A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Search Holiday Rentals in Defiance

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months
Save an average of 15% on thousands of hotels when you're signed in

Top Defiance Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Can I find holiday rentals in Defiance?

Yes, we have holiday rentals where you'll be just 9.8 mi (15.8 km) from Six Flags St. Louis, giving you a more secluded option if you want peace and quiet. Defiance is known for its wineries and parks.

How many holiday rentals will I find in Defiance?

With 3 Expedia holiday rentals, you're guaranteed to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a holiday rental in Defiance like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Defiance. Holiday rentals feature amenities such as hot tubs, fire pits and patios so you'll have everything you want. If you're concerned about a sanitised environment, holiday rentals can offer a sense of security away from shared hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a traditional hotel, which makes a holiday rental an attractive option for families.