What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.

How many hotels will I be able to find in Medical Center District?

Expedia has 123 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

USAA Corporate Office Headquarters, Cinemark San Antonio 16 and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

The Best Hotels in Medical Center District, San Antonio - 2025 Updated Prices

Top Trending Hotels Near Medical Center District, San Antonio

"Great stay "

2.747.853 ₫ total

includes taxes & fees

6 Jul - 7 Jul

"Awesome stay. "

2.961.611 ₫ total

includes taxes & fees

4 Aug - 5 Aug

"Nice stay overall"

3.094.214 ₫ total

includes taxes & fees

10 Jul - 11 Jul

"Staff very friendly, property clean and the breakfast was unbelievable i have not ever been to a hotel were breakfast has such a huge selection awesome I will be returning "

2.811.994 ₫ total

includes taxes & fees

13 Jul - 14 Jul

"Love it "

2.054.096 ₫ total

includes taxes & fees

20 Jul - 21 Jul

"Very nice place to stay."

3.032.817 ₫ total

includes taxes & fees

28 Jul - 29 Jul

Premium bedding, pillow-top beds, in-room safe, desk

"Very clean and accomodating."

3.375.737 ₫ total

includes taxes & fees

6 Jul - 7 Jul

"I like that the staff is extremely kind and the "

1.512.975 ₫ total

includes taxes & fees

5 Aug - 6 Aug

"Quick check in and great breakfast"

2.209.161 ₫ total

includes taxes & fees

17 Jul - 18 Jul

"It was very clean and nice and quiet."

1.279.678 ₫ total

includes taxes & fees

5 Aug - 6 Aug

Desk, laptop workspace, blackout curtains, free WiFi

"The location was convenient and the price was very good. "

1.485.157 ₫ total

includes taxes & fees

6 Jul - 7 Jul

Room, 2 Queen Beds | 1 bedroom, desk, iron/ironing board, Internet

"Beautiful place to stay love it "

2.140.360 ₫ total

includes taxes & fees

6 Jul - 7 Jul

Basic Room, Multiple Beds, Non Smoking | 1 bedroom, desk, iron/ironing board, free WiFi

"Great central location in the medical center area, with easy and convenient highway access. "

1.672.691 ₫ total

includes taxes & fees

5 Aug - 6 Aug

1 bedroom, desk, laptop workspace, free WiFi

"Good location for medical visit."

1.578.872 ₫ total

includes taxes & fees

7 Jul - 8 Jul

"Close to shopping areas, front staff were really friendly and room was really clean "

1.773.144 ₫ total

includes taxes & fees

3 Aug - 4 Aug

"nice hotel in a great location, just in the Alamo and River walk"

3.509.723 ₫ total

includes taxes & fees

29 Jul - 30 Jul

"Nice safe place to spend the night while traveling through Texas. "

2.537.463 ₫ total

includes taxes & fees

3 Aug - 4 Aug

"Would definitely stay there again"

2.857.535 ₫ total

includes taxes & fees

13 Jul - 14 Jul

"Very happy with my stay "

2.572.058 ₫ total

includes taxes & fees

13 Jul - 14 Jul

"Good place to stay"

2.867.251 ₫ total

includes taxes & fees

7 Jul - 8 Jul

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown - Riverwalk showing a river or creek, a bridge and boating

Downtown San Antonio

A scenic riverfront great entertainment and top sights from San Antonio River to Alamo – discover Downtown San Antonio, a destination also famous for its historic sites.

See properties