Find hotels in Defiance, MO from 1.895.328 ₫

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Our top choices for Defiance hotels

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,003 reviews)
"Excellent place to stay!"
United States
Steven
The price is 1.949.290 ₫
2.226.577 ₫ total
includes taxes & fees
11 May - 12 May
Baymont by Wyndham Warrenton

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (976 reviews)
"Good breakfast. Parking Good. "
United States
Nicholas
The price is 2.182.277 ₫
2.464.881 ₫ total
includes taxes & fees
5 May - 6 May
Quality Inn Foristell

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.6 out of 10, Excellent, (102 reviews)
"Nice hotel with good staff."
United States
Michael
The price is 1.876.547 ₫
2.221.802 ₫ total
includes taxes & fees
5 May - 6 May
WoodSpring Suites St Peters-OFallon

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,256 reviews)
"Nice room, comfortable bed, good breakfast."
United States
John
The price is 2.352.273 ₫
2.716.776 ₫ total
includes taxes & fees
17 May - 18 May
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,005 reviews)
"This was one of our best stays ever nice hot breakfast. Clean room nice staff will stay again "
United States
Lavania
The price is 2.049.442 ₫
2.417.318 ₫ total
includes taxes & fees
5 May - 6 May
Sleep Inn & Suites O'Fallon MO - Technology Drive

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,203 reviews)
"This place is always clean and staff is always friendly. I stay here we very week for work "
United States
Steve
The price is 2.240.260 ₫
2.587.231 ₫ total
includes taxes & fees
5 May - 6 May
Wingate by Wyndham St. Louis/Fenton Route 66

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (646 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is 1.433.766 ₫
1.637.719 ₫ total
includes taxes & fees
11 May - 12 May
Super 8 by Wyndham Warrenton

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (680 reviews)
"Breakfast was good, as hotel breakfasts go. Room was clean, friendly and helpful staff. Had a good stay overall."
United States
Raymond
The price is 3.399.924 ₫
3.870.642 ₫ total
includes taxes & fees
5 May - 6 May
Best Western Plus Washington Hotel

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,004 reviews)
"Very nice, well maintained hotel with generous size rooms and great amenities. "
United States
William
The price is 2.925.252 ₫
3.422.194 ₫ total
includes taxes & fees
31 May - 1 Jun
Drury Inn & Suites Southwest St. Louis

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (277 reviews)
"Simply love it better than 4 star hotels"
United States
Srinivas
The price is 2.613.988 ₫
3.018.844 ₫ total
includes taxes & fees
7 May - 8 May
Best Western Plus Fenton

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,633 reviews)
"The hotel is really nice and close to good restaurants."
United States
Jackie
The price is 2.324.599 ₫
2.707.878 ₫ total
includes taxes & fees
25 May - 26 May
The Wildwood Hotel

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (375 reviews)
"Nice place! Will Use again"
United States
Jonathan
The price is 2.729.164 ₫
3.124.211 ₫ total
includes taxes & fees
6 May - 7 May
Quality Inn Near Six Flags St. Louis

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2,194 reviews)
"Accommodating staff, food availability, comfortable. "
United States
MaryMelissa
The price is 2.569.512 ₫
3.380.013 ₫ total
includes taxes & fees
1 Jun - 2 Jun
Hollywood Casino & Hotel St. Louis

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,001 reviews)
"Good spot and great location to visit with family "
United States
Ernest
The price is 2.061.303 ₫
2.431.307 ₫ total
includes taxes & fees
25 May - 26 May
Comfort Inn & Suites St. Louis - O'Fallon

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,006 reviews)
"Breakfast menu was adequate. Staff was pleasant and helpful, the room was very clean Did not use the hot tub."
United States
Rich
The price is 3.004.057 ₫
3.452.472 ₫ total
includes taxes & fees
17 May - 18 May
Hampton Inn St. Charles St. Peters

Cedar Creek

Cedar Creek
3.0 star property
New Haven
9.0 out of 10, Wonderful, (269 reviews)
"Nice quiet stay for nearby wedding. "
United States
joan
The price is 3.880.394 ₫
4.151.070 ₫ total
includes taxes & fees
5 May - 6 May
Cedar Creek

Super 8 by Wyndham Union

Super 8 by Wyndham Union
2.0 star property
Union
8.2 out of 10, Very good, (650 reviews)
"Pet friendly "
United States
Theresa
The price is 2.229.718 ₫
2.463.280 ₫ total
includes taxes & fees
11 May - 12 May
Super 8 by Wyndham Union

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (902 reviews)
"Very nice place to stay. Staff was super friendly. Clean, nice breakfast. "
United States
Patty
The price is 3.452.636 ₫
4.117.848 ₫ total
includes taxes & fees
10 May - 11 May
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,004 reviews)
"Great location and clean hotel!"
United States
Admir
The price is 2.898.896 ₫
3.332.281 ₫ total
includes taxes & fees
17 May - 18 May
Drury Inn & Suites St. Louis St. Peters

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1,068 reviews)
"Nice place comfortable and close to hospital and Dr appts "
United States
Teresa
The price is 2.329.870 ₫
2.702.370 ₫ total
includes taxes & fees
10 May - 11 May
Best Western Plus St. Louis West-Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.