Name: DoubleTree by Hilton Houston Medical Center Hotel & Suites
Price range: 3.215.167 ₫

Stay near popular South Central Houston attractions

A large historic building with a red roof and arched windows, surrounded by a well-maintained garden and a clear blue sky.

Rice University

8.6/10 (1,772 reviews)

Walk around the campus of Rice University, a top university in Houston. Experience the area's acclaimed art galleries and lively festivals.

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A modern building with large windows and a unique architectural design.

Houston Museum of Fine Arts

9.4/10 (258 reviews)

You can spend time studying the exhibits at Houston Museum of Fine Arts during your trip to Houston. Experience the area's acclaimed art galleries and fascinating museums.

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Top hotels in South Central Houston

Hilton Houston Plaza/Medical Center

6633 Travis St Houston TX

2.868.335 ₫

3.386.477 ₫ total

23 Aug - 24 Aug

includes taxes & fees

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in their reviews. ...

Hotel Zaza Houston Museum District

5701 Main Street Houston TX

6.094.817 ₫

8.170.544 ₫ total

3 Aug - 4 Aug

includes taxes & fees

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (1,011 reviews)

"The hotel is amazing, but while I was there, the pool was very cloudy. In addition, $60 to valet my car and $30 amenity fee. These are BS fees!"

Reviewed on 29 Jul 2026

InterContinental Houston by IHG

6750 Main St Houston TX

3.735.883 ₫

4.897.783 ₫ total

21 Aug - 22 Aug

includes taxes & fees

Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and ...

9.4/10 Exceptional! (1,012 reviews)

"I simply looooove the place but specially the staff, so helpful and kind … and the food was just wow! … must go back soon … E!"

Reviewed on 28 Jul 2026

The Westin Houston Medical Center/Museum District

1709 DRYDEN ROAD Houston TX

4.003.827 ₫

4.983.564 ₫ total

1 Aug - 2 Aug

includes taxes & fees

Stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service and a 24-hour health club. Our guests praise the helpful staff and ...

9.2/10 Wonderful! (1,173 reviews)

"Everything was great. Only issue we called for extra sweet and low due to three occupants. I had two friends with me to attend to me after my surgery. I went down stairs after waiting for an hr. The front desk clerk called for them to deliver us the sweet and low. The hostess of the restaurant was ..."

Reviewed on 28 Jul 2026

Houston Marriott Medical Center/Museum District

6580 Fannin Street Houston TX

Fully refundableReserve now, pay when you stay

3.768.539 ₫

5.247.940 ₫ total

29 Aug - 30 Aug

includes taxes & fees

Stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free local area shuttle and room service. Our guests praise the helpful staff ...

DoubleTree by Hilton Houston Medical Center Hotel & Suites

6800 Main Street Houston TX

3.215.167 ₫

3.761.745 ₫ total

22 Aug - 23 Aug

includes taxes & fees

Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff in ...

See all 1,254 properties in South Central Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.