Find hotels in Defiance, MO from 1.815.334 ₫

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11 Dec - 12 Dec
Tomorrow
12 Dec - 13 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Defiance hotels

Property entrance
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1604)
Located near Six Flags St. Louis and Skid Row, this Wildwood retreat offers an indoor pool for morning dips. Travellers praise the helpful staff, comfy beds, and convenient parking. Enjoy free breakfast, WiFi, and business-friendly amenities.
"Great place!"
United States
Biju
The Wildwood Hotel
Reception
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1035)
Stay minutes from Museum of Transport at this serene Fenton hotel with both indoor and outdoor pools. The fitness centre keeps workouts on track while free breakfast, WiFi, and parking add value. Guests praise the helpful staff and convenient access to local attractions.
"Everything was clean and friendly staff overall good experience "
United States
dennis
The price is 2.237.965 ₫
2.584.981 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.8 out of 10, Exceptional, (17)
Located in St. Peters, this hotel provides free WiFi and parking with a 24-hour front desk for your comfort. Nearby attractions include Bowlero St. Peters, CarShield Field, and Ameristar Casino St. Charles.
"The room was super clean and tidy. The staff was very friendly and overall a great experience. "
United States
Fred
The price is 1.948.346 ₫
2.239.623 ₫ total
includes taxes & fees
23 Dec - 24 Dec
WoodSpring Suites St Peters-OFallon
Lobby
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1029)
Experience comfortable lodging minutes from Ameristar Casino St. Charles in a peaceful atmosphere. Guests love the complimentary breakfast, outdoor pool, and fitness centre. Located in Maryland Heights with many dining options and free parking, the helpful staff ensures a pleasant stay.
"The room was great and the bed was very comfortable "
United States
Joyce
The price is 2.215.585 ₫
2.569.814 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus St. Louis West-Westport
Exterior
AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield
3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (237)
Experience contemporary comfort at this business-friendly hotel near Chesterfield Amphitheatre. Work out in the fitness centre, unwind at the stylish bar, or relax in the garden. With free WiFi, parking, and easy access to local attractions, convenience meets sophistication.
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is 3.133.151 ₫
3.634.080 ₫ total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel by Marriott St. Louis Chesterfield
Indoor pool
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
Escape to this quiet retreat offering a relaxing indoor pool, free continental breakfast, and convenient parking. Located near Veteran's Memorial and Dyer Park, the helpful staff and pristine rooms create a peaceful environment for business or leisure travellers.
"Room very clean, most of staff helpful"
United States
Ranata
The price is 2.017.892 ₫
2.315.027 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Baymont by Wyndham Warrenton
Front of property
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield
3.0 star property
Chesterfield
8.0 out of 10, Very good, (1029)
Enjoy complimentary breakfast, WiFi, and parking at this Chesterfield hotel featuring a seasonal outdoor pool and 24-hour fitness centre. Conveniently located near Sophia M. Sachs Butterfly House with helpful staff and clean rooms that guests consistently praise.
"Clean room,Friendly staff, Good location and Good Breakfast options"
United States
Micheal
The price is 2.290.623 ₫
2.656.847 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sonesta ES Suites St. Louis - Chesterfield
Indoor pool
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1005)
Convenient location just 10 minutes from Ameristar Casino and Cave Spring Golf Centre. The indoor pool provides year-round swimming, while free breakfast, WiFi, and parking add value. Travellers praise the helpful staff at this St. Charles hotel.
"Great staff, clean room. "
United States
Amanda
The price is 2.295.889 ₫
2.638.597 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn St. Charles St. Peters
Premium bedding, desk, iron/ironing board, free WiFi
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1000)
Enjoy a refreshing morning swim in the indoor pool after a restful night on the comfortable beds. Free breakfast, WiFi, and parking enhance your stay. Weldon Spring Site and Golf Headquarters are nearby, with St. Louis Lambert Airport just 27 minutes away.
"Nice breakfast, friendly staff"
United States
Damon
The price is 2.203.737 ₫
2.599.306 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (833)
Take a refreshing dip in the indoor pool or maintain your workout routine at the fitness centre. Just a short distance from Weldon Spring Site and Golf Headquarters, this hotel offers free breakfast, WiFi and parking with exceptional staff.
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is 2.185.307 ₫
2.577.569 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (836)
Take a refreshing swim in the indoor pool at this Wentzville hotel near Vietnam Veterans Memorial. Enjoy complimentary breakfast, WiFi, and parking daily. The 24-hour fitness centre keeps your workout routine on track while helpful staff ensures a pleasant stay.
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is 2.896.190 ₫
3.475.295 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.4 out of 10, (1000)
Tucked in St. Peters, this welcoming hotel offers a fitness centre and complimentary WiFi. Start your day with continental breakfast before exploring nearby Bowlero St. Peters and Mid Rivers Mall. Ameristar Casino St. Charles is just a short drive away.
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is 1.678.474 ₫
1.929.405 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Days Inn by Wyndham St Peters/St Charles
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1001)
Start the day with free breakfast at this St. Charles hotel. Unwind in the hot tub or indoor/outdoor pools. Free parking, helpful staff, and proximity to Lewis & Clark Boathouse make this a practical choice for business travellers.
"The stay was perfect. Very clean, quiet and comfortable. The staff were very friendly and helpful. I will stay again. "
United States
holly
The price is 3.027.572 ₫
3.509.656 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Drury Plaza Hotel St. Louis St. Charles
Front of property – evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2216)
Steps from Hollywood Casino, this relaxing hotel offers 7 restaurants and 3 bars. Guests love the quiet atmosphere, helpful staff, and proximity to Ameristar Casino. A free airport shuttle and 24-hour fitness centre enhance your stay.
"Front staff was very friendly and very helpful. Check-in and check out was smooth and very easy. "
United States
James
The price is 2.764.282 ₫
3.607.337 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hollywood Casino & Hotel St. Louis
Lobby
Best Western Plus Washington Hotel

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (635)
Enjoy 24-hour fitness and indoor pool with hot tub at this Washington hotel near the train station. Free breakfast, WiFi, and parking add value, while rooms include refrigerators and microwaves. Guests consistently praise the helpful staff and morning meal options.
"One of our favorites! This hotel is very clean, breakfast is very good and the kids love the indoor pool."
United States
Debra
The price is 3.396.441 ₫
3.866.848 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Best Western Plus Washington Hotel
Interior entrance
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.8 out of 10, (1000)
Situated within walking distance of Ameristar Casino St. Charles, this hotel offers easy access to local dining and shopping. Enjoy free continental breakfast, WiFi, and parking, plus a fitness centre for travellers who appreciate well-maintained accommodation.
"Nice staff, respectful."
United States
LaurenRenee
The price is 1.565.928 ₫
1.815.334 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free cots/infant beds
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1108)
Surprisingly quiet at night, this Fenton hotel offers a convenient base near restaurants and attractions. Take advantage of the outdoor pool, daily continental breakfast, and free WiFi. Nearby Museum of Transport and easy access to Kirkwood Station enhance your stay.
"The young lady that checked us in was very friendly and helpful."
United States
Wenona
The price is 2.081.307 ₫
2.403.837 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Wingate by Wyndham St. Louis/Fenton Route 66
Free daily continental breakfast
Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (620)
This Warrenton motel offers peaceful accommodation with minimal noise between rooms. Enjoy complimentary continental breakfast, WiFi and parking. Located near Truesdale Park and Dyer Park with easy access to St. Louis Lambert Airport.
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is 1.568.242 ₫
1.799.165 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Super 8 by Wyndham Warrenton
Suite, 1 King Bed, Non Smoking (Upgraded) | In-room safe, laptop workspace, blackout curtains, iron/ironing board
Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO
2.0 star property
St. Clair
7.2 out of 10, Good, (943)
Located in St. Clair near Indian Harvest and College Hill Park, this hotel offers free WiFi, parking, and daily on-the-go breakfast. Just 21 minutes from Washington Station with attentive staff ready to ensure a pleasant stay.
"Was what I needed after a long drive."
United States
Michael
The price is 1.753.511 ₫
1.919.656 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Super 8 by Wyndham St. Clair MO
Daily buffet breakfast (USD 12.95 per person)
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield
3.0 star property
Chesterfield
8.2 out of 10, Very good, (783)
Take a dip in the indoor pool after exploring nearby Topgolf or The J fitness centre. This hotel offers comfortable rooms with refrigerators and microwaves, plus a restaurant serving 3 meals daily and a welcoming bar.
"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"
United States
Roy
The price is 2.569.710 ₫
2.990.192 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton Garden Inn Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savour the top-notch restaurants.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savour the top-notch restaurants.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent
"Clean room, easy check in"
lizbeth 1-night trip
Posted 5 days ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

More cheap stays in Defiance

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive St. Charles MO
The price is 1.565.928 ₫ per night from 21 Dec to 22 Dec
1.565.928 ₫
1.815.334 ₫ total
21 Dec - 22 Dec
includes taxes & fees
5.6/10 (1,003 reviews)

Hotels in Defiance with star rating

Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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