Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from 1.507.599 ₫
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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,004 reviews)
The price is 2.922.478 ₫
3.360.119 ₫ total
includes taxes & fees
19 Apr - 20 Apr

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,008 reviews)
The price is 2.632.837 ₫
2.970.208 ₫ total
includes taxes & fees
19 Apr - 20 Apr

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (746 reviews)
The price is 2.346.092 ₫
2.539.098 ₫ total
includes taxes & fees
16 Apr - 17 Apr

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (534 reviews)
The price is 2.677.336 ₫
3.031.414 ₫ total
includes taxes & fees
3 May - 4 May

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (888 reviews)
The price is 2.764.755 ₫
3.123.481 ₫ total
includes taxes & fees
19 Apr - 20 Apr

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,005 reviews)
The price is 1.579.860 ₫
1.798.670 ₫ total
includes taxes & fees
20 Apr - 21 Apr

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,003 reviews)
The price is 2.764.755 ₫
3.119.031 ₫ total
includes taxes & fees
26 Apr - 27 Apr

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (173 reviews)
The price is 2.409.813 ₫
2.718.606 ₫ total
includes taxes & fees
27 Apr - 28 Apr

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
The price is 1.711.515 ₫
1.805.253 ₫ total
includes taxes & fees
14 Apr - 15 Apr

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,004 reviews)
The price is 1.895.569 ₫
2.138.468 ₫ total
includes taxes & fees
20 Apr - 21 Apr

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,007 reviews)
The price is 2.106.217 ₫
2.226.798 ₫ total
includes taxes & fees
20 Apr - 21 Apr

Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
8.4 out of 10, Very good, (1,002 reviews)
The price is 2.014.058 ₫
2.295.523 ₫ total
includes taxes & fees
19 Apr - 20 Apr

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (817 reviews)
The price is 2.461.422 ₫
2.756.177 ₫ total
includes taxes & fees
26 Apr - 27 Apr

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,011 reviews)
The price is 2.369.527 ₫
2.673.158 ₫ total
includes taxes & fees
3 May - 4 May

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,004 reviews)
The price is 2.501.182 ₫
2.825.711 ₫ total
includes taxes & fees
19 Apr - 20 Apr

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (536 reviews)
The price is 2.501.445 ₫
2.844.769 ₫ total
includes taxes & fees
20 Apr - 21 Apr

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (578 reviews)
The price is 2.659.431 ₫
3.044.390 ₫ total
includes taxes & fees
23 Apr - 24 Apr

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (71 reviews)
The price is 2.896.410 ₫
3.279.461 ₫ total
includes taxes & fees
26 Apr - 27 Apr

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very good, (959 reviews)
The price is 2.346.092 ₫
2.682.865 ₫ total
includes taxes & fees
26 Apr - 27 Apr

Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
7.0 out of 10, Good, (391 reviews)
The price is 1.468.217 ₫
1.603.660 ₫ total
includes taxes & fees
3 May - 4 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (59 reviews)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO
8/10 Good
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is 1.579.860 ₫ per night from 20 Apr to 21 Apr
1.579.860 ₫
1.798.670 ₫ total
20 Apr - 21 Apr
includes taxes & fees
8/10 Very Good! (1,005 reviews)
Hotels in Southeast Missouri with star rating

4 Star Hotels
2 properties

3 Star Hotels
60 properties




















































































































