
Find hotels in Southeast Missouri, MO from 1.478.307 ₫
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Our top choices for Southeast Missouri hotels

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
7.8 out of 10, Good, (1,007 reviews)
The price is 1.497.162 ₫
1.616.410 ₫ total
includes taxes & fees
19 Jan - 20 Jan

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,003 reviews)
The price is 2.363.677 ₫
2.717.480 ₫ total
includes taxes & fees
18 Jan - 19 Jan

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (470 reviews)
The price is 2.120.979 ₫
2.412.083 ₫ total
includes taxes & fees
14 Jan - 15 Jan

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (686 reviews)
The price is 2.210.284 ₫
2.392.080 ₫ total
includes taxes & fees
15 Jan - 16 Jan

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
The price is 2.363.677 ₫
2.666.261 ₫ total
includes taxes & fees
19 Jan - 20 Jan

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very good, (728 reviews)
The price is 1.457.500 ₫
1.661.185 ₫ total
includes taxes & fees
14 Jan - 15 Jan

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (864 reviews)
The price is 2.731.664 ₫
3.086.098 ₫ total
includes taxes & fees
31 Jan - 1 Feb

Best Western Plus Sikeston
Best Western Plus SikestonSikeston
8.4 out of 10, Very good, (1,009 reviews)
The price is 1.763.499 ₫
2.009.949 ₫ total
includes taxes & fees
18 Jan - 19 Jan

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (219 reviews)
The price is 4.307.624 ₫
4.554.236 ₫ total
includes taxes & fees
14 Jan - 15 Jan

Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
8.8 out of 10, Excellent, (711 reviews)
The price is 2.889.260 ₫
3.264.601 ₫ total
includes taxes & fees
17 Jan - 18 Jan


Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,003 reviews)
The price is 2.179.815 ₫
2.304.579 ₫ total
includes taxes & fees
14 Jan - 15 Jan

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (977 reviews)
The price is 2.495.292 ₫
2.819.189 ₫ total
includes taxes & fees
18 Jan - 19 Jan

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (336 reviews)
The price is 2.363.677 ₫
2.562.511 ₫ total
includes taxes & fees
25 Jan - 26 Jan

Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (445 reviews)
The price is 2.442.738 ₫
2.765.791 ₫ total
includes taxes & fees
25 Jan - 26 Jan

Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (175 reviews)
The price is 3.151.920 ₫
3.442.685 ₫ total
includes taxes & fees
14 Jan - 15 Jan

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (462 reviews)
The price is 2.643.410 ₫
2.993.001 ₫ total
includes taxes & fees
8 Feb - 9 Feb

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (578 reviews)
The price is 3.388.314 ₫
3.857.950 ₫ total
includes taxes & fees
14 Jan - 15 Jan

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,004 reviews)
The price is 1.407.858 ₫
1.602.846 ₫ total
includes taxes & fees
1 Feb - 2 Feb

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,001 reviews)
The price is 1.838.357 ₫
2.092.349 ₫ total
includes taxes & fees
20 Jan - 21 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Southeast Missouri, MO
Showing deals for:23 Jan - 25 Jan
Image gallery for Johnson's Shut-ins State Park

Johnson's Shut-ins State Park
Middle Brook
10/10Exceptional (1 review)
Member Price available
Price is 6.987.554 ₫
14.775.262 ₫ total
Total includes taxes and fees
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is 1.407.858 ₫ per night from 1 Feb to 2 Feb
1.407.858 ₫
1.602.846 ₫ total
1 Feb - 2 Feb
includes taxes & fees
7.8/10 Good! (1,001 reviews)
Hotels in Southeast Missouri with star rating

4 Star Hotels
1 properties

3 Star Hotels
51 properties



















































































