Find hotels in Defiance, MO from 1.800.257 ₫

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4 Dec - 5 Dec
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5 Dec - 6 Dec
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5 Dec - 7 Dec
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12 Dec - 14 Dec

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Top 10 Defiance hotels and places to stay

Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very good, (1026)
"Very friendly staff "
United States
Amber
The price is 2.241.535 ₫
2.589.105 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ballroom
The Wildwood Hotel

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1599)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
The price is 2.042.470 ₫
2.482.351 ₫ total
includes taxes & fees
16 Dec - 17 Dec
The Wildwood Hotel
Lobby
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1027)
"The room was great and the bed was very comfortable "
United States
Joyce
The price is 2.610.729 ₫
3.028.446 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Best Western Plus St. Louis West-Westport
Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is 2.018.964 ₫
2.316.256 ₫ total
includes taxes & fees
8 Dec - 9 Dec
Baymont by Wyndham Warrenton
Front of property
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
Chesterfield
8.0 out of 10, Very good, (1030)
"Clean room,Friendly staff, Good location and Good Breakfast options"
United States
Micheal
The price is 2.447.229 ₫
2.838.491 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Sonesta ES Suites St. Louis - Chesterfield
Lobby
AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (234)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is 3.138.387 ₫
3.640.152 ₫ total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel by Marriott St. Louis Chesterfield
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
9.8 out of 10, Exceptional, (15)
"Very nice:) "
United States
Alicia
The price is 1.951.454 ₫
2.243.196 ₫ total
includes taxes & fees
9 Dec - 10 Dec
WoodSpring Suites St Peters-OFallon
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (828)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is 2.188.793 ₫
2.581.682 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1001)
"Nice breakfast, friendly staff"
United States
Damon
The price is 2.278.454 ₫
2.687.438 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very good, (1002)
"Great breakfast, clean room, hot tub!"
United States
Tony
The price is 2.299.551 ₫
2.642.806 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn St. Charles St. Peters
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (831)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is 2.721.487 ₫
3.273.812 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1002)
"Hotel was very clean."
United States
christine
The price is 3.032.401 ₫
3.515.254 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Drury Plaza Hotel St. Louis St. Charles
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

2.0 star property
St. Peters
6.4 out of 10, (1000)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is 1.591.490 ₫
1.829.418 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Days Inn by Wyndham St Peters/St Charles
Front of property – evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2219)
"Decent room. Well priced and centrally located for out soccer tournament we were in town for"
United States
Travis
The price is 2.030.303 ₫
2.748.912 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hollywood Casino & Hotel St. Louis
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
Fenton
7.8 out of 10, Good, (1101)
"The young lady that checked us in was very friendly and helpful."
United States
Wenona
The price is 2.084.628 ₫
2.407.673 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Wingate by Wyndham St. Louis/Fenton Route 66
Egyptian cotton sheets, premium bedding, pillow-top beds, desk
Best Western Plus Washington Hotel

Best Western Plus Washington Hotel

2.5 star property
Washington
9.2 out of 10, Wonderful, (634)
"Would stay again. "
United States
Alisa
The price is 3.401.859 ₫
3.873.017 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Best Western Plus Washington Hotel
In-room safe, desk, laptop workspace, blackout curtains
Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton

2.0 star property
Warrenton
7.4 out of 10, Good, (619)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is 1.569.194 ₫
1.800.257 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Super 8 by Wyndham Warrenton
Daily buffet breakfast (USD 12.95 per person)
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3.0 star property
Chesterfield
8.2 out of 10, Very good, (782)
"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"
United States
Roy
The price is 2.573.810 ₫
2.994.962 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hilton Garden Inn Chesterfield
Interior entrance
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

2.5 star property
St. Charles
5.8 out of 10, (1000)
"Nice staff, respectful."
United States
LaurenRenee
The price is 1.568.811 ₫
1.818.676 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Front of property
Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1008)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
The price is 1.624.454 ₫
1.892.294 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Eureka/Six Flags Nearby
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savour the top-notch restaurants.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savour the top-notch restaurants.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

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A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent
"Everything "
Jojuana 2-night trip
Posted 5 days ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

More cheap stays in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is 1.661.373 ₫ per night from 7 Dec to 8 Dec
1.661.373 ₫
1.909.260 ₫ total
7 Dec - 8 Dec
includes taxes & fees
6.4/10 (999 reviews)

Hotels in Defiance with star rating

Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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