Medical Center District Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Downtown San Antonio

Downtown San Antonio

4 out of top 10 points of interest in this area
4.5/5(42 area reviews)

A scenic riverfront great entertainment and top sights from Alamodome to Aztec Theater – discover Downtown San Antonio, a destination also famous for its historic sites.

Find hotels in Downtown San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is 2.104.718 ₫ per night from 28 May to 29 May
2.104.718 ₫
2.487.966 ₫ total
28 May - 29 May
includes taxes & fees
8.4/10 Very Good! (3,350 reviews)
Great stay in a great location

Reviewed on 11 May 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is 2.661.155 ₫ per night from 15 May to 16 May
2.661.155 ₫
3.162.299 ₫ total
15 May - 16 May
includes taxes & fees
8.6/10 Excellent! (1,062 reviews)
The hotel’s location is great. The reception staff was welcoming and friendly, and the rooms are always clean.

Reviewed on 11 May 2026

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is 2.578.282 ₫ per night from 18 May to 19 May
2.578.282 ₫
3.047.762 ₫ total
18 May - 19 May
includes taxes & fees
8.8/10 Excellent! (1,009 reviews)
When I checked for a week and payed CASH IN TOWN FOR A MILITARY EVENT AT LACKLAND AFB DRIVE 25 hours, NO ONE INFORMED ME IF I HAD TO LEAVE EARLY I NEED TO GIVE A NOTICE OR THE HOTEL WOULD RETAIN A FEE OF 129.00. It just not a way to handle playing customers of over 25 years!

Reviewed on 8 May 2026

Courtyard by Marriott Medical Center San Antonio
See all 4,894 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Medical Centre District holiday package cost?
Starting from just , a holiday package is your passport to low-priced travel. Create your own Medical Centre District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Centre District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Centre District holiday package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your holiday your own way. We offer over 550 airlines and 1null000null000 properties throughout the world, so that everyone has a chance to travel and fulfil those holiday dreams.
Where should I stay in Medical Centre District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Centre District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Centre are two of the most well-known hotels in Medical Centre District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Centre District holiday?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Centre District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Centre District holiday.
What should I know before booking a Medical Centre District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Centre District Expedia holiday package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Centre District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Centre District holiday package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Centre District holiday package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Popular places to visit

River Walk

River Walk

5/5(21 reviews)

River Walk is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and shops in this walkable area.

River Walk
San Antonio Zoo and Aquarium

San Antonio Zoo and Aquarium

Why not visit the animals who live at San Antonio Zoo and Aquarium and see why this is a favourite sight in San Antonio? Experience the acclaimed theatre scene and lively festivals in this walkable area.

San Antonio Zoo and Aquarium
The Alamodome

Alamodome

Catch an event at Alamodome during your trip to San Antonio. Experience the acclaimed theatre scene and fascinating museums in this walkable area.

Alamodome