Photo by Bill Dillard

Search Guest Houses in Southeast Missouri

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months
No exact matches found, but these alternatives could be just right

Recommended hotels in Southeast Missouri

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is 4.184.244 ₫
4.423.792 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Echo Bluff State Park

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (707)
"Amazing place"
United States
Mladen
The price is 2.759.610 ₫
3.117.571 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Poplar Bluff by IHG

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is 2.181.143 ₫
2.305.983 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Jackson MO

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is 2.365.117 ₫
2.667.886 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (859)
"The rooms were very clean and well maintained and th e staff was great and the young lady who checked us in was awsome at her job she helped me get the smart tv workin and has a very professional and respectfull through the hole stay we thank this is the nicest hotel i ve stayed at by far andcwill be back "
United States
Terry
The price is 2.733.328 ₫
3.087.977 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is 2.247.111 ₫
2.555.527 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
The Farmstead Hotel

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (968)
"Nice room helpful staff. "
United States
Deborah
The price is 2.759.347 ₫
3.117.308 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Drury Inn & Suites Poplar Bluff

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (543)
"lean, updated rooms, friendly staff and great breakfast."
United States
Linda
The price is 2.289.492 ₫
2.620.896 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites Perryville by IHG

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (477)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is 2.530.957 ₫
2.855.014 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The Riverview

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (334)
"Staff was very friendly."
United States
Joyce
The price is 2.365.117 ₫
2.564.072 ₫ total
includes taxes & fees
25 Jan - 26 Jan 2026
Honeysuckle Inn - Mountain View

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is 2.312.816 ₫
2.609.180 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1010)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is 1.990.542 ₫
2.268.719 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Best Western Plus Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is 2.365.117 ₫
2.719.136 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Drury Inn & Suites Sikeston, MO

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (797)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is 2.943.584 ₫
3.296.079 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn Poplar Bluff

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (723)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is 1.458.388 ₫
1.662.197 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (174)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is 3.153.840 ₫
3.444.782 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Fort Davidson Hotel

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
"Everything was wonderful- the family that owns this is very kind, and it’s in a beautiful location!"
United States
Nathan
Shepherd Mountain Inn

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is 3.285.250 ₫
3.722.648 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1002)
"Room was clean , staff was friendly !"
United States
Sally
The price is 1.389.485 ₫
1.581.930 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Baymont Inn and Suites by Wyndham Farmington, MO

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (451)
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is 2.567.915 ₫
2.907.520 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Southeast Missouri Hotel Reviews

Find out more about Southeast Missouri

Southeast Missouri Guest Houses information

Number of reviews
12,642
Accommodation
0 Guest Houses
Lowest Price
1.581.930 ₫
Highest Price
4.423.792 ₫