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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical Center
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center Hotel
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport
Hotel Royale
Hotel Royale
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar LandCompare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,005 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 865 reviews | View | ||||||
![]() Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,288 reviews | View | ||||||
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,004 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View |
Where to stay in South Main

Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews





























































































