Search Hotels in Medical Center District, San Antonio

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Our top choices for Medical Center District hotels

San Antonio Marriott Northwest Medical Center

3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1006)
"The room is clean and the hotel staff are all nice including the staff from the restourant"
United States
Frank Charles
The price is 2.346.218 ₫
2.788.204 ₫ total
includes taxes & fees
11 Dec - 12 Dec
San Antonio Marriott Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1294)
"Great place to stay and visit "
United States
Harry
The price is 2.372.316 ₫
2.804.126 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Drury Inn & Suites San Antonio Northwest Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1004)
"Staff was super nice! "
United States
Fredric
The price is 2.188.046 ₫
2.554.544 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Park Inn by Radisson

2.0 star property
Medical Center District
7.2 out of 10, Good, (1008)
"Staff were amazing, and everything else was great too. "
United States
Maximilian
The price is 1.658.170 ₫
1.935.914 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Park Inn by Radisson

SpringHill Suites by Marriott San Antonio Medical Center/NW

3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1007)
"good staff. good stay"
United States
Divya
The price is 2.662.562 ₫
3.147.359 ₫ total
includes taxes & fees
14 Dec - 15 Dec
SpringHill Suites by Marriott San Antonio Medical Center/NW

Courtyard by Marriott Medical Center San Antonio

3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1007)
"Room was clean, staff was very friendly!!"
United States
Ray
The price is 2.346.218 ₫
2.773.441 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Courtyard by Marriott Medical Center San Antonio

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

3.0 star property
Medical Center District
6.8 out of 10, (1000)
"Easy check in"
United States
Violet
The price is 1.546.131 ₫
1.805.108 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Studio 6 San Antonio, Tx - Northwest Medical Center

2.0 star property
Medical Center District
7.2 out of 10, Good, (212)
"Its was comfy, didnt have any troubles and had sooo many shopping stops around and dinning places"
United States
Heaven
The price is 1.396.922 ₫
1.631.017 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Studio 6 San Antonio, Tx - Northwest Medical Center

Atria Inn & Suites

2.0 star property
Medical Center District
7.6 out of 10, Good, (272)
"😊"
United States
John Paul
Atria Inn & Suites

Motel 6 San Antonio, TX - Northwest Medical Center

2.0 star property
Medical Center District
6.0 out of 10, (1000)
"Really enjoyed our stay"
United States
ernest
The price is 1.126.976 ₫
1.332.186 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Motel 6 San Antonio, TX - Northwest Medical Center

Studio 6 San Antonio, TX - Medical Center

2.0 star property
Medical Center District
6.6 out of 10, (786)
"Clean room staff is really good real friendly I love being there"
United States
Matthew
The price is 1.224.152 ₫
1.499.782 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Studio 6 San Antonio, TX - Medical Center

OYO Inn & Suites Medical Center San Antonio

2.0 star property
Medical Center District
7.2 out of 10, Good, (224)
"Always great stay"
United States
Juan
The price is 1.423.548 ₫
1.846.527 ₫ total
includes taxes & fees
23 Dec - 24 Dec
OYO Inn & Suites Medical Center San Antonio

Flex Studios

2.5 star property
Medical Center District
6.0 out of 10, (497)
"heb is nearby. "
United States
Sayeed
The price is 1.091.387 ₫
1.290.117 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Flex Studios

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1277)
"Great place!"
United States
Heath
The price is 1.994.361 ₫
3.446.306 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Courtyard by Marriott San Antonio SeaWorld - Westover Hills

3.0 star property
Far West Side, 12.1 km from Medical Center District
8.6 out of 10, Excellent, (1086)
"It was clean and quiet and the staff was as always amazing"
United States
Chastity
The price is 2.442.439 ₫
2.902.473 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Courtyard by Marriott San Antonio SeaWorld - Westover Hills

La Quinta Inn & Suites by Wyndham San Antonio Northwest

3.0 star property
Far West Side, 10.4 km from Medical Center District
8.8 out of 10, Excellent, (1007)
"Friendly staff, clean rooms, convenient location. "
United States
Eduardo
The price is 2.128.732 ₫
2.485.294 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham San Antonio Northwest

La Quinta Inn & Suites By Wyndham San Antonio At The Rim

3.0 star property
11.9 km from Medical Center District
9.2 out of 10, Wonderful, (807)
"Great place to stay!! "
United States
Stacy
The price is 2.375.216 ₫
2.773.065 ₫ total
includes taxes & fees
16 Dec - 17 Dec
La Quinta Inn & Suites By Wyndham San Antonio At The Rim

Menger Hotel

3.5 star property
Downtown San Antonio, 12.6 km from Medical Center District
9.0 out of 10, Wonderful, (3562)
"Historic and classy, and you can beat the location."
United States
Warren
The price is 2.471.437 ₫
2.921.461 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Menger Hotel

Hotel Valencia Riverwalk

4.5 star property
Downtown San Antonio, 12.1 km from Medical Center District
9.4 out of 10, Exceptional, (2224)
"Beautful hotel would definitely recommend "
United States
Christina Ashley
The price is 2.507.820 ₫
3.717.660 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hotel Valencia Riverwalk

Riverwalk Plaza

4.0 star property
12.3 km from Medical Center District
8.2 out of 10, Very good, (6161)
"Nice hotel "
United States
Gabriel
Riverwalk Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Aztec Theater to San Antonio River – discover Downtown San Antonio, a destination also famous for its historic sites.

Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

Top Medical Center District Hotel Reviews

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Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.
How many hotels will I be able to find in Medical Center District?
Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.