Search Hotels in Otay Mesa, San Diego

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,727 reviews)
"Very clean. Staff was very friendly. Breakfast buffet was very complete and with variety of food."
United States
Eliza
The price is 3.294.500 ₫
3.747.560 ₫ total
includes taxes & fees
31 May - 1 Jun
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,006 reviews)
"The only hotel in otay mesa and overall the service was good"
United States
MARIA
The price is 2.562.594 ₫
2.914.951 ₫ total
includes taxes & fees
31 May - 1 Jun
Quality Suites San Diego Otay Mesa

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
29.9 km from Otay Mesa
8.4 out of 10, Very good, (1,858 reviews)
"Staff are great. Awesome location. Good breakfast, heated pool. Would stay again!"
United States
Kent
The price is 2.820.092 ₫
3.235.990 ₫ total
includes taxes & fees
31 May - 1 Jun
Best Western Yacht Harbor Hotel

Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
13.7 km from Otay Mesa
9.4 out of 10, Exceptional, (1,003 reviews)
"Room was great, very clean. Staff was so friendly and helpful. Other visitors were great conversation over breakfast. Tons of places to eat walking distance and super close to the beach. For the price it was incredible. Will be returning soon. "
United States
Isabel
The price is 3.562.013 ₫
4.067.640 ₫ total
includes taxes & fees
10 May - 11 May
Hampton Inn & Suites Imperial Beach San Diego

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,517 reviews)
"Great stay and family friendly "
United States
Gregory
The price is 4.085.180 ₫
6.028.796 ₫ total
includes taxes & fees
13 May - 14 May
Sheraton San Diego Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,890 reviews)
"Amazing rooms and casino "
United States
Bryan
The price is 2.598.702 ₫
3.174.844 ₫ total
includes taxes & fees
6 May - 7 May
Sycuan Casino Resort

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very good, (377 reviews)
"Great room. Staff was friendly. Easy access to trolley and free parking made getting around super easy. "
United States
Jason
The price is 2.296.135 ₫
2.639.292 ₫ total
includes taxes & fees
10 May - 11 May
Best Western San Diego Pacific Beach/Mission Bay

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,658 reviews)
"The staff is always polite. Always friendly and welcoming. Way different place to visit then it was years ago. It's clean and pleasant. "
United States
wes
The price is 2.060.776 ₫
2.270.833 ₫ total
includes taxes & fees
18 May - 19 May
Motel 6 El Cajon, CA - San Diego

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,061 reviews)
"It was clean and convenient to the airport."
United States
Joey L
The price is 3.716.196 ₫
4.271.582 ₫ total
includes taxes & fees
10 May - 11 May
Holiday Inn Express San Diego Airport - Old Town by IHG

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (640 reviews)
"Clean and spacious room. Amazing outdoor pool/jacuzzi with outdoor seating and a nice fire pit. The bartender Mico is THEE BEST! "
United States
Shatera
The price is 5.192.132 ₫
5.721.471 ₫ total
includes taxes & fees
17 May - 18 May
SpringHill Suites by Marriott Chula Vista Eastlake

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,267 reviews)
"Basic beach motel. Served its purpose. Its old and dingy but it was quiet and safe. Manager was very nice. "
United States
Karin
The price is 2.967.422 ₫
3.345.768 ₫ total
includes taxes & fees
5 May - 6 May
Ocean Villa Inn

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,629 reviews)
"This hotel is one of a kind. The pool area is stunning. Restaurants are great. Hip, busy scene at the bars and restaurants, yet quiet and cozy in your stylish room. The design of everything is over the top-- it was a treat to stay here. We'll be back."
United States
Kelly
The price is 6.562.644 ₫
7.543.431 ₫ total
includes taxes & fees
6 May - 7 May
Lafayette Hotel & Club

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,638 reviews)
"The price was cheaper on Expedia than walking in. The staff was nice. The room was clean. More than enough room for parking. I would get a room there again."
United States
Hanna
The price is 2.029.412 ₫
2.312.313 ₫ total
includes taxes & fees
5 May - 6 May
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,808 reviews)
"The room was clean, staff was really friendly and helpful, there is plenty of parking spots. I would definitely stay again in this hotel "
United States
Jessica
The price is 4.190.604 ₫
4.617.835 ₫ total
includes taxes & fees
10 May - 11 May
Best Western Plus Marina Gateway Hotel

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,224 reviews)
"Room was clean hotel was close to beach & restaurant "
United States
Andrea
The price is 2.872.804 ₫
3.302.145 ₫ total
includes taxes & fees
5 May - 6 May
Wyndham Garden San Diego Near SeaWorld

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.8 out of 10, Good, (1,008 reviews)
"Very nice place very clean"
United States
Hugo
The price is 2.329.870 ₫
2.567.338 ₫ total
includes taxes & fees
7 May - 8 May
Days Inn by Wyndham San Diego-East/El Cajon

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3,565 reviews)
"Room was very clean, staff was friendly and location was amazing!!"
United States
Erica
The price is 4.010.065 ₫
4.609.369 ₫ total
includes taxes & fees
5 May - 6 May
Bay Club Hotel & Marina

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,437 reviews)
"Staff were very friendly and accommodating The resort was beautiful and location was amazing"
United States
Valerie
The price is 5.771.964 ₫
8.028.301 ₫ total
includes taxes & fees
10 May - 11 May
San Diego Mission Bay Resort

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,127 reviews)
"Location was fairly convenient to most attractions. The staff was awesome. Breakfast was good. The fact that we didn't have to pay for parking was one of the reasons we chose this hotel compared to others in the San Diego area."
United States
Melissa
The price is 3.405.195 ₫
3.745.715 ₫ total
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego South - Chula Vista by IHG

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,268 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
United States
Nicole
The price is 3.223.866 ₫
3.667.147 ₫ total
includes taxes & fees
10 May - 11 May
Best Western Americana Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.