The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Our top choices for Medical Center District hotels

A modern kitchen with a large window, wooden counter, and two bar stools.

1. Park Inn by Radisson, Medical Center

Medical Center District

Amanda

1.918.102 ₫ total

includes taxes & fees

10 Sept - 11 Sept

A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.

2. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District

Melissa

2.737.146 ₫ total

includes taxes & fees

1 Sept - 2 Sept

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

3. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District

Melissa

2.774.080 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

4. Courtyard by Marriott Medical Center San Antonio

Medical Center District

Daniel

3.021.002 ₫ total

includes taxes & fees

8 Sept - 9 Sept

A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

5. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Medical Center District

Matthew

2.632.975 ₫ total

includes taxes & fees

6 Sept - 7 Sept

A spacious lobby with a central staircase, seating area, and large windows.

6. San Antonio Marriott Northwest Medical Center

Medical Center District

Mario

3.559.791 ₫ total

includes taxes & fees

1 Oct - 2 Oct

A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

7. OYO Inn & Suites Medical Center San Antonio

Medical Center District

Ronnie

A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

8. Studio 6 San Antonio, Tx - Northwest Medical Center

Medical Center District

Ruben

1.428.031 ₫ total

includes taxes & fees

1 Oct - 2 Oct

A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

9. Atria Inn & Suites

Medical Center District

José

1.852.034 ₫ total

includes taxes & fees

1 Sept - 2 Sept

A modern bedroom with a large bed, bedside tables, a desk, and a chair.

10. Motel 6 San Antonio, TX - Northwest Medical Center

Medical Center District

Rachel

1.650.998 ₫ total

includes taxes & fees

10 Sept - 11 Sept

A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

11. Flex Studios

Medical Center District

Jasper

1.220.731 ₫ total

includes taxes & fees

1 Sept - 2 Sept

A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Medical Center District

Jose

A modern lobby with a sofa, patterned chairs, a central ottoman, and a chandelier.

13. Drury Plaza Hotel San Antonio Airport

9 km from Medical Center District

Harry

3.513.917 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A modern hotel with a prominent signage for Springhill Suites by Marriott, featuring a multi-story structure with a flat roof and a covered entrance area.

14. SpringHill Suites by Marriott San Antonio Medical Center/NW

2.7 km from Medical Center District

Michael

3.112.149 ₫ total

includes taxes & fees

3 Sept - 4 Sept

A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

15. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Uptown, 9.3 km from Medical Center District

Victor M.

2.465.935 ₫ total

includes taxes & fees

2 Sept - 3 Sept

A modern kitchen with a central island, built-in appliances, and a coffee station.

16. Wyndham Garden San Antonio Airport

Uptown, 9.2 km from Medical Center District

Michelle

2.571.781 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A multi-level hotel atrium with a central courtyard, outdoor seating, and a pool.

17. Estancia del Norte San Antonio, Tapestry Collection by Hilton

8.5 km from Medical Center District

Kaybby

4.271.942 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A spacious living area with a dark blue sofa, four grey armchairs, and three metallic coffee tables.

18. La Quinta Inn & Suites by Wyndham San Antonio Airport

Shearer Hills - Ridgeview, 9.3 km from Medical Center District

Roland

2.441.423 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

19. Hyatt Place San Antonio-Northwest/Medical Center

3.7 km from Medical Center District

Monty

2.898.683 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A poolside area with lounge chairs and a metal railing.

20. Holiday Inn Express San Antonio-Airport by IHG

8.9 km from Medical Center District

Xiloneen

2.990.174 ₫ total

includes taxes & fees

20 Sept - 21 Sept

View all properties

Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,436 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,061 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,006 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,161 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,613 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

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A large, abstract sculpture with a flowing design, set against a dramatic sky.

Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

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A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Dub Farris Athletic Complex are top sights worth seeing.

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A field of bluebonnets under a vibrant sunset sky.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

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Top Medical Center District Hotel Reviews

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

10/10 Excellent

"Staff very helpful"

Signia by Hilton La Cantera Resort & Spa

8/10 Good

"We thoroughly enjoyed our stay! The staff and valet were top-notch, and the shuttle service was super convenient for getting around town. The pool and views were amazing. Upgrading to the top-floor adults-only level was totally worth it—the exclusive lounge with daily snacks and complimentary drinks made the trip extra special. The room itself had a few small flaws—a firm mattress, no bathroom vent fan, and a weak shower head—but the outstanding service and amenities far outweighed those details. We’d gladly stay here again!"

Omni La Mansion del Rio

10/10 Excellent

"We had a wonderful stay at this hotel! From the moment we arrived, the staff was incredibly friendly, welcoming, and helpful. Everyone went out of their way to make sure we felt comfortable and taken care of throughout our stay. The hotel was clean, comfortable, and had a great atmosphere. What really stood out was the kindness and professionalism of the staff they truly made our experience feel special. We really enjoyed our stay and would happily come back again. Highly recommend!"

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

10/10 Excellent

"This was the perfect place to stay while we were in San Antonio for our daughter's Air Force graduation. We were 8 miles from base, the traffic in the morning wasn't terrible at all! The property itself was very nice! We had stayed in a 2-bedroom so we could have the living room and space for family to gather. The pools & lazy river were wonderful!"

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

8/10 Good

"The hotel is located in a good area. It’s close enough to River Walk and also the Convention Center. Breakfast is what you would expect for a free breakfast. Want something different, Dennys is across the street. My only suggestion to the hotel would be to get larger pool towels. They were small and looked like cleaning towels. You needed 2-3 just to dry off."

Drury Inn & Suites San Antonio Northwest Medical Center

10/10 Excellent

"Very clean, staff was always kind and helpful from the front desk to the ones preparing food and any maintenance workers we encountered. The evening food and drink was a nice amenity which most places don’t offer. We always stay here when we come to San Antonio."

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.

How many hotels will I be able to find in Medical Center District?

Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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Our top choices for Medical Center District hotels

1. Park Inn by Radisson, Medical Center

2. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3. Drury Inn & Suites San Antonio Northwest Medical Center

4. Courtyard by Marriott Medical Center San Antonio

5. Fairfield Inn & Suites by Marriott San Antonio Medical Center

6. San Antonio Marriott Northwest Medical Center

7. OYO Inn & Suites Medical Center San Antonio

8. Studio 6 San Antonio, Tx - Northwest Medical Center

9. Atria Inn & Suites

10. Motel 6 San Antonio, TX - Northwest Medical Center

11. Flex Studios

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

13. Drury Plaza Hotel San Antonio Airport

14. SpringHill Suites by Marriott San Antonio Medical Center/NW

15. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

16. Wyndham Garden San Antonio Airport

17. Estancia del Norte San Antonio, Tapestry Collection by Hilton

18. La Quinta Inn & Suites by Wyndham San Antonio Airport

19. Hyatt Place San Antonio-Northwest/Medical Center

20. Holiday Inn Express San Antonio-Airport by IHG

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Uptown

Far West Side

Northwest Side

Stone Oak

Top Medical Center District Hotel Reviews

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Frequently asked questions

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