Santa Ana Holidays

Book a Hotel + Flight or Car together to unlock savings

Top hotels in Santa Ana

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
The price is 2.041.975 ₫ per night from 15 Dec to 16 Dec
2.041.975 ₫
2.491.209 ₫ total
15 Dec - 16 Dec
includes taxes & fees
9/10 Wonderful! (3,096 reviews)
Great hotel, had refried black beens, plantains and bacon all in the same plate, awesome. If one chooses the premier room, it includes the breakfast buffet, also bottle water available

Reviewed on 19 Nov 2025

Barceló Guatemala City
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez
Fully refundableReserve now, pay when you stay
The price is 7.381.360 ₫ per night from 25 Dec to 26 Dec
7.381.360 ₫
9.326.876 ₫ total
25 Dec - 26 Dec
includes taxes & fees
9.2/10 Wonderful! (1,008 reviews)
Room was spotless, staff was awesome. Great venue. This hotel never disappoints!!

Reviewed on 21 Nov 2025

Hotel Museo Spa Casa Santo Domingo
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4 out of 5
1a Avenida 12-46 Zona 10 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
The price is 2.306.675 ₫ per night from 26 Dec to 27 Dec
2.306.675 ₫
2.814.144 ₫ total
26 Dec - 27 Dec
includes taxes & fees
9/10 Wonderful! (1,597 reviews)
clean, great staff!

Reviewed on 22 Nov 2025

Wyndham Garden Guatemala City
See all 1,230 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana holiday package cost?
You can pick up a holiday package to this destination on Expedia. However, how much your holiday to Santa Ana costs will depend on the season, hotel choice and length of stay.
What are the cheapest months to go to Santa Ana?
If you'd like to snag a cheap Santa Ana holiday package, consider visiting in June, September and October. You'll usually find better prices on accommodation and flights during these months — perfect for a budget-friendly break.
How many days is enough for Santa Ana?
Generally, a handful of days is enough to tick off the main attractions during your Santa Ana holiday. However, if you'd like to have time to relax or go on day trips, consider extending your itinerary.
How to find the best Santa Ana package deals?
Begin your search for a Santa Ana package deal by entering your destination and preferred trip dates under our "Packages" tab. Then apply some filters, like "Property type" and "Popular locations," to tailor the results to your exact style. You can also sort by "Package discount" and discover offers that come with unbeatable savings. If you don't find the ideal Santa Ana package deal straight away, just play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Ana adventure underway.
Is it cheaper to book a Santa Ana holiday as a package?
An Expedia holiday package could land you great savings when compared to arranging hotels and flights individually. Better still, you can customise your Santa Ana trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a holiday package to Santa Ana?
If you're considering a spontaneous Santa Ana trip, check out our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Ana?

  1. Pick your travel dates: What you'd like to do in Santa Ana and your preferred season can help you decide when to travel.
  2. Work out your budget: Make sure you have enough money to cover everything from meals and transportation to flights and activities. Your hotel will probably be the largest expense during your trip to Santa Ana.
  3. Decide how long to go for: Now that you're more familiar with Santa Ana, you can work out the ideal length of your break. Create a rough plan and give yourself enough time to get through everything on your must-do list.
  4. Bundle your accommodation and airfare: After you've nailed down your trip dates and duration, book the perfect Santa Ana holiday package for you.

Popular places to visit

Casa Santo Domingo Museum

Casa Santo Domingo Museum

5/5(1 review)

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this family-friendly area.

Casa Santo Domingo Museum
Antigua Guatemala Cathedral

Antigua Guatemala Cathedral

5/5(4 reviews)

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints or seek out its local tours.

Antigua Guatemala Cathedral
Santa Catalina Arch

Santa Catalina Arch

4.5/5(2 reviews)

Find out about the history of Antigua Guatemala when you spend time at Santa Catalina Arch. Discover the volcano viewpoints and shops in this romantic area.

Santa Catalina Arch