Compare and book 4 Star hotels in Defiance, St. Louis

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Defiance 4 Star Hotels

This weekend
Next weekend

Our top choices for Defiance 4-star hotels

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,004 reviews)
"Staff at the hotel was exceptional! We try to stay here every time we're in St Louis. Food is outstanding as well!"
United States
Andrew
The price is 4.195.875 ₫
5.340.985 ₫ total
includes taxes & fees
25 May - 26 May
Ameristar Casino Resort and Spa

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
Frontenac
8.8 out of 10, Excellent, (1,006 reviews)
"Great place to stay "
United States
Tony
The price is 3.652.414 ₫
4.254.624 ₫ total
includes taxes & fees
31 May - 1 Jun
Hilton St. Louis Frontenac

DoubleTree by Hilton St. Louis - Westport

DoubleTree by Hilton St. Louis - Westport
4.0 star property
Maryland Heights
8.2 out of 10, Very good, (1,003 reviews)
"Room was really clean! And the gentlemen at the front desk was very helpful and friendly "
United States
Elizabeth
The price is 3.285.012 ₫
3.810.218 ₫ total
includes taxes & fees
10 May - 11 May
DoubleTree by Hilton St. Louis - Westport

DoubleTree by Hilton Hotel St. Louis - Chesterfield

DoubleTree by Hilton Hotel St. Louis - Chesterfield
4.0 star property
Chesterfield
8.6 out of 10, Excellent, (1,001 reviews)
"Clean room, friendly & helpful staff, cook prepared omelette breakfast was yumyum. Really enjoyed our stay!"
United States
David
The price is 3.786.039 ₫
4.391.352 ₫ total
includes taxes & fees
17 May - 18 May
DoubleTree by Hilton Hotel St. Louis - Chesterfield

The Inn at Elijah McLeans

The Inn at Elijah McLeans
4.0 star property
Washington
9.0 out of 10, Wonderful, (138 reviews)
"Lots of parking to include ADA spots. Very clean and comfortable room. Bar, lounge, and restaurant absolutely outstanding. "
United States
Richard
The price is 3.409.676 ₫
3.882.239 ₫ total
includes taxes & fees
10 May - 11 May
The Inn at Elijah McLeans

Landing Apartments - Eureka

Landing Apartments - Eureka
4.0 star property
Eureka
Landing Apartments - Eureka

'the Ruebling House': Bright, Modern, & Renovated!

'the Ruebling House': Bright, Modern, & Renovated!
4.0 star property
Defiance
'the Ruebling House': Bright, Modern, & Renovated!
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Defiance?
We can help you easily track down the perfect 4-star hotel for your holiday in Defiance. Use our filter tool to tailor your search by things like budget, conveniences and star rating and get access to awesome deals in a few clicks.

  • Search for the lowest price from 3.810.218 ₫

What's the difference between 5-star and 4-star hotels in Defiance?
Offering an inviting guest experience and upscale décor, 4-star hotels are a fabulous option for your Defiance break. These kinds of accommodation generally feature loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, gyms and restaurants. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Concierge assistance, complimentary toiletries and fine dining are typically included at these deluxe retreats.
Does Defiance have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to search for your dream hotel in Defiance where everything is taken care of, from your accommodation to your meals, activities and entertainment. We can also help you find standard 4-star stays in and around this leading destination.