Search Hotels in South Main, Houston
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,289 reviews)
"Hotel clean and convenient "
Mitzi
The price is 2.369.790 ₫
2.772.654 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,014 reviews)
"Great location"
Jeremy
The price is 2.080.149 ₫
2.433.776 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,014 reviews)
"Close and convenient to NRG."
Cynthia
The price is 2.376.373 ₫
2.780.356 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (850 reviews)
"Room was clean. It had a musty smell though. "
Ryan
The price is 2.053.818 ₫
2.402.967 ₫ total
includes taxes & fees
20 Apr - 21 Apr
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,006 reviews)
"Courteous staff, clean room, quite property"
Javier
The price is 1.660.170 ₫
1.942.400 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.2 out of 10, Very good, (142 reviews)
"Nice place "
Ramon
The price is 1.599.371 ₫
1.871.265 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (165 reviews)
"Nice place to stay"
Bella
The price is 2.879.295 ₫
3.469.837 ₫ total
includes taxes & fees
13 Apr - 14 Apr
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (24 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is 2.132.811 ₫
2.495.388 ₫ total
includes taxes & fees
13 Apr - 14 Apr
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (213 reviews)
"Yes very great place"
Lloyd
The price is 2.346.355 ₫
2.745.236 ₫ total
includes taxes & fees
5 May - 6 May
Crystal Inn - NorthWest - 290
Crystal Inn - NorthWest - 29024.8 km from South Main
9.8 out of 10, Exceptional, (48 reviews)
"The staff were very nice everything was clean inside and out. "
Tyisha
The price is 2.627.307 ₫
3.021.403 ₫ total
includes taxes & fees
13 Apr - 14 Apr
Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (856 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
Travis
The price is 2.027.487 ₫
2.372.161 ₫ total
includes taxes & fees
25 Apr - 26 Apr
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.6 out of 10, Exceptional, (31 reviews)
"loveeeee. so cute came here for spring break. comfy little spot definitely recommend!"
Danielle
The price is 2.343.459 ₫
2.741.847 ₫ total
includes taxes & fees
13 Apr - 14 Apr
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Clean and courteous staff."
chris
The price is 2.246.034 ₫
2.627.860 ₫ total
includes taxes & fees
10 May - 11 May
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,837 reviews)
"Clean room and courteous staff. "
Sarah
The price is 2.595.183 ₫
3.052.454 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,200 reviews)
"Enjoyed my stay!"
Chelsea Renee
The price is 3.334.821 ₫
3.901.740 ₫ total
includes taxes & fees
3 May - 4 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,802 reviews)
"The staff was very helpful and made our stay enjoyable."
cynthia
The price is 2.394.804 ₫
2.801.921 ₫ total
includes taxes & fees
23 Apr - 24 Apr
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (774 reviews)
"Everything about this place was awesome. Will definitely be staying there again on my next trip!!!!!"
Penny
The price is 2.103.584 ₫
2.377.050 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,142 reviews)
"Great breakfast and staff was wonderful."
Jeffery
The price is 2.215.754 ₫
2.548.116 ₫ total
includes taxes & fees
13 Apr - 14 Apr
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,717 reviews)
"wonderful stay "
Stepfan
The price is 2.775.287 ₫
3.247.087 ₫ total
includes taxes & fees
8 May - 9 May
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (1,879 reviews)
"Very clean property, staff was helpful"
Elton
The price is 2.615.458 ₫
3.090.631 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,014 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 850 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,289 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,014 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,006 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
10/10 Excellent
