The Best Hotels in Santo Spirito, Florence - 2026 Updated Prices

A grand church interior with high vaulted ceilings, large columns, and a central altar.

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Our top choices for Santo Spirito hotels

A spacious living room with a large grey sofa, yellow armchairs, and a chandelier.

1. Hotel Horto Convento

Santo Spirito

adelio

5.627.071 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A hotel room with a bed, a table, and chairs outside the window.

2. La Fonderia Firenze

Santo Spirito

Kate

3.242.822 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A hotel room with a bed, a table with a plate of food, a bottle of wine, and a chair. There is a window with curtains, a radiator, and a wall-mounted TV.

3. 1900 Artevita

Santo Spirito

Selena

2.252.360 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A restaurant with multiple tables and chairs, a bar area, and large windows allowing natural light.

4. UNA Hotels Vittoria Firenze

Santo Spirito

Glenn

2.870.029 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A spacious living room with a fireplace, a chandelier, and a bar area.

5. AdAstra Suites

Santo Spirito

Peter

12.736.018 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A view through an open window of a cityscape with historic architecture, including domed buildings and a prominent tower.

6. Torre di Bellosguardo

Santo Spirito

Brad

16.640.133 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A spacious bedroom with a large bed, a clawfoot bathtub, a television, and a chandelier.

7. Oltrarno Splendid

Santo Spirito

Carin

10.793.700 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A narrow cobblestone street with a parked white scooter and a table with chairs in the background.

8. Drom Florence Rooms & Apartments

Santo Spirito

Else Marie

5.499.884 ₫ total

includes taxes & fees

13 Sept - 14 Sept

A cozy reading nook with a fireplace, bookshelves, and comfortable seating.

9. Ottantotto Firenze

Santo Spirito

Timothy

6.945.538 ₫ total

includes taxes & fees

30 Aug - 31 Aug

10. La Torre Del Cestello

Santo Spirito

Mersiha

3.243.988 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A grand hallway with a high ceiling, large wooden doors, and classical columns.

11. Casa Santo Nome di Gesù

Santo Spirito

Rebecca

3.920.539 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A building entrance with a large arched doorway, a potted plant, and pink flowers in the foreground.

12. Residenza D'Epoca Al Numero 8

Santo Spirito

Laura Patricia

7.842.798 ₫ total

includes taxes & fees

12 Sept - 13 Sept

A buffet setup with various food items, baskets, and serving utensils.

13. Home in Florence

Santo Spirito

Victoria

900.888 ₫ total

includes taxes & fees

9 Sept - 10 Sept

A modern living room with a teal sofa, a beige armchair, and a dining area with a table and chairs.

14. Mamo Florence - Aleardi Roof Apartment

Santo Spirito

Roberto Carlos

9.903.718 ₫ total

includes taxes & fees

13 Sept - 14 Sept

A modern living room with a wooden dining table, blue sofa, and a black metal shelving unit with plants.

15. Appartamenti degli Artisti by Mmega

Santo Spirito

Juliet

4.972.085 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A gravel pathway leading to a building with a balcony, surrounded by lush greenery and various plants.

16. Palazzo D'Oltrarno - Residenza D'Epoca

Santo Spirito

Diane

5.135.747 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A bedroom with a bed, pillows, a chair, and a fireplace.

17. B&B Mia Palace

Santo Spirito

Wayne

4.056.259 ₫ total

includes taxes & fees

7 Sept - 8 Sept

A covered courtyard with columns, a bench, and potted plants.

18. Foresteria Valdese di Firenze - Casa per Ferie

Santo Spirito

Alloura

2.738.340 ₫ total

includes taxes & fees

31 Aug - 1 Sept

A building with a large arched entrance, a sign for 'Monte dei Paschi di Siena', and two parked cars on the street.

19. L'Antica Porta Boutique B&B

Santo Spirito

Victor

3.921.113 ₫ total

includes taxes & fees

30 Aug - 31 Aug

A balcony with terracotta tiles, a metal table, and potted plants.

20. Campuccio Terrace by Mmega

Santo Spirito

Anonymous traveller

5.285.326 ₫ total

includes taxes & fees

30 Aug - 31 Aug

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Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

A river with buildings on the right bank.

Historic Centre of Florence

Cathedral of Santa Maria del Fiore and Piazza di Santa Maria Novella are a few top attractions in Historic Centre of Florence. Hop around the city on the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop and check out the area's fascinating museums, stunning cathedral and stunning river views.

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A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.

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A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

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A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing.

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An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

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Top Santo Spirito Hotel Reviews

Hotel Horto Convento

10/10 Excellent

"Everybody on staff was extremely helpful!"

Foresteria Valdese di Firenze - Casa per Ferie

8/10 Good

"There was a fridge and AC in the room which was nice. Check-in desk was friendly, we actually checked in like an hour early and when checking out we checked out 15 minutes late, not charged and were able to drop our bags with a bathroom available in the lobby. The area felt safe at night and there was nothing to complain about. There were larger recycling and trash available on the second floor outside the rooms which was useful to not have so much trash accumulate. There did end up being some ants in the bathroom, we weren't sure where they came from. Did not end up telling staff, wasn't a huge issue or a lot of ants. The last thing was just that Florence's public transport was slightly confusing but we figured it out eventually."

Ottantotto Firenze

8/10 Good

"We had a lovely stay here. The room was very clean and beautifully decorated. The bed was extremely comfortable and the shower was large and powerful. Even though our room was facing the street, there was very little road noise. The out of hours check in process was quite easy - they provide you with a door code and your room card is in a lock box inside the hallway. Breakfast was simple but good and the receptionist was very friendly. The lift is a bit slow but at least there is one! We would definitely stay here again."

Frequently asked questions

What is Santo Spirito like?

Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Piazza Santo Spirito and Santo Spirito Basilica as part of your Santo Spirito travel plans.

How many hotels can I expect to find in the Santo Spirito area?

Expedia has 500 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.

If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?

Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.

What can I see and do in this Florence neighbourhood?

Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Piazza Santo Spirito and Santo Spirito Basilica are some other places worth a visit. Piazza di Santa Maria Novella and Cathedral of Santa Maria del Fiore are some popular places to visit in the area around Santo Spirito. When you're sightseeing in Florence, Piazza del Carmine and Santa Maria della Carmine are also worth a stop.

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Our top choices for Santo Spirito hotels

1. Hotel Horto Convento

2. La Fonderia Firenze

3. 1900 Artevita

4. UNA Hotels Vittoria Firenze

5. AdAstra Suites

6. Torre di Bellosguardo

7. Oltrarno Splendid

8. Drom Florence Rooms & Apartments

9. Ottantotto Firenze

10. La Torre Del Cestello

11. Casa Santo Nome di Gesù

12. Residenza D'Epoca Al Numero 8

13. Home in Florence

14. Mamo Florence - Aleardi Roof Apartment

15. Appartamenti degli Artisti by Mmega

16. Palazzo D'Oltrarno - Residenza D'Epoca

17. B&B Mia Palace

18. Foresteria Valdese di Firenze - Casa per Ferie

19. L'Antica Porta Boutique B&B

20. Campuccio Terrace by Mmega

Where to stay in Santo Spirito

Historic Centre of Florence

Duomo

Santa Maria Novella

San Giovanni

Santa Croce

Top Santo Spirito Hotel Reviews

Hotel Horto Convento

Frequently asked questions

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