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Our top choices for Maine Medical Center hotels

Reception
Longfellow Hotel

Longfellow Hotel

Longfellow Hotel
4.0 star property
Parkside, 0.3 km from Maine Medical Center
9.6 out of 10, Exceptional, (139)
"Very stylish, clean, and comfortable hotel. We typically stay in the Oldport section of Portland but it was really nice to explore other areas. Lots of restaurants, bars, and coffee shops in the area. The hotel bar and coffee shop are great and very convenient. Look for those week day deals. Very affordable "
United States
Rachel
Longfellow Hotel
Living area
Blind Tiger Portland – Carleton Street

Blind Tiger Portland – Carleton Street

Blind Tiger Portland – Carleton Street
3.5 star property
West End, 0.4 km from Maine Medical Center
9.6 out of 10, Exceptional, (120)
"Loved the place "
United States
Stephen
The price is 5.108.214 ₫
5.567.953 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Blind Tiger Portland – Carleton Street
Deluxe Suite, 1 King Bed | Private kitchen | Full-sized fridge, microwave, oven, stovetop
The Weldon Hotel

The Weldon Hotel

The Weldon Hotel
4.5 star property
Downtown Portland, 1.4 km from Maine Medical Center
9.8 out of 10, Exceptional, (90)
"Loved this place and would definitely stay here next time we go back."
United States
Eleni
The price is 4.858.069 ₫
9.244.945 ₫ total
includes taxes & fees
29 Dec - 30 Dec
The Weldon Hotel
Baxter | Premium bedding, individually decorated, individually furnished
Blind Tiger Portland - Danforth Street.

Blind Tiger Portland - Danforth Street.

Blind Tiger Portland - Danforth Street.
3.5 star property
West End, 1.1 km from Maine Medical Center
9.6 out of 10, Exceptional, (167)
"The property is beautiful, the staff is kind, and the rooms are spacious and clean. It was great to have a safe place to park the car while having so many things to do within walking distance. Being able to grab a quick breakfast before heading out was great too! We loved our stay here!"
United States
Darby
The price is 5.424.186 ₫
5.912.363 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Blind Tiger Portland - Danforth Street.
Signature Apartment, 2 Bedrooms | Living area | 52-inch LED TV with satellite channels, TV, streaming services
The Docent’s Collection – Thompson Block

The Docent’s Collection – Thompson Block

The Docent’s Collection – Thompson Block
3.5 star property
Old Port, 1.9 km from Maine Medical Center
9.6 out of 10, Exceptional, (257)
"Excellent property and the staff was so wonderful, would definitely come back here!"
United States
ERIC
The price is 4.176.623 ₫
4.552.630 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
The Docent’s Collection – Thompson Block
Bar (on property)
Canopy by Hilton Portland Waterfront

Canopy by Hilton Portland Waterfront

Canopy by Hilton Portland Waterfront
4.0 star property
Old Port, 1.5 km from Maine Medical Center
9.4 out of 10, Exceptional, (1007)
"Wonderful experience ... would definitely come back!"
United States
lynda
The price is 3.217.122 ₫
3.559.423 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Canopy by Hilton Portland Waterfront
Front of property
Portland Regency Hotel & Spa

Portland Regency Hotel & Spa

Portland Regency Hotel & Spa
3.5 star property
Old Port, 1.8 km from Maine Medical Center
9.4 out of 10, Exceptional, (1552)
"Yes, excellent service and we really enjoyed our stay."
United States
Bruce
Portland Regency Hotel & Spa
Breakfast, lunch, dinner served; American cuisine
The Press Hotel, Marriott Autograph Collection

The Press Hotel, Marriott Autograph Collection

The Press Hotel, Marriott Autograph Collection
4.0 star property
Downtown Portland, 1.6 km from Maine Medical Center
9.4 out of 10, Exceptional, (1000)
"Beautiful hotel, good & convenient restaurant and very short walk to Merrill Auditorium"
United States
PETER
The price is 4.118.168 ₫
4.556.341 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
The Press Hotel, Marriott Autograph Collection
Exterior
Cambria Hotel Portland Downtown-Old Port

Cambria Hotel Portland Downtown-Old Port

Cambria Hotel Portland Downtown-Old Port
3.0 star property
East Bayside, 2.3 km from Maine Medical Center
9.4 out of 10, Exceptional, (1135)
"Excellent room and accommodations in nice location near so much of downtown Portland’s charms"
United States
NEWELL
The price is 2.440.308 ₫
3.417.695 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Cambria Hotel Portland Downtown-Old Port
Exterior
Embassy Suites by Hilton Portland Maine

Embassy Suites by Hilton Portland Maine

Embassy Suites by Hilton Portland Maine
3.5 star property
2.9 km from Maine Medical Center
9.4 out of 10, Exceptional, (1130)
"Room was spotless and the staff was extremely friendly and knowledgeable! Would definitely stay here again!"
United States
Lori ann
The price is 2.619.935 ₫
2.898.695 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Embassy Suites by Hilton Portland Maine
Exterior
Courtyard Portland Downtown/Waterfront

Courtyard Portland Downtown/Waterfront

Courtyard Portland Downtown/Waterfront
3.0 star property
Old Port, 1.5 km from Maine Medical Center
9.2 out of 10, Wonderful, (1003)
"Clean, comfortable stay!"
United States
John
The price is 2.439.567 ₫
2.699.137 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Courtyard Portland Downtown/Waterfront
Restaurant
Portland Harbor Hotel

Portland Harbor Hotel

Portland Harbor Hotel
4.0 star property
Old Port, 1.6 km from Maine Medical Center
9.2 out of 10, Wonderful, (1714)
"Beautiful room, friendly staff, and perfect location."
United States
Lisa
The price is 2.799.907 ₫
4.102.346 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Portland Harbor Hotel
Aerial view
Hilton Garden Inn Portland Downtown Waterfront

Hilton Garden Inn Portland Downtown Waterfront

Hilton Garden Inn Portland Downtown Waterfront
3.0 star property
Old Port, 2.1 km from Maine Medical Center
9.2 out of 10, Wonderful, (1008)
"Great staff and a surprisingly great free breakfast."
United States
Paul
The price is 2.569.379 ₫
2.842.760 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hilton Garden Inn Portland Downtown Waterfront
Exterior
Holiday Inn Portland-By the Bay by IHG

Holiday Inn Portland-By the Bay by IHG

Holiday Inn Portland-By the Bay by IHG
4.0 star property
Portland Arts District, 1.2 km from Maine Medical Center
9.0 out of 10, Wonderful, (1432)
"Every thing was perfect, service, accomodations, and friendly staff!!!"
United States
Michael
The price is 2.053.818 ₫
2.272.343 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Portland-By the Bay by IHG
Free daily on-the-go breakfast
La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med

La Quinta Inn & Suites by Wyndham Portland DT/Maine Med
3.0 star property
0.6 km from Maine Medical Center
8.8 out of 10, Excellent, (2285)
"Great breakfast options and very convenient location."
United States
Greta
The price is 2.106.480 ₫
2.330.610 ₫ total
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Portland DT/Maine Med
Tapas bar
AC Hotel Portland Downtown/Waterfront, ME

AC Hotel Portland Downtown/Waterfront, ME

AC Hotel Portland Downtown/Waterfront, ME
3.5 star property
East Bayside, 2.3 km from Maine Medical Center
9.2 out of 10, Wonderful, (1000)
"The amenities and location "
United States
Michael
The price is 2.290.797 ₫
2.534.537 ₫ total
includes taxes & fees
22 Dec - 23 Dec
AC Hotel Portland Downtown/Waterfront, ME
Front of property – evening/night
Inn at St John Portland In-Town

Inn at St John Portland In-Town

Inn at St John Portland In-Town
2.5 star property
Valley Street, 0.3 km from Maine Medical Center
8.8 out of 10, Excellent, (1142)
"Friendly helpful staff and a nice independent location "
United States
Robert
The price is 2.106.480 ₫
2.296.063 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Inn at St John Portland In-Town
View from room
Hyatt Place Portland Downtown - Old Port Square

Hyatt Place Portland Downtown - Old Port Square

Hyatt Place Portland Downtown - Old Port Square
3.0 star property
Old Port, 1.6 km from Maine Medical Center
9.0 out of 10, Wonderful, (1293)
"Room was great, awesome location!"
United States
Erick
The price is 2.475.114 ₫
2.738.466 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Place Portland Downtown - Old Port Square
Breakfast, lunch, dinner served; American cuisine
The Westin Portland Harborview

The Westin Portland Harborview

The Westin Portland Harborview
4.0 star property
Downtown Portland, 0.9 km from Maine Medical Center
8.8 out of 10, Excellent, (1003)
"Helpful and friendly staff"
United States
Wei Chien
The price is 2.580.438 ₫
2.854.997 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
The Westin Portland Harborview
Bar (on property)
Aloft Portland Downtown Waterfront ME

Aloft Portland Downtown Waterfront ME

Aloft Portland Downtown Waterfront ME
3.0 star property
Downtown Portland, 1.4 km from Maine Medical Center
8.8 out of 10, Excellent, (1005)
"Clean, good breakfast and nice bar! "
United States
James
The price is 2.080.149 ₫
2.301.477 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Aloft Portland Downtown Waterfront ME
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Maine Medical Center Hotel Reviews

Hotels near other Maine Medical Center attractions

State Street Church

After visiting State Street Church, make a plan to see the other sights and activities in Portland. Stroll along the area's waterfront or experience its acclaimed theatre scene.
See properties

Portland Exposition Building

Learn about the events happening in Portland Exposition Building during your trip to Portland. Experience the area's entertainment choices and acclaimed theatre scene.
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Frequently asked questions

What's the area like around Maine Medical Center?
Maine Medical Center is located in a welcoming area of Portland known for its beautiful ocean views and sporting events. If you're looking for a convenient place to stay, take a look at the 191 hotels and other accommodation options you'll find within a mile.
How many hotels should I expect to find close to Maine Medical Center?
Expedia has 191 hotels and other accommodation options within a mile from Maine Medical Center.
If I need to cancel the hotel reservation for my stay near Maine Medical Center, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available near Maine Medical Center.
What can I see and do near Maine Medical Center?
International Cryptozoology Museum, Portland Museum of Art and Maine Narrow Gauge Railroad Company and Museum feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like State Theatre, Victoria Mansion and Portland Head Light. You can watch performances at Merrill Auditorium, Portland Stage and Port City Music Hall if you're interested in local theatre.