Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO

Sikeston

Janica

3.360.759 ₫ total

includes taxes & fees

1 Jun - 2 Jun

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Douglas

3.272.840 ₫ total

includes taxes & fees

8 Jun - 9 Jun

Hampton Inn Sikeston

Sikeston

Amanda

3.031.989 ₫ total

includes taxes & fees

14 Jun - 15 Jun

Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Candia

2.752.696 ₫ total

includes taxes & fees

4 Jun - 5 Jun

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Richard

2.970.773 ₫ total

includes taxes & fees

14 Jun - 15 Jun

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

Karen

3.268.298 ₫ total

includes taxes & fees

7 Jun - 8 Jun

Hampton Inn Poplar Bluff

Poplar Bluff

Tammy

2.857.456 ₫ total

includes taxes & fees

14 Jun - 15 Jun

Drury Inn & Suites Poplar Bluff

Poplar Bluff

Stephanie

2.796.493 ₫ total

includes taxes & fees

28 Jun - 29 Jun

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Jeff

2.640.722 ₫ total

includes taxes & fees

31 May - 1 Jun

The Riverview

Cape Girardeau

Audra

3.930.385 ₫ total

includes taxes & fees

31 May - 1 Jun

Drury Inn & Suites Jackson MO

Jackson

Jeremy

2.310.752 ₫ total

includes taxes & fees

8 Jun - 9 Jun

Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, desk, laptop workspace, blackout curtains

Super 8 by Wyndham Perryville

Perryville

Cynthia

2.126.951 ₫ total

includes taxes & fees

9 Jun - 10 Jun

Tru By Hilton Cape Girardeau

Cape Girardeau

Kendra

2.777.396 ₫ total

includes taxes & fees

18 Jun - 19 Jun

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Angela

3.280.084 ₫ total

includes taxes & fees

4 Jun - 5 Jun

Honeysuckle Inn - Mountain View

Mountain View

Daniel

2.723.406 ₫ total

includes taxes & fees

31 May - 1 Jun

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Mark

3.130.988 ₫ total

includes taxes & fees

21 Jun - 22 Jun

Premium bedding, down duvets, pillow-top beds, in-room safe

The Farmstead Hotel

Caruthersville

Michael

2.845.308 ₫ total

includes taxes & fees

30 May - 31 May

Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Wanda

3.142.797 ₫ total

includes taxes & fees

14 Jun - 15 Jun

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Youpeng

2.534.195 ₫ total

includes taxes & fees

10 Jun - 11 Jun

Best Western Plus Sikeston I-55

Sikeston

Tabitha

2.715.589 ₫ total

includes taxes & fees

28 Jun - 29 Jun

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Holiday Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Here is good accommodation! Next time, I hope I will stay here."

Cottage

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Aparthotel

The Atrium - A Boutique Hotel

Perryville

"Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would be to put variable light switches so you could turn down the lighting at night. I would definitely recommend and would stay here again on my next trip to Perryville."

Cottage

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

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Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

4.8/5 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Clearwater Lake.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"This was one of the nicest hotels I have ever stayed at, except for one thing. More on that in a minute. Pros: great indoor pool, plenty of room and warm water, plus a hot tub. Free breakfast. Usual offerings plus hot food bar. Menu changes daily and open until 9:30 / 10:00 so you can sleep in and still get hot food. Happy hour snacks and drinks. Again, hot food bar, menu different everyday, up to 3 free drinks per person per night (recommend the margaritas and cherry vodka sour!!). Great bed with lots of room, warm blankets, fluffy pillows, and crisp white sheets. Temp controlled room that actually stays at the temp you set it. Living room hide-a-bed is actually comfortable. All of the staff were friendly, and went out of their way to make you feel welcome. Parking is easy and abundant. Close to everything the Cape has to offer. Quiet. Reasonably priced for the quality that you are getting. Now for the single Con: the bathroom light is automatic. Great idea. Terrible execution. It comes on full blast in the middle of the night when you get up to use the restroom. Blinded at 3 am is not fun. Light actually turned OFF while I was taking a shower. Also, not fun. That's it, an excellent hotel that I will definitely recommend but take a nightlight and an eye mask."

Baymont Inn and Suites by Wyndham Farmington, MO

4/10 Poor

"The pool was not open and no one could tell me when it would be. They changed my room type without asking me and sold out of the room type I had booked. I was stuck with a Cheaper room with no composition for our stay. When I communicated this to the property I was told I should not have booked through third-party. The remodel job is lipstick on a pig. The walls are paper thin, so be prepared to hear the conversations of everyone in your hallway as well as the very loud staff whom live in the hotel."

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Hotel was pretty decent. Everything was clean and comfy. Only complaint I would make is that the walls are not very soundproof. The people in the room next to us had loud music and raised voices most of our first night. You couldn't understand what they were saying, but they were very loud. Otherwise, great stay."

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"We stayed for one night as a couple at the Drury Inn and had a really great experience. The beds were extremely comfortable and made for a great night’s sleep after a long day of traveling. The room was clean, well-kept, and felt fresh the moment we walked in. The staff was super friendly from check-in to check-out and made everything easy and welcoming. You can tell they really care about their guests. Breakfast was above average compared to most hotels — plenty of options, hot food, and everything was well stocked and organized. Overall, a solid, comfortable stay and we would definitely choose Drury Inn again when passing through the area."