Search Hotels in South Main, Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,288 reviews)
"Would stay again!"
Austin
The price is 2.607.264 ₫
3.050.499 ₫ total
includes taxes & fees
29 May - 30 May
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,004 reviews)
"Good parking"
joseph
The price is 1.976.517 ₫
2.312.524 ₫ total
includes taxes & fees
4 Jun - 5 Jun
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,005 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is 2.534.577 ₫
2.965.454 ₫ total
includes taxes & fees
31 May - 1 Jun
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is 1.977.192 ₫
2.313.314 ₫ total
includes taxes & fees
30 May - 31 May
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (865 reviews)
"My stay was perfect "
Fredrick
The price is 2.186.635 ₫
2.558.363 ₫ total
includes taxes & fees
1 Jun - 2 Jun
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (84 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
Cruz
The price is 2.123.208 ₫
2.484.011 ₫ total
includes taxes & fees
7 Jun - 8 Jun
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (258 reviews)
"Simply amazing stay "
Jesus
The price is 2.228.026 ₫
2.606.790 ₫ total
includes taxes & fees
31 May - 1 Jun
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,212 reviews)
"Wonderful place to stay!"
Lisa
The price is 3.111.598 ₫
3.640.570 ₫ total
includes taxes & fees
8 Jun - 9 Jun
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (1,936 reviews)
"Breakfast was wonderful and the front desk staff were very helpful."
Reta
The price is 3.397.344 ₫
4.005.444 ₫ total
includes taxes & fees
31 May - 1 Jun
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (174 reviews)
"It was very clean"
Jesus
The price is 2.880.826 ₫
3.471.684 ₫ total
includes taxes & fees
31 May - 1 Jun
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very good, (204 reviews)
"Great price and nice rooms"
Armando
The price is 1.777.417 ₫
2.079.579 ₫ total
includes taxes & fees
29 May - 30 May
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,908 reviews)
"Nice overnight stay. Great for close to airport!!!"
Jaime
The price is 2.517.985 ₫
2.961.654 ₫ total
includes taxes & fees
8 Jun - 9 Jun
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (67 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is 2.580.928 ₫
3.019.687 ₫ total
includes taxes & fees
29 May - 30 May
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"Parking was easy."
Chris
The price is 2.652.299 ₫
3.103.189 ₫ total
includes taxes & fees
8 Jun - 9 Jun
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (791 reviews)
"Everything was great"
Claudette
The price is 2.103.983 ₫
2.377.501 ₫ total
includes taxes & fees
11 Jun - 12 Jun
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (2,043 reviews)
"Clean convenient close to airport and food"
Brian
The price is 2.038.406 ₫
2.384.936 ₫ total
includes taxes & fees
2 Jun - 3 Jun
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is 2.580.928 ₫
3.019.685 ₫ total
includes taxes & fees
31 May - 1 Jun
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport31.2 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great option close to the airport! "
Lisa
The price is 2.354.716 ₫
2.755.019 ₫ total
includes taxes & fees
5 Jun - 6 Jun
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (40 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is 2.133.216 ₫
2.495.863 ₫ total
includes taxes & fees
30 May - 31 May
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,897 reviews)
"Great location and nice walking trail behind the property!"
michael
The price is 2.569.867 ₫
2.955.163 ₫ total
includes taxes & fees
31 May - 1 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,005 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 865 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,288 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,004 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
2/10 Terrible
