The Best Hotels in Downtown South San Francisco, San Francisco - 2026 Updated Prices

Aerial View of a Local High School and an Athletic Field in a Neighborhood in South San Francisco, California, USA

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

See properties

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

See properties

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

See properties

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to Chase Center – discover South of Market, a destination also famous for its shopping.

See properties

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.

See properties

Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"We chose Riu San Francisco due to the location near to the pick-up/drop-off for planned tours and that worked very well. The room was clean and housekeeping kept it clean during our 5-night stay. The rooms were a bit noisy and not well insulated for sound. The touristy neighborhood around the hotel was dirty…. not the fault of Riu because their areas were very clean, but once you leave the hotel, not so much. The very best part of our stay was the breakfast buffet that we enjoyed every morning! Lots of choices and very fresh and delicious!"

The Marina Inn on San Francisco Bay

10/10 Excellent

"The staff has a good customer service skills like Mona, Jennifer, & the other pilipino lady with glasses. They always got people cleaning, making sure the property is clean. When I use to order foods for delivery, they always call me & let me know that my orders arrived. Even if there were times there were spiders & WiFi isn't excellent, I like this property. There are cats around there which is ok because I love cats & it's by the water as well I just like the location because it's by the water & the sound of the airplane is relaxing. Even if there's no street lights by the golf course or before you even enter, I still like this location, but most of all, great customers service"

La Quinta Inn & Suites by Wyndham San Francisco Airport N

8/10 Good

"The hot breakfast was very nice it consisted of eggs some type of meat there were hash browns as well as cereal and waffle maker I will say that the front desk staff was more than helpful there is a lovely middle-aged Hispanic lady who works the front desk on the weekdays during the mornings she was absolutely fantastic I was trying to walk to a Catholic mass she gave me directions to the nearest church I was able to find it easily I also found out while I was there that my grandmother passed away the same lady went above and beyond to make sure that I was okay and she doesn't even know me the only thing I can say that was bad was the airport shuttle doesn't seem to actually run on a reliable schedule but other than that it was a great day I look forward to coming back to San Francisco again soon"

Frequently asked questions

What's it like in Downtown South San Francisco?

You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.

How many hotels should I expect to find in the Downtown South San Francisco area?

When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 11 Expedia hotels and other accommodation options in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.

What can I see and do in this South San Francisco neighbourhood?

South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed are also worth a visit when you're out sightseeing in South San Francisco.

Search Hotels in Downtown South San Francisco, San Francisco

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

3. Inn By The SFO

4. Miller Apartments

5. La Quinta Inn & Suites by Wyndham Oakland - Hayward

6. Hotel Shattuck Plaza

7. Holiday Inn Express Hotel & Suites Oakland-Airport by IHG

8. The Marina Inn on San Francisco Bay

9. Executive Inn & Suites Embarcadero Cove

10. Hampton Inn Oakland Downtown-City Center

11. Marina Village Inn

12. Hyatt Place Emeryville/San Francisco Bay Area

13. HYATT house Emeryville/San Francisco Bay Area

14. Sonesta Emeryville - San Francisco Bay Bridge

15. Hampton Inn & Suites Oakland Airport-Alameda

16. DoubleTree by Hilton Hotel Berkeley Marina

17. Menlo Park Inn

18. Atherton Park Inn & Suites

19. Good Nite Inn - Redwood City

20. Hotel Griffon

Where to stay in Downtown South San Francisco

Fisherman's Wharf

Union Square

Downtown San Francisco

South of Market

Nob Hill

Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Frequently asked questions

Explore a world of travel with Expedia