
Downtown Clayton Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by Najib Tecle
Where to stay in Downtown Clayton
Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Downtown Clayton

Downtown St. Louis
3 out of top 10 points of interest in this area
4.5/5(18 area reviews)
Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.
Top hotels in Downtown Clayton

Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is 2.715.388 ₫ per night from 19 Oct to 20 Oct
2.715.388 ₫
3.169.889 ₫ total
19 Oct - 20 Oct
includes taxes & fees
8.8/10 Excellent! (2,958 reviews)
"Breakfast is great. The size of the room is good. The parking garage is convenient. However, you will not have a clean room with fresh towels unless you book the room service daily in the morning, which is confusing."
Reviewed on 7 Oct 2025

AC Hotel St. Louis Clayton
227 South Central Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is 3.216.530 ₫ per night from 2 Nov to 3 Nov
3.216.530 ₫
3.754.913 ₫ total
2 Nov - 3 Nov
includes taxes & fees
9.2/10 Wonderful! (192 reviews)
"Beautiful property and the rooftop was a blast. Rooms were immaculate. Service was great."
Reviewed on 6 Oct 2025

Le Méridien St. Louis Clayton
7730 Bonhomme Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is 4.232.901 ₫ per night from 2 Nov to 3 Nov
4.232.901 ₫
4.983.734 ₫ total
2 Nov - 3 Nov
includes taxes & fees
8.8/10 Excellent! (661 reviews)
"The room was clean and service was excellent."
Reviewed on 7 Sept 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Popular places to visit

St. Louis Union Station
4.5/5(4 reviews)
You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's great live music or attend a baseball game.

Gateway Arch
5/5(16 reviews)
Find out about the history of Gateway Arch, one of the top monuments in St. Louis. Experience the area's acclaimed art galleries or attend a baseball game.

St. Louis Zoo
Why not visit the animals who live at St. Louis Zoo during your holiday in St. Louis? Amble around the area's lush forest or attend a sporting event.