Beautiful sunset with popcorn clouds in San Diego East County with mountain views.

Search Holiday Rentals in La Mesa

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
3 Jul - 5 Jul
In two months
14 Aug - 16 Aug
In three months
11 Sep - 13 Sep
In four months
9 Oct - 11 Oct

Our top choices for La Mesa holiday rentals

House (3 Bedrooms) | Interior

Mt. Nebo Oasis in La Mesa w/ Wraparound Deck

Mt. Nebo Oasis in La Mesa w/ Wraparound Deck
3.0 star property
Windsor Hills
The price is 8.050.860 ₫
19.316.013 ₫ total
includes taxes & fees
22 Jun - 23 Jun
Mt. Nebo Oasis in La Mesa w/ Wraparound Deck
Exterior

Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,108 reviews)
"Great stay! Big room, comfortable"
United States
Christine
The price is 5.130.450 ₫
5.948.500 ₫ total
includes taxes & fees
29 Jun - 30 Jun
Marriott Vacation Club®, San Diego
Beach nearby

Coronado Beach Resort

Coronado Beach Resort
3.0 star property
Historic Downtown Coronado
9.0 out of 10, Wonderful, (796 reviews)
"Great stay"
United States
Vjosa
The price is 9.182.190 ₫
10.100.409 ₫ total
includes taxes & fees
15 Jul - 16 Jul
Coronado Beach Resort
Cottage (2 Bedrooms) | Interior

Yard & Grill! Cottage Near Balboa Park & Comic-con

Yard & Grill! Cottage Near Balboa Park & Comic-con
3.0 star property
South Park
The price is 7.550.970 ₫
15.588.149 ₫ total
includes taxes & fees
10 Jul - 11 Jul
Yard & Grill! Cottage Near Balboa Park & Comic-con
Living area

Gaslamp District Gem Walk to Dining

Gaslamp District Gem Walk to Dining
2.0 star property
Downtown San Diego
The price is 71.037.000 ₫
86.040.278 ₫ total
includes taxes & fees
16 Jun - 17 Jun
Gaslamp District Gem Walk to Dining
Lobby sitting area

Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (391 reviews)
"Great place to stay. Clean, friendly staff."
United States
Heber
The price is 2.820.469 ₫
3.180.078 ₫ total
includes taxes & fees
16 Jun - 17 Jun
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.8 out of 10, Exceptional, (162 reviews)
"Nice and very friendly staff was a great stay"
United States
Alexander
The price is 3.847.837 ₫
5.232.976 ₫ total
includes taxes & fees
28 Jun - 29 Jun
City24 Hotel Little Italy Mission Hills
Outdoor pool

Kasa Little Italy San Diego

Kasa Little Italy San Diego
4.5 star property
Downtown San Diego
9.6 out of 10, Exceptional, (444 reviews)
"The apartment was very clean and spacious. The amenities were amazing, would definitely stay here again and recommend to others."
United States
Tina
The price is 6.288.090 ₫
9.473.342 ₫ total
includes taxes & fees
16 Jun - 17 Jun
Kasa Little Italy San Diego
House, Accessible | 1 bedroom, Internet

Penthouse High-rise Ocean City Views

Penthouse High-rise Ocean City Views
2.0 star property
Downtown San Diego
The price is 13.400.128 ₫
23.846.838 ₫ total
includes taxes & fees
28 Jun - 29 Jun
Penthouse High-rise Ocean City Views
Lobby

Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.4 out of 10, Very good, (144 reviews)
"the rooms were clean, everything was located so close less than 10 mins away! i loved it for our stay"
United States
annalisa
The price is 2.829.504 ₫
3.218.561 ₫ total
includes taxes & fees
16 Jun - 17 Jun
Little Italy Inn - Limited Service Apart Hotel
Apartment (1 Bedroom) | Interior

9 Mi to Beach: Pet-friendly Apt in San Diego!

9 Mi to Beach: Pet-friendly Apt in San Diego!
3.0 star property
Torrey Highlands
The price is 3.183.510 ₫
7.781.709 ₫ total
includes taxes & fees
22 Jun - 23 Jun
9 Mi to Beach: Pet-friendly Apt in San Diego!
Interior

By Seaport Village & Navy Base! Chic Condo w/ Pool

By Seaport Village & Navy Base! Chic Condo w/ Pool
4.0 star property
National City
The price is 7.735.140 ₫
16.313.516 ₫ total
includes taxes & fees
17 Jun - 18 Jun
By Seaport Village & Navy Base! Chic Condo w/ Pool
House (1 Bedroom) | Interior

Walk to Torrey Pines Beach! 'beachwalk Bungalow'

Walk to Torrey Pines Beach! 'beachwalk Bungalow'
3.0 star property
Del Mar Heights
Walk to Torrey Pines Beach! 'beachwalk Bungalow'
House (2 Bedrooms) | Interior

2BR Condo Steps to the Beach & Blvd-dog-friendly

2BR Condo Steps to the Beach & Blvd-dog-friendly
3.0 star property
Mission Beach
The price is 5.788.200 ₫
16.322.461 ₫ total
includes taxes & fees
16 Jun - 17 Jun
2BR Condo Steps to the Beach & Blvd-dog-friendly
Deluxe Studio, 1 Queen Bed (Self Check-in with Virtual Front Desk) | Individually decorated, individually furnished, laptop workspace

Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
Downtown San Diego
7.8 out of 10, Good, (194 reviews)
"Nice place, right at the heart of the night life. I felt very safe and relaxed here. Next time I’m in San Diego I’ll stayed again. Thank you."
United States
marvin
The price is 3.054.591 ₫
3.480.554 ₫ total
includes taxes & fees
30 Jun - 1 Jul
Kasa Gaslamp Quarter San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"The hotel has been recently remodeled the rooms were very clean and the amenities were well kept id definitely recommend this place."
Andre 2-night trip
Posted 5 hours ago
The Alcala Hotel Mission Valley/Seaworld

Frequently asked questions

Are there holiday rentals in La Mesa?

Yes, there are holiday rentals in La Mesa close to La Mesa Memorial Fine Arts Center, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

How many holiday rentals are there in La Mesa?

With 72 Expedia holiday rentals, you're guaranteed to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit one of the family-friendly sights such as San Diego Zoo. While in the area, you can also visit popular places such as Petco Park and Hotel del Coronado.

What are holiday rentals like in La Mesa?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in La Mesa. Holiday rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a sanitised environment, holiday rentals can offer a sense of seclusion away from public hotel lifts and busy concierge desks while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great choice for a small group gathering.