Find hotels in Defiance, MO from 1.627.474 ₫

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Go beyond your typical stay in Defiance

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Check prices for these dates

Tonight
10 Nov - 11 Nov
Tomorrow
11 Nov - 12 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,158 reviews)
"Rooms are very clean, the staff is friendly and the location is great. We enjoyed are stay."
United States
Matthew
The price is 2.083.166 ₫
2.457.094 ₫ total
includes taxes & fees
3 Dec - 4 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive
An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

2. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (336 reviews)
"Excellent 1 night stay. Clean and comfortable"
United States
Thomas
The price is 3.114.538 ₫
3.655.315 ₫ total
includes taxes & fees
17 Nov - 18 Nov
TownePlace Suites by Marriott St. Louis Chesterfield
A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.4 out of 10, Very good, (1,003 reviews)
"This was a clean, safe and convenient place to stay while traveling through St. Louis."
United States
Greg
The price is 2.578.429 ₫
3.041.257 ₫ total
includes taxes & fees
18 Nov - 19 Nov
Holiday Inn Express St. Louis West - O'Fallon by IHG
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

4. The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,683 reviews)
"Clean, quiet, great continental breakfast, and close to several places to eat."
United States
Lori
The price is 2.042.254 ₫
2.378.980 ₫ total
includes taxes & fees
6 Dec - 7 Dec
The Wildwood Hotel
A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

5. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
O'Fallon
8.4 out of 10, Very good, (489 reviews)
"We were very happy with our stay. The room exceeded our expectations. The beds were comfortable. It was very clean, and it also smelled good! We will definitely stay here again."
United States
Sal
The price is 3.020.564 ₫
3.562.756 ₫ total
includes taxes & fees
12 Nov - 13 Nov
Staybridge Suites O'Fallon Chesterfield by IHG
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

6. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
Chesterfield
7.8 out of 10, Good, (1,007 reviews)
"Mindy was very nice. Bed not so much, please keep a smoke detector in the room instead of taking it apart."
United States
Charissa
The price is 2.140.607 ₫
2.580.227 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn & Suites Chesterfield - St. Louis
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

7. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
3.0 star property
O'Fallon
8.4 out of 10, Very good, (509 reviews)
"Beautiful room, very clean with nice staff"
United States
Rianna
The price is 3.344.299 ₫
3.944.601 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Residence Inn by Marriott O'Fallon
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (767 reviews)
"Everything you could need for an overnight or extended stay. Staff was extremely helpful, and the property is well-maintained."
United States
Duane
The price is 3.035.398 ₫
3.599.224 ₫ total
includes taxes & fees
3 Dec - 4 Dec
Hilton Garden Inn St. Louis/O'Fallon MO
A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

9. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,001 reviews)
"Great hotel!"
United States
Rob
The price is 3.344.299 ₫
3.895.707 ₫ total
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn St. Louis West Six Flags by IHG
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

10. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (413 reviews)
"Great hotel and Breakfast is nothing special but it makes sense for the price you pay."
United States
Chantelle
The price is 2.158.477 ₫
2.470.697 ₫ total
includes taxes & fees
30 Nov - 1 Dec
Quality Inn Near Six Flags St. Louis
A modern hotel dining area with a long communal table, multiple chairs, and pendant lighting.

11. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (923 reviews)
"Incredibly clean and modern room and building. Friendly and helpful front desk staff, free shuttle (so helpful), and super close to a bunch of stuff. Would stay again, for longer next time!"
United States
Ellen
The price is 2.799.255 ₫
3.257.297 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn & Suites St. Louis/Chesterfield
An outdoor patio area with wicker furniture and a central fire feature.

12. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (684 reviews)
"The room was beautiful and clean. We enjoyed the pool and the bar while we were there. Great amenities!"
United States
Brittney
The price is 2.799.255 ₫
3.257.297 ₫ total
includes taxes & fees
19 Nov - 20 Nov
Courtyard by Marriott St. Louis Chesterfield
A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,001 reviews)
"We drove across America and this property stood out by just having the most comfortable beds and a great breakfast , great staff ."
United States
Terry
The price is 2.808.190 ₫
3.267.695 ₫ total
includes taxes & fees
19 Nov - 20 Nov
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

14. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,014 reviews)
"Very nice hotel and lovely room"
United States
Karin
The price is 3.308.558 ₫
3.837.530 ₫ total
includes taxes & fees
12 Nov - 13 Nov
Hyatt Place St. Louis/Chesterfield
A spacious lobby with a central round table, two sofas, and a chandelier.

15. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,319 reviews)
"Great stay. Food was great. Location is great. Will stay again."
United States
Sara
The price is 3.318.515 ₫
3.849.080 ₫ total
includes taxes & fees
15 Nov - 16 Nov
Drury Plaza Hotel St. Louis Chesterfield
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

16. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (1,002 reviews)
"The breakfast was mediocre and there was road noise but other than that, it was a nice stay."
United States
Scott
The price is 2.222.044 ₫
2.543.685 ₫ total
includes taxes & fees
1 Dec - 2 Dec
Comfort Inn Near Six Flags St. Louis
A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

17. Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (741 reviews)
"We had a great stay during the fall festival that was held in Washington, MO. Nice hotel."
United States
Carl
The price is 3.420.886 ₫
3.894.704 ₫ total
includes taxes & fees
11 Nov - 12 Nov
Best Western Plus Washington Hotel
An outdoor patio with a built-in grill, seating area, and stone walls.

18. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (264 reviews)
"Would stay here again!"
United States
Chelsea
The price is 4.824.981 ₫
5.644.647 ₫ total
includes taxes & fees
21 Nov - 22 Nov
Residence Inn by Marriott St. Louis Chesterfield
A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

19. Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
2.0 star property
Eureka
7.0 out of 10, Good, (1,001 reviews)
"Nice hotel for a quick Six Flags trip. No complaints!"
United States
Laura
The price is 1.627.474 ₫
1.895.811 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Super 8 by Wyndham Eureka/Six Flags Nearby
A modern living room with a stone fireplace, a large window, and a seating area with a coffee table.

20. Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (729 reviews)
"The hotel was very clean and the staff was friendly. It was perfect for our weekend stay for a family wedding."
United States
Melissa
The price is 3.264.649 ₫
3.736.390 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Fairfield Inn & Suites Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels recommended for families in Defiance

A hotel room with a bed, a sofa, a coffee table, and wall art.

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,158)
The price is 2.083.166 ₫
2.457.094 ₫ total
includes taxes & fees
3 Dec - 4 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive

Stay near popular Defiance attractions

Chandler Hill Vineyards

7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
Wildwood

10/10 Excellent

Interesting building, spacious, comfortable rooms. Lovely location, quiet but good local amenities. Friendly, helpful staff. A great experience, thank you.
United Kingdom
Lisa
Reviewed September 9, 2026
The Wildwood Hotel

Frequently Asked Questions

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.