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Our top choices for Santa Cruz hotels

Hotel Casa Miranda

Hotel Casa Miranda
2.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (4)
"La atencion es excelente, no asi las instalaciones. El salir de la habitacion para el baño y que este tapado no es muy buena experiencia. Le falta identificacion en la parte de afuera, son aspectos a mejorar "
Mexico
FERNANDO
The price is 1.120.491 ₫
1.338.994 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hotel Casa Miranda

Mesón de San Andrés

Mesón de San Andrés
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (115)
"Love it! "
United States
EFREN
The price is 1.434.053 ₫
1.713.692 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Mesón de San Andrés

Dos Patios Querétaro Curamoria Collection

Dos Patios Querétaro Curamoria Collection
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (128)
"Spacious and clean room. Great service from Valet employees. "
United States
Alfredo
The price is 2.700.718 ₫
3.227.358 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Dos Patios Querétaro Curamoria Collection

Casa Realm

Casa Realm
3.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (28)
"Great location 👌 "
United States
Crispin
The price is 1.225.685 ₫
1.464.694 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Casa Realm

Cinco de Mayo Hotel

Cinco de Mayo Hotel
2.5 star property
Santa Cruz
7.6 out of 10, Good, (309)
"Kind of an unbeatable location in the historic center of Queretaro. Simple, clean, decent value. "
United States
Shaun
The price is 689.602 ₫
824.074 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Cinco de Mayo Hotel

Casa Brunella Hotel Boutique

Casa Brunella Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (233)
"Unique boutique hotel with eccentric decor and spacious room. Centrally located "
United States
Elsa
The price is 2.114.300 ₫
2.526.582 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Casa Brunella Hotel Boutique

Hotel Úrsula Concept

Hotel Úrsula Concept
3.0 star property
Santa Cruz
8.6 out of 10, Excellent, (14)
"It is very clean, the bed was great and all in an historic home that has been converted to a charming family run boutique quality hotel. It is very close to an historic church with its huge plaza filled with families and activities and comfortable benches."
United States
Steven
The price is 2.206.239 ₫
2.636.449 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Úrsula Concept

Hotel Suites Sofia

Hotel Suites Sofia
3.0 star property
Santa Cruz
8.4 out of 10, Very good, (46)
"Perfect place for our needs"
United States
Joseph
The price is 1.830.866 ₫
2.187.885 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Hotel Suites Sofia

Hotel Boutique Casa Altamira

Hotel Boutique Casa Altamira
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (358)
"Very nice boutique hotel in one of the city center’s main dinning zones. The rooms are new and clean, the parking is good and the neighborhood is pretty"
United States
Ulises
Hotel Boutique Casa Altamira

Hotel Meson de Isabel

Hotel Meson de Isabel
3.0 star property
Santa Cruz
7.4 out of 10, Good, (59)
"Good place but for the price definitely not worth it"
United States
Manuel
Hotel Meson de Isabel

Hotel & Spa La Mansión del Burro Azul

Hotel & Spa La Mansión del Burro Azul
3.5 star property
Santa Cruz
8.4 out of 10, Very good, (442)
"The place is absolutely beautiful and original. "
United States
Martha
The price is 1.265.488 ₫
1.512.258 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel & Spa La Mansión del Burro Azul

Hotel Casa Once

Hotel Casa Once
3.5 star property
Centro Histórico, 0.5 km from Santa Cruz
9.6 out of 10, Exceptional, (287)
"Amazing hotel "
United States
lizette
The price is 2.304.286 ₫
2.753.625 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hotel Casa Once

Hotel Patio Santiago

Hotel Patio Santiago
4.5 star property
Centro Histórico, 0.6 km from Santa Cruz
9.4 out of 10, Exceptional, (405)
"Staff was pleasant, rooms were clean and modern, and it was in a walkable area. It’s a beautiful and relatively new hotel, and a very relaxed stay,"
United States
Alondra
The price is 3.427.384 ₫
4.095.724 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Hotel Patio Santiago

La Casa del Atrio

La Casa del Atrio
3.5 star property
Centro Histórico, 1.1 km from Santa Cruz
9.6 out of 10, Exceptional, (474)
"Charming hotel in a historic old building right in the center of town. The staff was super helpful and courteous. We loved our stay."
United States
Prabuddha
The price is 2.214.550 ₫
2.646.387 ₫ total
includes taxes & fees
25 Dec - 26 Dec
La Casa del Atrio

4Play Motel

4Play Motel
3.0 star property
13.6 km from Santa Cruz
8.6 out of 10, Excellent, (10)
"Perfect room for couples super clean and comfortable "
United States
Josue Rocky
The price is 1.164.432 ₫
1.391.504 ₫ total
includes taxes & fees
25 Dec - 26 Dec
4Play Motel

Hotel Estancias VIVE MX el marques Queretaro, Trademark

Hotel Estancias VIVE MX el marques Queretaro, Trademark
3.0 star property
4.2 km from Santa Cruz
9.6 out of 10, Exceptional, (68)
"We stayed here to catch an early flight from QRO International Airport, and it was a great choice. The staff was very friendly, the facilities were clean and well-kept, and getting an Uber to the airport was quick and easy. The only thing to note is that the elevators are on the smaller side, but I was still able to fit two large suitcases without a problem."
United States
Mishel
The price is 1.171.755 ₫
1.400.247 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hotel Estancias VIVE MX el marques Queretaro, Trademark

Quinta Allende

Quinta Allende
3.5 star property
Centro Histórico, 1.1 km from Santa Cruz
9.2 out of 10, Wonderful, (366)
"Very nice, quiet hotel with doves cooing in the morning."
United States
Eric John
Quinta Allende

The Latit Hotel Querétaro

The Latit Hotel Querétaro
3.5 star property
15.5 km from Santa Cruz
8.2 out of 10, Very good, (579)
"Very good service."
United States
J Santos
The Latit Hotel Querétaro

Hotel Mamá Carlota

Hotel Mamá Carlota
3.5 star property
Centro Histórico, 0.9 km from Santa Cruz
8.8 out of 10, Excellent, (355)
"Everything was good! The only thing there’s no breakfast. "
United States
MARIANA
The price is 1.401.712 ₫
1.675.053 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Mamá Carlota

La Casa de la Marquesa

La Casa de la Marquesa
4.0 star property
Centro Histórico, 1 km from Santa Cruz
8.8 out of 10, Excellent, (559)
"Unbelievable place to stay Love it "
United States
maribel
The price is 2.985.376 ₫
3.567.524 ₫ total
includes taxes & fees
29 Dec - 30 Dec
La Casa de la Marquesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Downtown Querétaro

Downtown Querétaro is known for its ample dining options, and you can make a stop by Zenea Garden and Plaza de Armas while in the area.

Centro Histórico

Unique features of Centro Histórico include the historical sites and museums. Make a stop by Zenea Garden or Plaza de Armas while you're exploring the area.

Juriquilla

Juriquilla is noteworthy for its restaurants, and you can make a stop at top attractions like Plaza Juriquilla and Plaza Ubika.

Jurica

Jurica is noteworthy for its shopping, and you can make a stop at top attractions like Antea Lifestyle Center and Urban Center Shopping Mall.

Downtown Tequisquiapan

You'll enjoy the monuments and shopping in Downtown Tequisquiapan. You might want to make time for a stop at Tequisquiapan Handicraft Market or La Pila Park.

Top Santa Cruz Hotel Reviews

Frequently asked questions

What is Santa Cruz like?
Travellers to Querétaro's Santa Cruz neighbourhood will be sure to enjoy a stay here. Are you looking for Santa Cruz travel tips? Make sure that you visit Aqueduct of Santiago de Querétaro and Templo y Convento de la Santa Cruz while you're in the neighbourhood.
How many hotels are there in the Santa Cruz area?
Expedia has 45 hotels and other accommodation options in Santa Cruz to choose from, making this an ideal home base for exploring the greater Querétaro area.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best options available in Santa Cruz.
What is there to do around this Querétaro neighbourhood?
Explore Santa Cruz's landmarks such as Aqueduct of Santiago de Querétaro, Templo y Convento de la Santa Cruz and Arches Viewpoint and learn about the local history. You could also plan a visit to Convent and Temple of Santa Cruz or Querétaro Contemporary Art Museum while you're in the neighbourhood. Plaza de Los Fundadores, Casa de la Zacatecana Museum and Ignacio Mena Rosales House of Culture are just a few of the places to visit in and around Santa Cruz. Plaza de Armas and Querétaro Regional Museum are also worth a visit when you're out sightseeing in Querétaro.