Sanctuary Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. Learn more about Sanctuary
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Mid Island

2 out of top 10 points of interest in this area

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

Find hotels in Mid Island

Top hotels in Sanctuary

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
The price is 9.460.130 ₫ per night from 19 Apr to 20 Apr
9.460.130 ₫
per night
19 Apr - 20 Apr
9/10 Wonderful! (1,964 reviews)
Newly constructed, pristine hotel. I was most worried about the valet but it was super easy. Note they do add resort fees and valet fees at check out. I would stay here again! Pool and beach area are great!!

Reviewed on 26 Mar 2026

Margaritaville Beach Resort Fort Myers
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
The price is 8.403.736 ₫ per night from 26 Apr to 27 Apr
8.403.736 ₫
per night
26 Apr - 27 Apr
9.2/10 Wonderful! (1,728 reviews)
Amazing room, good food, nice staff

Reviewed on 26 Mar 2026

Sanibel Island Beach Resort
Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

3.5 out of 5
1400 Estero Blvd Fort Myers Beach FL
Fully refundableReserve now, pay when you stay
The price is 6.296.216 ₫ per night from 27 Apr to 28 Apr
6.296.216 ₫
per night
27 Apr - 28 Apr
9/10 Wonderful! (1,332 reviews)
Would go back, great location and amenities! Not the most well maintained hotel, it's older but has a lot of positives that outweigh the negatives. Pool was very warm and the view from our room was 10/10! Restaurant food was sub par but the street food was delicious, especially the taco place!

Reviewed on 27 Mar 2026

Lani Kai Beachfront Resort
See all 13,104 properties in Sanctuary
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Sanctuary holiday package cost?
Starting from as little as , you can tailor your Sanctuary package the way you want. Simply combine hotels, flights and car rentals and we'll reward you with discounts.
How do I get a cheap travel package to Sanctuary?
Booking a flight and hotel together with Expedia won't just save you time — it'll save you a pretty penny too. A Sanctuary holiday package makes it easy to organise your dream adventure. With more than 550 airlines across the world to choose from, finding convenient flights that suit your schedule won't be hard. On top of that, we've got over 1null000null000 properties globally to select from. Now that's what we call choice. No matter who you are, Expedia brings the world within your reach.
Where should I stay in Sanctuary?
A getaway to Sanctuary wouldn't be complete without seeing Bowmans Beach, Blind Pass Beach and Castaways Marina. Spend your evenings close to these top attractions and make sightseeing a breeze.
How far in advance should I book my Sanctuary holiday?
Reward yourself with the biggest variety at the lowest prices by booking your holiday to Sanctuary early. Airlines typically release flight tickets around 12 months prior to departure, so start your planning ASAP. That said, Expedia is committed to providing you with the best deals around, so it's never a bad time to book your dream holiday!
What does an Expedia Sanctuary travel package include?
That depends on what you're after. If you're travelling by yourself, you might decide to bundle flights and hotels. Taking the whole family to Sanctuary? A travel package that includes hotels, rental cars and flights might suit you better. Expedia gives you the freedom and flexibility to tailor-make your travel package.
What should I know before booking a Sanctuary travel package?
Booking all the parts of your escape together is a terrific way to save. Bundle your car rentals, airfares and hotels into one package. But you're not limited to hotels. Expedia offers all types of properties, including holiday rentals like beachfront villas and spacious residences. The list goes on!
Can I choose my airline with a Sanctuary Expedia holiday package?
Most definitely. Expedia has over 550 partner airlines to choose from globally. With so much choice, finding the perfect carrier to whisk you away to Sanctuary won't be difficult.
If I'm not able to travel, can I cancel my Sanctuary holiday package?
Don't stress if you're rethinking your Sanctuary holiday package — it's possible to change or amend your booking. And if you've booked it within the last 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We totally understand life can sometimes throw you a curveball, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we'll be here to help.

Popular places to visit

Sanibel Island Lighthouse

Sanibel Island Lighthouse

4/5(23 reviews)

You can find out about the history of Sanibel with a trip to Sanibel Island Lighthouse. Wander through the beautiful beaches and seaside in this family-friendly area.

Sanibel Island Lighthouse
Bowman's Beach

Bowman's Beach

4.5/5(5 reviews)

Why not spend a care-free afternoon at Bowman's Beach during your travels in Sanibel? Stroll along the seaside or discover the area's sunsets.

Bowman's Beach
Periwinkle Way

Periwinkle Way

During your trip to Sanibel, you can do some window-shopping at Periwinkle Way. Wander the beautiful beaches in this relaxing area.

Periwinkle Way