashonda
The price is 1.635.824 ₫
1.848.480 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Super 8 by Wyndham Greenville
Property amenity
Fairfield Inn and Suites by Marriott Washington

Fairfield Inn and Suites by Marriott Washington

2.5 star property
27.1 km from Uptown Greenville
9.4 out of 10, Exceptional, (622)
"Great hotel. "
United States
Gwendolyn
The price is 3.110.834 ₫
3.507.466 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Fairfield Inn and Suites by Marriott Washington
Terrace/patio
Residence Inn by Marriott Greenville

Residence Inn by Marriott Greenville

3.0 star property
2.4 km from Uptown Greenville
8.8 out of 10, Excellent, (461)
"Malia at the front desk was extremely friendly and courteous, greeted us with a happy smile, and offered to help us in any way possible. The room was very nice, spacious, clean and comfortable. The shower was heavenly! The beds were comfortable and clean. The breakfast choices were many, with lots of good healthy choices. A very enjoyable stay all around! "
United States
Peter
The price is 2.926.293 ₫
3.306.711 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Residence Inn by Marriott Greenville
Reception
Courtyard Marriott Greenville

Courtyard Marriott Greenville

3.0 star property
Medical District, 2.8 km from Uptown Greenville
8.8 out of 10, Excellent, (879)
"Clean rooms, friendly staff and great location. Enjoyed our stay."
United States
Frederick
The price is 3.110.834 ₫
3.515.243 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Courtyard Marriott Greenville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Uptown Greenville

Find the best Uptown Greenville areas for the activities you enjoy most.

Medical District

If you're looking for some top things to see and do in Medical District and surrounding area, you can visit North Pines and Arlington Crossing.

Westhaven

Westhaven might not have many top sights, but 11 Galleria and Clark-LeClair Stadium are two attractions nearby that you can check out.

College View Historic District

If you're looking for some top things to see and do in College View Historic District and surrounding area, you can visit Williams Arena at Minges Coliseum and Dowdy–Ficklen Stadium.

Greenville Heights

If you're looking for some top things to see and do in Greenville Heights and surrounding area, you can visit North Pines and Town Common.

Top Uptown Greenville Hotel Reviews

Hilton Garden INN Greenville University

Hilton Garden INN Greenville University

10/10 Excellent
"Great location. Rooftop bar and restaurant was nice and convenient."
GEORGE 1-night trip
Posted 3 weeks ago
Hilton Garden INN Greenville University

Explore a world of travel with Expedia

Frequently asked questions

What is Uptown Greenville like?
Travellers will be sure to find plenty to entertain them in Greenville's Uptown Greenville neighbourhood. Are you looking for Uptown Greenville travel tips? Make sure that you visit Town Common and Greenville Museum of Art while you're in the neighbourhood.
If I need to cancel my hotel reservation in Uptown Greenville, will I receive a refund?
Yes, the majority of hotel room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view top deals in Uptown Greenville.
What is there to do around this Greenville neighbourhood?
A few attractions you might want to check out while you're in Uptown Greenville are Town Common and Greenville Museum of Art. Shepherd Memorial Library - Carver Branch and North Pines are also worth a visit when you're out sightseeing in Greenville.