Find hotels in East Prairie, MO from 1.667.700 ₫

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2 Dec - 3 Dec
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3 Dec - 4 Dec
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5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

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Top 10 East Prairie hotels and places to stay

1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1009)
"A great stay in every aspect. "
United States
Gertrude
The price is 1.658.610 ₫
1.890.400 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Days Inn and Suites by Wyndham Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (437)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is 2.510.329 ₫
2.842.320 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
Sikeston
8.6 out of 10, Excellent, (442)
"Clean and nice facilities. All the staff we met were friendly and helpful. Breakfast was great."
United States
Kristen
The price is 2.510.329 ₫
2.842.320 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express & Suites Sikeston Southwest by IHG
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very good, (1006)
"Nice location. Great staff. "
United States
Carla
The price is 2.218.688 ₫
2.528.751 ₫ total
includes taxes & fees
8 Dec - 9 Dec
Best Western Plus Sikeston
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very good, (715)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is 1.463.216 ₫
1.667.700 ₫ total
includes taxes & fees
4 Dec - 5 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 star property
Union City
9.2 out of 10, Wonderful, (312)
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is 2.106.883 ₫
2.501.923 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Sleep Inn at Discovery Park of America
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (611)
"Staff was great! Room was nice. "
United States
Lana
The price is 1.546.542 ₫
1.716.275 ₫ total
includes taxes & fees
4 Dec - 5 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
The price is 2.029.841 ₫
2.333.302 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Pear Tree Inn Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
Sikeston
6.6 out of 10, (561)
"ALL GREAT"
United States
NELSON
The price is 1.524.128 ₫
1.737.190 ₫ total
includes taxes & fees
4 Dec - 5 Dec
Super 8 by Wyndham Sikeston/Miner Area
Seasonal outdoor pool
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

2.5 star property
Union City
6.8 out of 10, (365)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is 1.434.737 ₫
1.703.964 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Hospitality House Union City I 69 / US 51
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1010)
"Clean room, great location and friendly staff"
United States
Mark
The price is 2.372.586 ₫
2.727.723 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Drury Inn & Suites Sikeston, MO
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 star property
Union City
8.4 out of 10, Very good, (483)
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is 1.770.678 ₫
2.102.679 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Quality Inn Union City US 51
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 star property
Sikeston
8.4 out of 10, Very good, (280)
"Room was clean, breakfast was very good. "
United States
Connie
The price is 2.218.951 ₫
2.529.049 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Comfort Inn & Suites Sikeston I-55
Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
Sikeston
9.2 out of 10, Wonderful, (37)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is 2.663.269 ₫
3.015.485 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Fairfield Inn & Suites by Marriott Sikeston
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is 1.898.304 ₫
2.254.286 ₫ total
includes taxes & fees
4 Dec - 5 Dec
Country Hearth Inn & Suites Union City
Bar (on property)
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is 3.003.429 ₫
3.400.632 ₫ total
includes taxes & fees
7 Dec - 8 Dec
TownePlace Suites by Marriott Sikeston
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

2.5 star property
Union City
9.6 out of 10, Exceptional, (162)
"Staff was very friendly, room was quiet, easy to get to. Room was clean and comfortable❤️"
United States
Diana
The price is 2.299.377 ₫
2.730.510 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hampton Inn Union City
Free daily buffet breakfast
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

2.5 star property
Union City
9.4 out of 10, Exceptional, (308)
"It was a great hotel! No complaints. Loved the front staff!"
United States
Felicia
The price is 2.510.329 ₫
2.981.016 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express & Suites Union City by IHG
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (272)
"Break fast was excellent "
United States
Uma
The price is 1.896.195 ₫
2.104.397 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Quality Inn Cairo I-57
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 star property
Portageville
8.0 out of 10, Very good, (723)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Extremely clean, and it looks to be updated in the more recent years. Large workout room that looks into the pool. Hot and tasty breakfast. "
John 1-night trip
Posted 2 weeks ago
Fairfield Inn & Suites by Marriott Sikeston

More cheap stays in East Prairie

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is 1.658.610 ₫ per night from 16 Dec to 17 Dec
1.658.610 ₫
1.890.400 ₫ total
16 Dec - 17 Dec
includes taxes & fees
7.2/10 Good! (1,006 reviews)

Hotels in East Prairie with star rating

Frequently asked questions

What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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