
Medical Center District Holidays
Book a Hotel + Flight or Car together to unlock savings
Where to stay in Medical Center District
Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District

Downtown San Antonio
4 out of top 10 points of interest in this area
4.5/5(42 area reviews)
A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.
Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is 2.339.436 ₫ per night from 12 Sept to 13 Sept
2.339.436 ₫
2.765.171 ₫ total
12 Sept - 13 Sept
includes taxes & fees
8.4/10 Very Good! (2,728 reviews)
"Hotel was in a nice area with lots of dining options nearby."
Reviewed on 25 Aug 2025

San Antonio Marriott Northwest Medical Center
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is 2.440.864 ₫ per night from 14 Sept to 15 Sept
2.440.864 ₫
2.900.601 ₫ total
14 Sept - 15 Sept
includes taxes & fees
8.4/10 Very Good! (1,015 reviews)
"It was a comfortable and pleasant experience."
Reviewed on 25 Aug 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
7203 Wurzbach Road, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is 2.423.740 ₫ per night from 21 Sept to 22 Sept
2.423.740 ₫
2.829.716 ₫ total
21 Sept - 22 Sept
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Popular places to visit

River Walk
River Walk is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and shops in this walkable area.

Alamodome
Catch an event at Alamodome during your trip to San Antonio. Experience the entertainment choices and great live music in this walkable area.

Alamo
Alamo is a top museum in San Antonio with a rich history. Experience the fascinating museums and lively festivals in this walkable area.