What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.

How many hotels will I be able to find in Medical Center District?

Expedia has 119 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

USAA Corporate Office Headquarters, Cinemark San Antonio 16 and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

The Best Hotels in Medical Center District, San Antonio - 2025 Updated Prices

Top Trending Hotels Near Medical Center District, San Antonio

Our top choices for Medical Center District hotels

"Eveyrhing excelent the staff great they give us a great welcome and the hotel is in excellent condition"

2.824.024 ₫ total

includes taxes & fees

31 Aug - 1 Sept

"A nice stay for the price. "

2.759.609 ₫ total

includes taxes & fees

21 Aug - 22 Aug

"Very nice place to stay."

3.045.792 ₫ total

includes taxes & fees

2 Sept - 3 Sept

"Great location and has complimentary private parking. "

3.107.451 ₫ total

includes taxes & fees

1 Sept - 2 Sept

"The staff was very friendly."

"We recommend this hotel 😊"

2.780.800 ₫ total

includes taxes & fees

31 Aug - 1 Sept

Premium bedding, pillow-top beds, in-room safe, desk

"Friendly staff , clean room and great shopping options walking distance "

3.232.338 ₫ total

includes taxes & fees

2 Sept - 3 Sept

Desk, laptop workspace, blackout curtains, free WiFi

"The location was convenient and the price was very good. "

1.439.750 ₫ total

includes taxes & fees

27 Aug - 28 Aug

"Beautiful place to stay love it "

1.867.915 ₫ total

includes taxes & fees

2 Sept - 3 Sept

"Love it "

1.920.336 ₫ total

includes taxes & fees

2 Sept - 3 Sept

"Really enjoyed our stay"

1.428.970 ₫ total

includes taxes & fees

2 Sept - 3 Sept

"Quick check in and great breakfast"

2.184.223 ₫ total

includes taxes & fees

22 Aug - 23 Aug

Basic Room, Multiple Beds, Non Smoking | 1 bedroom, desk, iron/ironing board, free WiFi

"Great central location in the medical center area, with easy and convenient highway access. "

1.415.360 ₫ total

includes taxes & fees

21 Aug - 22 Aug

1 bedroom, desk, laptop workspace, free WiFi

"Everything perfect"

1.604.863 ₫ total

includes taxes & fees

18 Sept - 19 Sept

Premium bedding, down duvets, individually decorated

"The room was beyond comfortable, with a great mattress, and everything was spotless. The hotel offered a very pleasant and peaceful stay"

2.546.374 ₫ total

includes taxes & fees

25 Aug - 26 Aug

"Great stay. "

2.729.991 ₫ total

includes taxes & fees

2 Sept - 3 Sept

"Great place"

1.154.004 ₫ total

includes taxes & fees

7 Sept - 8 Sept

"Super nice place to stay - safe, quiet, and the staff was amazing! "

"This place is awesome, close to restaurants that you can walk too, very quiet and clean they make you feel welcomed from the start, will definitely stay here again next time im in san antonio. "

1.629.183 ₫ total

includes taxes & fees

28 Aug - 29 Aug

"We enjoyed our stay here"

1.956.557 ₫ total

includes taxes & fees

2 Sept - 3 Sept

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown - Riverwalk showing a river or creek, a bridge and boating

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

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