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24 Aug - 25 Aug
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Top Trending Hotels Near South Main, Houston

Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center
Lobby

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1130)
"It was quiet and close to our event. It was very clean and staff was helpful "
The price is 3.400.182 ₫
3.978.213 ₫ total
includes taxes & fees
25 Aug - 26 Aug
Wyndham Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Gazebo

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (930)
"Great location, rooms were hot/warm. Needs a huge make over."
The price is 2.873.022 ₫
3.361.435 ₫ total
includes taxes & fees
25 Aug - 26 Aug
Wingate Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.4 out of 10, (1002)
"Wonderful experience absolutely love my stay"
The price is 1.802.360 ₫
2.108.762 ₫ total
includes taxes & fees
24 Sept - 25 Sept
Quality Inn & Suites NRG Park - Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (790)
"Will definitely be back again!"
The price is 1.950.492 ₫
2.282.076 ₫ total
includes taxes & fees
21 Sept - 22 Sept
Candlewood Suites Houston Medical Center by IHG
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers

Hyatt Regency Houston/Galleria

4.0 star property
9.0 out of 10, Wonderful, (1008)
"Great stay!"
The price is 3.338.241 ₫
3.936.316 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Hyatt Regency Houston/Galleria
Hyatt Place Houston Medical Center
Lobby

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1912)
"Nice place to stay."
The price is 3.110.244 ₫
3.658.273 ₫ total
includes taxes & fees
4 Sept - 5 Sept
Hyatt Place Houston Medical Center
Omni Houston Hotel
Interior

Omni Houston Hotel

4.0 star property
9.0 out of 10, Wonderful, (1007)
"Great place to stay Very relaxing out-of-the-way Great feel with a great swimming pool"
The price is 3.985.330 ₫
4.732.778 ₫ total
includes taxes & fees
6 Sept - 7 Sept
Omni Houston Hotel
Blossom Hotel Houston
Front of property

Blossom Hotel Houston

4.0 star property
9.0 out of 10, Wonderful, (3470)
"The hotel is wonderful and I loved it "
The price is 3.985.330 ₫
4.662.835 ₫ total
includes taxes & fees
22 Sept - 23 Sept
Blossom Hotel Houston
Hyatt Regency Houston West
Breakfast, lunch, brunch served; American cuisine, garden views

Hyatt Regency Houston West

3.5 star property
8.6 out of 10, Excellent, (1150)
"Nice rooms, plenty of food choices."
The price is 2.778.133 ₫
3.250.417 ₫ total
includes taxes & fees
28 Aug - 29 Aug
Hyatt Regency Houston West
Holiday Inn Express & Suites Houston – Downtown North by IHG
Exterior

Holiday Inn Express & Suites Houston – Downtown North by IHG

2.5 star property
9.2 out of 10, Wonderful, (557)
"Very clean with good breakfast! "
The price is 2.714.874 ₫
3.176.403 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Holiday Inn Express & Suites Houston – Downtown North by IHG
The Lancaster Hotel
Exterior

The Lancaster Hotel

4.0 star property
9.8 out of 10, Exceptional, (1003)
"Beautiful hotel with Ana amazing room! Really enjoyed our stay and the staff was excellent!"
The price is 6.618.494 ₫
7.743.639 ₫ total
includes taxes & fees
25 Aug - 26 Aug
The Lancaster Hotel
The Whitehall Houston
City view from property

The Whitehall Houston

4.0 star property
8.6 out of 10, Excellent, (1685)
"Great location and very friendly staff "
The price is 3.769.194 ₫
4.409.958 ₫ total
includes taxes & fees
31 Aug - 1 Sept
The Whitehall Houston
Hyatt House Houston Medical Center
Lobby

Hyatt House Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1086)
"We loved our stay. Great room, staff, and service."
The price is 3.297.386 ₫
3.878.316 ₫ total
includes taxes & fees
27 Aug - 28 Aug
Hyatt House Houston Medical Center
Haven Inn & Suites Downtown Houston
Premium bedding, desk, iron/ironing board, free WiFi

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1007)
"enjoyed stay "
Haven Inn & Suites Downtown Houston
La Quinta Inn & Suites by Wyndham Houston Southwest
Exterior

La Quinta Inn & Suites by Wyndham Houston Southwest

3.0 star property
6.8 out of 10, (1003)
"The stay here was amazing me and my kids are currently homeless and going from hotel to hotel and this was the perfect stay for us "
The price is 1.725.131 ₫
2.018.404 ₫ total
includes taxes & fees
1 Sept - 2 Sept
La Quinta Inn & Suites by Wyndham Houston Southwest
Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection
View from room

Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection

3.0 star property
7.8 out of 10, Good, (1002)
"What a great place to stay. Super clean rooms, super kind staff. "
The price is 3.024.581 ₫
3.538.761 ₫ total
includes taxes & fees
26 Aug - 27 Aug
Heights House Hotel - Houston Heights Downtown, Ascend Hotel Collection
The Royal Sonesta Houston Galleria
Exterior

The Royal Sonesta Houston Galleria

4.0 star property
8.4 out of 10, Very good, (1203)
"Overall decent hotel with a great location, lots of restaurants and attractions near the hotel"
The price is 2.890.155 ₫
4.059.938 ₫ total
includes taxes & fees
28 Aug - 29 Aug
The Royal Sonesta Houston Galleria
Club Quarters Hotel Downtown, Houston
Lobby

Club Quarters Hotel Downtown, Houston

4.0 star property
8.4 out of 10, Very good, (3629)
"Very nice place to stay and a great staff!"
The price is 2.767.590 ₫
3.238.080 ₫ total
includes taxes & fees
26 Aug - 27 Aug
Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Daily buffet breakfast for a fee

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
8.4 out of 10, Very good, (416)
"Great stay, shuttle to MD Anderson very convenient, they let us check out 1 hour later to accommodate Dr appt. "
The price is 3.036.442 ₫
3.552.638 ₫ total
includes taxes & fees
1 Sept - 2 Sept
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Sonesta ES Suites Houston Galleria
Lobby

Sonesta ES Suites Houston Galleria

3.0 star property
8.2 out of 10, Very good, (1085)
"We enjoyed our stay. The room was spacious and clean and breakfast was amazing. We highly recommend to stay in this hotel if you are visiting Houston. "
The price is 2.585.720 ₫
3.025.371 ₫ total
includes taxes & fees
6 Sept - 7 Sept
Sonesta ES Suites Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green showing city views, modern architecture and a high-rise building

Downtown Houston

3 out of top 10 points of interest in this area

Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

1 out of top 10 points of interest in this area

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Theater District

Restaurants and seafood restaurants are just a few things travellers like about Theater District. A stop by Wortham Center is also recommended if you've got time to explore the area.

Houston Heights

You'll enjoy the coffee shops and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 55 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.