Search Hotels in Guayaquil, Cali

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
22 Dec - 23 Dec
Tomorrow
23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Guayaquil hotels

2 outdoor pools
Hotel Real Elim International

Hotel Real Elim International

Hotel Real Elim International
4.5 star property
18.4 km from Guayaquil
9.0 out of 10, Wonderful, (298)
"Excellent location very close to the airport; modern and clean beautiful hotel. "
United States
Carlos
Hotel Real Elim International
Front of property
HOTEL HYM SAS

HOTEL HYM SAS

HOTEL HYM SAS
2.5 star property
26.8 km from Guayaquil
8.8 out of 10, Excellent, (3)
"Staff was friendly. The towels and linens were a bit dingy and the check in counter had a musty smell and a little disorganized. "
United States
Lucy
The price is 1.891.859 ₫
1.891.859 ₫ total
23 Dec - 24 Dec
HOTEL HYM SAS
Standard Room, Multiple Beds | Premium bedding, desk, soundproofing, iron/ironing board
Hotel Thama Palmira

Hotel Thama Palmira

Hotel Thama Palmira
3.0 star property
27.2 km from Guayaquil
8.2 out of 10, Very good, (91)
"Everything was fine "
United States
Gary
The price is 1.284.992 ₫
1.284.992 ₫ total
25 Dec - 26 Dec
Hotel Thama Palmira
Bar (on property)
Hilton Garden Inn Cali Ciudad Jardin

Hilton Garden Inn Cali Ciudad Jardin

Hilton Garden Inn Cali Ciudad Jardin
3.5 star property
Ciudad Jardín, 8 km from Guayaquil
8.8 out of 10, Excellent, (459)
"Great breakfast options!"
United States
CARLOS
The price is 1.861.589 ₫
1.861.589 ₫ total
11 Jan - 12 Jan 2026
Hilton Garden Inn Cali Ciudad Jardin
Outdoor pool
Hotel Spirito by Spiwak

Hotel Spirito by Spiwak

Hotel Spirito by Spiwak
3.5 star property
4.1 km from Guayaquil
8.4 out of 10, Very good, (745)
"Everything was very good!! "
United States
carlos Manuel Ramos
The price is 2.030.623 ₫
2.030.623 ₫ total
2 Jan - 3 Jan 2026
Hotel Spirito by Spiwak
Restaurant
Mirago Hotel

Mirago Hotel

Mirago Hotel
2.5 star property
6.3 km from Guayaquil
10.0 out of 10, Exceptional, (1)
"Excelente todo!"
Colombia
Michael
The price is 1.320.861 ₫
1.320.861 ₫ total
5 Jan - 6 Jan 2026
Mirago Hotel
Exterior detail
Hotel Spiwak Chipichape Cali

Hotel Spiwak Chipichape Cali

Hotel Spiwak Chipichape Cali
4.5 star property
Chipichape, 4 km from Guayaquil
8.6 out of 10, Excellent, (1005)
"Great hotel, great location, great service"
United States
Mario
Hotel Spiwak Chipichape Cali
Fountain
Hotel Boutique Villa Casuarinas

Hotel Boutique Villa Casuarinas

Hotel Boutique Villa Casuarinas
3.5 star property
Ciudad Jardín, 8.5 km from Guayaquil
9.8 out of 10, Exceptional, (38)
"It's a dream property in the best neighborhood of Cali. The staff are incredible friendly and helpful with all that you need. An incredible pool, a tennis court, a waterfall, all in the middle of nature with amazing trees. You can order to the pool from a Peruvian restaurant that serves amazing food. They also have spa. "
United States
Jorge
The price is 1.829.943 ₫
1.829.943 ₫ total
23 Dec - 24 Dec
Hotel Boutique Villa Casuarinas
Outdoor pool
NH Cali Royal

NH Cali Royal

NH Cali Royal
4.0 star property
Campestre, 7.7 km from Guayaquil
8.4 out of 10, Very good, (1003)
"Great place, great location!"
United States
Reynaldo Enrique
The price is 1.590.479 ₫
1.590.479 ₫ total
10 Jan - 11 Jan 2026
NH Cali Royal
Outdoor pool
Alko Hotel Casa Nispero

Alko Hotel Casa Nispero

Alko Hotel Casa Nispero
4.0 star property
San Antonio, 1.4 km from Guayaquil
9.4 out of 10, Exceptional, (200)
"Rooms are spacious and beautifully designed."
United States
Mark
The price is 2.577.606 ₫
3.067.351 ₫ total
13 Jan - 14 Jan 2026
Alko Hotel Casa Nispero
Exterior
CasaPance Boutique Hotel

CasaPance Boutique Hotel

CasaPance Boutique Hotel
3.0 star property
10.9 km from Guayaquil
The price is 2.013.097 ₫
2.013.097 ₫ total
23 Dec - 24 Dec
CasaPance Boutique Hotel
Premium Suite, Pool View, GOTICA RED | View from room
Osve Hotel Boutique

Osve Hotel Boutique

Osve Hotel Boutique
4.0 star property
2.2 km from Guayaquil
10.0 out of 10, Exceptional, (2)
"Everything was good. The room, breakfast, the swimming pool..."
Belgium
Katia
The price is 2.179.421 ₫
2.179.421 ₫ total
23 Dec - 24 Dec
Osve Hotel Boutique
Restaurant
Hotel Pance 122

Hotel Pance 122

Hotel Pance 122
3.5 star property
10.7 km from Guayaquil
8.8 out of 10, Excellent, (45)
"Amazing stay!!"
United States
Jahiem
The price is 2.431.210 ₫
2.431.210 ₫ total
2 Jan - 3 Jan 2026
Hotel Pance 122
Outdoor pool, open 8:00 AM to 7:00 PM, pool loungers
Malik Hotel Boutique

Malik Hotel Boutique

Malik Hotel Boutique
3.5 star property
Ciudad Jardín, 8.9 km from Guayaquil
8.4 out of 10, Very good, (76)
"Love the place it was an amazing stay"
United States
Juan
Malik Hotel Boutique
Breakfast, lunch and dinner served
Hotel Obelisco

Hotel Obelisco

Hotel Obelisco
4.0 star property
El Peñon, 2.2 km from Guayaquil
8.6 out of 10, Excellent, (485)
"I have been staying in this Hotel 4 times , this is my hometown and the location is perfect!"
United States
Viviana
The price is 1.690.290 ₫
1.690.290 ₫ total
10 Jan - 11 Jan 2026
Hotel Obelisco
Outdoor pool, open 9:30 AM to 5 PM, pool umbrellas, pool loungers
InterContinental Cali by IHG

InterContinental Cali by IHG

InterContinental Cali by IHG
3.5 star property
El Peñon, 1.8 km from Guayaquil
9.0 out of 10, Wonderful, (1002)
"Nice place to stay in Cali"
United States
Kay
The price is 3.263.060 ₫
3.263.060 ₫ total
3 Jan - 4 Jan 2026
InterContinental Cali by IHG
Terrace/patio
Hotel Marrakech Cali

Hotel Marrakech Cali

Hotel Marrakech Cali
3.0 star property
4.9 km from Guayaquil
The price is 1.270.504 ₫
1.270.504 ₫ total
2 Jan - 3 Jan 2026
Hotel Marrakech Cali
Reception
Tru By Hilton Cali Sur

Tru By Hilton Cali Sur

Tru By Hilton Cali Sur
2.5 star property
9 km from Guayaquil
9.0 out of 10, Wonderful, (72)
"Great stay "
United States
Neda
The price is 1.410.295 ₫
1.410.295 ₫ total
3 Jan - 4 Jan 2026
Tru By Hilton Cali Sur
Restaurant
NH Boulevard Del Río Cali

NH Boulevard Del Río Cali

NH Boulevard Del Río Cali
3.5 star property
Centenario, 1.9 km from Guayaquil
9.0 out of 10, Wonderful, (337)
"Excellent, the staff, location, cleanliness and hospitality. "
United States
David
The price is 1.503.113 ₫
1.503.113 ₫ total
12 Jan - 13 Jan 2026
NH Boulevard Del Río Cali
Outdoor pool, pool umbrellas, pool loungers
Hotel Stein Colonial

Hotel Stein Colonial

Hotel Stein Colonial
3.0 star property
Juanambú, 2 km from Guayaquil
9.2 out of 10, Wonderful, (239)
"Great family hotel"
United States
Rodrigo
The price is 3.440.947 ₫
3.440.947 ₫ total
24 Dec - 25 Dec
Hotel Stein Colonial
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Guayaquil

Find the best Guayaquil areas for the activities you enjoy most.

Ciudad Jardín

Unique features of Ciudad Jardín include the restaurants and shopping. Make a stop by Palmas Mall or Las Velas Shopping Center while you're exploring the area.

Granada

Visitors to Granada enjoy its shopping, and if you want to do some exploring, Lugar a Dudas is worth a stop.

San Antonio

When in San Antonio, you can plan a visit to Centenario Commercial Center and Calima Gold Museum of the Bank of the Republic, some noteworthy sights in the nearby area.

El Peñon

While El Peñon may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Centenario Commercial Center and Rock Park.

Top Guayaquil Hotel Reviews

Frequently asked questions

What is Guayaquil like?
You'll be sure to have fun exploring Cali's Guayaquil neighbourhood.
If I need to cancel my hotel reservation in Guayaquil, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to get the top deals on offer in Guayaquil.
What can I see and do in this Cali neighbourhood?
A few places to visit in the area around Guayaquil include Jovita Monument, Galeria Alameda and Valle del Cauca Government Building. While you're out sightseeing in Cali, make sure that you visit other sights such as Comfandi and Comfenalco Cultural Center or Torre Mudejar.

Explore a world of travel with Expedia