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Our top choices for Medical Center District hotels

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1000)
"Staff was super nice! "
United States
Fredric
The price is 2.187.631 ₫
2.554.059 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Fairfield Inn & Suites by Marriott San Antonio Medical Center

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3107)
"quite place with good breakfast"
United States
Juan
The price is 2.340.502 ₫
2.766.431 ₫ total
includes taxes & fees
12 Dec - 13 Dec
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1001)
"Room was clean, staff was very friendly!!"
United States
Ray
The price is 2.345.773 ₫
2.772.915 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Courtyard by Marriott Medical Center San Antonio

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1000)
"The room is clean and the hotel staff are all nice including the staff from the restourant"
United States
Frank Charles
The price is 2.345.773 ₫
2.787.675 ₫ total
includes taxes & fees
12 Dec - 13 Dec
San Antonio Marriott Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1287)
"Great place to stay and visit "
United States
Harry
The price is 2.371.866 ₫
2.803.594 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Drury Inn & Suites San Antonio Northwest Medical Center

SpringHill Suites by Marriott San Antonio Medical Center/NW

SpringHill Suites by Marriott San Antonio Medical Center/NW
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1000)
"good staff. good stay"
United States
Divya
The price is 2.662.057 ₫
3.146.762 ₫ total
includes taxes & fees
14 Dec - 15 Dec
SpringHill Suites by Marriott San Antonio Medical Center/NW

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.6 out of 10, Good, (273)
"😊"
United States
John Paul
Atria Inn & Suites

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
6.8 out of 10, (1000)
"Easy check in"
United States
Violet
The price is 1.545.838 ₫
1.804.766 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.2 out of 10, Good, (225)
"Always great stay"
United States
Juan
The price is 1.411.615 ₫
1.832.560 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
OYO Inn & Suites Medical Center San Antonio

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.2 out of 10, Good, (213)
"Its was comfy, didnt have any troubles and had sooo many shopping stops around and dinning places"
United States
Heaven
The price is 1.396.657 ₫
1.630.597 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Studio 6 San Antonio, Tx - Northwest Medical Center

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1002)
"Staff were amazing, and everything else was great too. "
United States
Maximilian
The price is 1.657.855 ₫
1.935.546 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Park Inn by Radisson

Studio 6 San Antonio, TX - Medical Center

Studio 6 San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.6 out of 10, (787)
"Staff and amenities "
United States
Keyshia
The price is 1.223.920 ₫
1.499.498 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Studio 6 San Antonio, TX - Medical Center

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.0 out of 10, (497)
"heb is nearby. "
United States
Sayeed
The price is 1.091.180 ₫
1.289.874 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Flex Studios

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (999)
"Really enjoyed our stay"
United States
ernest
The price is 1.126.762 ₫
1.331.934 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 San Antonio, TX - Northwest Medical Center

La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
3.0 star property
9 km from Medical Center District
9.2 out of 10, Wonderful, (1119)
"Excellent rooms and friendly staff"
United States
alice
The price is 2.229.802 ₫
2.603.294 ₫ total
includes taxes & fees
18 Dec - 19 Dec
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
3.5 star property
Far West Side, 11.3 km from Medical Center District
9.0 out of 10, Wonderful, (1283)
"Great place!"
United States
Heath
The price is 1.772.064 ₫
3.183.821 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB

Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB
2.5 star property
7.7 km from Medical Center District
8.4 out of 10, Very good, (991)
"Excelente "
Mexico
María Montserrat
The price is 1.546.601 ₫
1.805.656 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Ramada by Wyndham San Antonio Near SeaWorld/Lackland AFB

Courtyard by Marriott San Antonio SeaWorld - Westover Hills

Courtyard by Marriott San Antonio SeaWorld - Westover Hills
3.0 star property
Far West Side, 12.1 km from Medical Center District
8.6 out of 10, Excellent, (1086)
"It was clean and quiet and the staff was as always amazing"
United States
Chastity
The price is 2.441.976 ₫
2.901.922 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott San Antonio SeaWorld - Westover Hills

Hilton San Antonio Hill Country

Hilton San Antonio Hill Country
4.0 star property
Far West Side, 11.6 km from Medical Center District
8.4 out of 10, Very good, (1043)
"Very nice property and service. "
United States
Rashied
The price is 2.571.916 ₫
3.930.048 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton San Antonio Hill Country

Home2 Suites by Hilton San Antonio Lackland/Sea World, TX

Home2 Suites by Hilton San Antonio Lackland/Sea World, TX
3.0 star property
Far West Side, 11.1 km from Medical Center District
8.8 out of 10, Excellent, (749)
"Clean room and good breakfast! Also service staff was great!"
United States
Darrel
The price is 2.403.758 ₫
2.935.173 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Home2 Suites by Hilton San Antonio Lackland/Sea World, TX
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Aztec Theater to San Antonio River – discover Downtown San Antonio, a destination also famous for its historic sites.

Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

Top Medical Center District Hotel Reviews

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Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.
How many hotels will I be able to find in Medical Center District?
Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.