Photo by Mike McClain

Find hotels in Puxico, MO from 1.476.534 ₫

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Our top choices for Puxico hotels

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (332)
"Room was nice and spacious."
United States
Rebecca
The price is 1.776.262 ₫
1.994.529 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Dexter Inn

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (252)
"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "
United States
Michelle
The price is 1.565.479 ₫
1.757.845 ₫ total
includes taxes & fees
20 Jan - 21 Jan 2026
Econo Lodge Dexter

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (387)
"Very nice"
United States
Dennis
The price is 2.032.834 ₫
2.282.628 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Travelodge by Wyndham Dexter

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (131)
"Excellent experience overall. The rooms were neat and hygienic, with all basic amenities available. Staff was courteous and quick to assist. Check-in and check-out were smooth. The location is convenient and safe. Great value for money. Highly recommended for both business and leisure stays"
United States
Amber
The price is 1.174.175 ₫
1.476.534 ₫ total
includes taxes & fees
20 Jan - 21 Jan 2026
OYO Hickory House Inn

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (4)
"Staff was helpful and professional. The rooms were clean and comfortable "
United States
Michael
The price is 2.722.024 ₫
3.056.506 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Hampton Inn By Hilton Dexter

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (84)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (968)
"Nice room helpful staff. "
United States
Deborah
The price is 2.789.127 ₫
3.150.695 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Drury Inn & Suites Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
United States
Teresa
The price is 2.728.865 ₫
3.082.936 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very good, (212)
"Had to "
United States
Brenda
Bullwinkles Rustic Lodge

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is 2.965.174 ₫
3.320.254 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn Poplar Bluff

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (625)
"The lady at the front was very nice. "
United States
Travis
The price is 1.498.639 ₫
1.693.086 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Super 8 by Wyndham Poplar Bluff Missouri

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (400)
"it was a nice stay, room was a little warm, thermostat may need changing out. Other than that it was great. "
United States
Jim
The price is 2.431.506 ₫
2.746.993 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn Poplar Bluff North

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (705)
"Amazing place"
United States
Mladen
The price is 2.894.650 ₫
3.270.231 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Holiday Inn Poplar Bluff by IHG

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1004)
"Love the updated rooms and the vending area."
United States
Kathi
The price is 1.999.940 ₫
2.109.410 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Motel 6 Poplar Bluff, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

More cheap stays in Puxico

Frequently asked questions

What's the seasonal weather in Puxico?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Puxico is 1502 mm.

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