A storefront with a sign reading "The Beach Club" and various clothing items displayed in the window.

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Check prices for these dates

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Main Street Hyannis hotels

A multi-story hotel with balconies, a flat roof, and a clear sky.

1. Hyannis Travel Inn

Hyannis Travel Inn
2.5 star property
0.2 km from Main Street Hyannis
9.6 out of 10, Exceptional, (1,038 reviews)
"Great property, convenient location and helpful staff."
United States
Colleen
The price is 2.551.824 ₫
2.920.421 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Hyannis Travel Inn
A neatly arranged bedroom with a large bed, a bedside table, a chair, a TV mounted on the wall, and a window with blinds.

2. Sea Street Inn

Sea Street Inn
4.0 star property
1.5 km from Main Street Hyannis
9.8 out of 10, Exceptional, (47 reviews)
"Wonderful stay. Great communication. Outstanding breakfast."
United States
John
The price is 6.817.752 ₫
7.802.911 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Sea Street Inn
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.

3. Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
0.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (1,003 reviews)
"Very nice stay with everything we needed. Excellent attention to detail. Great breakfast."
United States
Anita
The price is 3.456.562 ₫
4.693.486 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Anchor In Distinctive Waterfront Lodging
A restaurant with outdoor seating, string lights, and a decorative wall.

4. Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
4.0 star property
1.9 km from Main Street Hyannis
9.2 out of 10, Wonderful, (403 reviews)
"Wonderful stay in delightful hotel. Grounds were immaculate and staff was extremely helpful and welcoming."
United States
Melissa
The price is 2.679.415 ₫
3.173.767 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Uncommoner Hotel by Reverie Boutique Collection
A pool area with lounge chairs and flags.

5. The Cove at Yarmouth by Westgate Resorts

The Cove at Yarmouth by Westgate Resorts
3.0 star property
2.1 km from Main Street Hyannis
9.2 out of 10, Wonderful, (271 reviews)
"The property is an older timeshare and dated."
United States
Kim
The price is 2.770.508 ₫
3.170.847 ₫ total
includes taxes & fees
5 Nov - 6 Nov
The Cove at Yarmouth by Westgate Resorts
A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.

6. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel
2.5 star property
0.3 km from Main Street Hyannis
9.0 out of 10, Wonderful, (198 reviews)
"Very nice place and great location to explore the town."
United States
Holly
The price is 3.264.530 ₫
3.736.255 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
A modern conference room with a long table, chairs, a flat-screen TV, and pendant lighting.

7. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (758 reviews)
"The staff is very friendly. Rooms and common areas are clean and well maintained."
United States
Jeannette
The price is 3.264.530 ₫
3.736.254 ₫ total
includes taxes & fees
9 Nov - 10 Nov
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.

8. Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,582 reviews)
"We had a great stay!"
United States
Lynn
The price is 2.242.512 ₫
2.920.459 ₫ total
includes taxes & fees
15 Nov - 16 Nov
Bayside Resort Hotel
An indoor swimming pool with a high ceiling and large windows.

9. Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
3.0 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (519 reviews)
"Location was good and relaxing"
United States
SHREYASI
The price is 3.272.263 ₫
3.745.106 ₫ total
includes taxes & fees
10 Nov - 11 Nov
Courtyard By Marriott Cape Cod Hyannis
An outdoor patio with wicker furniture, a fire pit, and umbrellas.

10. Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
2.5 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,002 reviews)
"Very quiet and clean hotel."
United States
Carmen E
The price is 2.716.790 ₫
3.109.366 ₫ total
includes taxes & fees
2 Dec - 3 Dec
Hampton Inn & Suites Cape Cod-West Yarmouth
An indoor swimming pool with a brick wall, a white table with chairs, and a large window.

11. Courtyard Resort

Courtyard Resort
2.0 star property
0.3 km from Main Street Hyannis
8.6 out of 10, Excellent, (167 reviews)
"Had a great stay. Very clean and smells so nice. Staff was wonderful. Will stay again"
United States
chris
The price is 3.608.640 ₫
4.130.089 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Courtyard Resort
A DoubleTree hotel with a brick facade and a large sign.

12. Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
0.9 km from Main Street Hyannis
8.4 out of 10, Very good, (953 reviews)
"Great stay"
Canada
Tammie
The price is 3.264.530 ₫
3.736.255 ₫ total
includes taxes & fees
10 Nov - 11 Nov
Doubletree by Hilton Cape Cod - Hyannis
An outdoor seating area with wooden furniture and a fire pit, surrounded by trees and a gravel path.

13. Cape Sands Inn

Cape Sands Inn
2.5 star property
1.9 km from Main Street Hyannis
8.2 out of 10, Very good, (1,160 reviews)
"Staff was excellent hotel clean"
United States
Jerome
The price is 1.922.374 ₫
2.199.982 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Cape Sands Inn
A long dining table with chairs, a kitchen area, and a large window.

14. Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
2.5 star property
0.3 km from Main Street Hyannis
8.2 out of 10, Very good, (1,000 reviews)
"Good breakfast. Indoor pool and spa were nice."
United States
darrell
The price is 2.388.146 ₫
2.733.233 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Comfort Inn Hyannis - Cape Cod
A spacious, modern interior with a high ceiling, a seating area with sofas, a desk with a computer, and a large TV screen.

15. Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
3.0 star property
2.9 km from Main Street Hyannis
8.2 out of 10, Very good, (1,000 reviews)
"Great stay all around !"
United States
Alexander
The price is 3.041.568 ₫
3.481.074 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Hyannis by IHG
A two-story hotel with a curved facade, a balcony, and a sign indicating the lobby.

16. Hyannis Harbor Hotel

Hyannis Harbor Hotel
3.5 star property
0.6 km from Main Street Hyannis
8.2 out of 10, Very good, (1,005 reviews)
"Great location"
United States
Gary
The price is 3.527.446 ₫
4.441.072 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Hyannis Harbor Hotel
A house with a white door, a mailbox, and a sign reading '270 Ocean Ave.'

17. Sea Breeze Inn

Sea Breeze Inn
2.5 star property
1.8 km from Main Street Hyannis
7.8 out of 10, Good, (223 reviews)
"The inn was cozy and clean Directions on the phone to get in the room. Of course I was there off season , but great location. Short walk to the beach. Just lovely, and wonderful for a solo traveler."
United States
Ann
The price is 2.036.304 ₫
2.330.408 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Sea Breeze Inn
A spacious living area with a checkered floor, a wooden staircase, a sofa set, a television, and a potted plant.

18. Hyannis Plaza Hotel

Hyannis Plaza Hotel
2.5 star property
0.9 km from Main Street Hyannis
7.2 out of 10, Good, (1,003 reviews)
"The hotel was excellent and the area was amazing I loved it staff was friendly and help full I definitely will be going back"
United States
Teewonda
The price is 2.453.360 ₫
3.065.630 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Hyannis Plaza Hotel
A hotel room with two beige sofas, a glass coffee table, and a flat-screen TV mounted on the wall.

19. Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area

Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area
2.0 star property
1.5 km from Main Street Hyannis
7.0 out of 10, Good, (1,001 reviews)
"Good location and real clean All good"
United States
Eddy
The price is 1.778.544 ₫
2.035.544 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Days Inn by Wyndham West Yarmouth/Hyannis Cape Cod Area
An indoor swimming pool with clear glass walls, a metal roof, and several Adirondack chairs around the pool.

20. Econo Lodge West Yarmouth on Cape Cod

Econo Lodge West Yarmouth on Cape Cod
2.5 star property
1.5 km from Main Street Hyannis
6.4 out of 10, (557 reviews)
"The room was clean and comfortable. We only stayed one night, off season, so we didn't experience the pool. We had our dogs and there was a nice grassy area in which to walk them."
United States
Denise
The price is 1.932.942 ₫
2.212.251 ₫ total
includes taxes & fees
5 Nov - 6 Nov
Econo Lodge West Yarmouth on Cape Cod
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Main Street Hyannis

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A multi-story hotel with balconies, a flat roof, and a clear sky.
Hyannis Travel Inn
2.5 star property
9.6
Exceptional
1,038 reviews
View
A neatly arranged bedroom with a large bed, a bedside table, a chair, a TV mounted on the wall, and a window with blinds.
Sea Street Inn
4.0 star property
9.8
Exceptional
47 reviews
View
A stone fire pit with four white Adirondack chairs around it, overlooking a marina with boats.
Anchor In Distinctive Waterfront Lodging
3.0 star property
9.4
Exceptional
1,003 reviews
View
A restaurant with outdoor seating, string lights, and a decorative wall.
Uncommoner Hotel by Reverie Boutique Collection
4.0 star property
9.2
Wonderful
403 reviews
View
A pool area with lounge chairs and flags.
The Cove at Yarmouth by Westgate Resorts
3.0 star property
9.2
Wonderful
271 reviews
View

Top Main Street Hyannis Hotel Reviews

Hyannis Travel Inn

Hyannis Travel Inn

10/10 Excellent
"Good continental breakfast"
Leo 1-night trip
Posted 6 hours ago
Hyannis Travel Inn

Other attractions near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)
You can spend an afternoon studying the exhibits at John F. Kennedy Hyannis Museum during your travels in Hyannis. Wander through the beautiful beaches and waterfront in this family-friendly area.
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Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, take a look at the 197 hotels and other accommodation options you'll find within a mile.
How many hotels can I expect to find near Main Street Hyannis?
Expedia has 197 hotels and other accommodation options within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer near Main Street Hyannis.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Centerville Historical Museum and Edward Gorey House feature captivating exhibits. Hyannis Harbor, Sandy Neck Lighthouse and West Parish Meetinghouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Veterans Memorial Park and Dennis Pond Conservation Area are peaceful spots to stop and take in some fresh air.