A sunset over a mountainous landscape with scattered clouds.

Search Holiday Rentals in La Mesa

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
11 Sep - 13 Sep
In two months
23 Oct - 25 Oct
In three months
20 Nov - 22 Nov
In four months
18 Dec - 20 Dec

Our top choices for La Mesa holiday rentals

Exterior

1. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,179 reviews)
"Great for traveling families."
United States
Veronica Dangerfield
The price is 3.968.528 ₫
4.601.310 ₫ total
includes taxes & fees
2 Sept - 3 Sept
Marriott Vacation Club®, San Diego
Lobby sitting area

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (446 reviews)
"Room was perfect for our short trip. Clean room and friendly staff."
United States
Diana
The price is 2.438.249 ₫
2.749.126 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Pool

3. Kasa Little Italy San Diego

Kasa Little Italy San Diego
4.5 star property
Downtown San Diego
9.6 out of 10, Exceptional, (509 reviews)
"Definitely would stay again!"
United States
Victor
The price is 5.867.550 ₫
8.973.802 ₫ total
includes taxes & fees
9 Sept - 10 Sept
Kasa Little Italy San Diego
Lobby

4. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.2 out of 10, Very good, (261 reviews)
"Clean rooms, convenient check-in."
United States
Hari
The price is 2.549.594 ₫
2.951.155 ₫ total
includes taxes & fees
28 Sept - 29 Sept
Little Italy Inn - Limited Service Apart Hotel
Beach

5. Coronado Beach Resort

Coronado Beach Resort
3.0 star property
Historic Downtown Coronado
9.0 out of 10, Wonderful, (815 reviews)
"Clean and large room, friendly staff and beach equipment was great to have."
United States
Kimberlee
The price is 5.449.325 ₫
5.994.258 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Coronado Beach Resort
Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio

6. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (192 reviews)
"Enjoyed my stay! Clean spacious room and friendly staff."
United States
omokayode
The price is 3.481.887 ₫
4.812.479 ₫ total
includes taxes & fees
2 Sept - 3 Sept
City24 Hotel Little Italy Mission Hills
Aerial view

7. Wave Crest Resort

Wave Crest Resort
3.0 star property
Del Mar
9.2 out of 10, Wonderful, (157 reviews)
"Beautiful views clean property. "
United States
Irma
The price is 5.613.494 ₫
7.227.292 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Wave Crest Resort
House (2 Bedrooms) | Interior

8. 2BR Condo Steps to the Beach & Blvd-dog-friendly

2BR Condo Steps to the Beach & Blvd-dog-friendly
3.0 star property
Mission Beach
The price is 5.712.177 ₫
15.434.354 ₫ total
includes taxes & fees
30 Aug - 31 Aug
2BR Condo Steps to the Beach & Blvd-dog-friendly
Deluxe Studio, 1 Queen Bed (Self Check-in with Virtual Front Desk)

9. Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
Downtown San Diego
7.8 out of 10, Good, (222 reviews)
"Great stay! Easy virtual check in. Great location in Gaslamp."
United States
Michelle
The price is 2.933.775 ₫
3.342.891 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Kasa Gaslamp Quarter San Diego
House (4 Bedrooms) | Interior

10. < 2 Mi to Pacific Beach! Sunny San Diego Escape

< 2 Mi to Pacific Beach! Sunny San Diego Escape
3.0 star property
Pacific Beach
7.4 out of 10, Good, (3 reviews)
"Strategic location for beach, amusement parks and restaurants. Close to major freeways and airport. House has plenty of room across the three floors. Kids loved seeing the seaworld fireworks from the open air rooftop patio. This property has it all. Owner quickly addressed any of our questions and needs. "
United States
Thomas
The price is 8.892.598 ₫
19.917.855 ₫ total
includes taxes & fees
31 Aug - 1 Sept
< 2 Mi to Pacific Beach! Sunny San Diego Escape
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

San Diego Marriott La Jolla

San Diego Marriott La Jolla

8/10 Good
"This was a decent place with easy access and friendly service. It was a more dated room with some wear and tear inside and throughout the building. The biggest issue was the elevators. Out of three, only 1 worked consistently and was the slowest I’ve ever seen. I waited a full 5 minutes one morning just to go downstairs."
Alexandria 2-night trip
Posted less than an hour ago
San Diego Marriott La Jolla

Frequently asked questions

Are there holiday rentals in La Mesa?

Yes, there are holiday rentals in La Mesa close to La Mesa Memorial Fine Arts Center, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

How many holiday rentals are there in La Mesa?

With 63 Expedia holiday rentals, you're guaranteed to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit one of the family-friendly sights such as San Diego Zoo. While in the area, you can also visit popular places such as Petco Park and Mission Bay.

What are holiday rentals like in La Mesa?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in La Mesa. Holiday rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a sanitised environment, holiday rentals can offer a sense of seclusion away from public hotel lifts and busy concierge desks while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great choice for a small group gathering.