Midtown Travel Guide

St. Louis

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.
A sundae with chocolate ice cream and whipped cream.
A cathedral interior with Gothic architecture, including pointed arches and ribbed vaults.
A Gothic-style cathedral with intricate stonework, pointed arches, and statues.
A highway with multiple lanes, vehicles, and a bridge overhead.

Stay near popular Midtown attractions


Top hotels in Midtown

Element by Marriott St. Louis Midtown

Element by Marriott St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is 3.544.425 ₫ per night from 6 Aug to 7 Aug
3.544.425 ₫
4.144.460 ₫ total
6 Aug - 7 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (779 reviews)
"The property was nice in appearance. The staff were very helpful. The breakfast would benefit from more food. They ran out of different items before the close of breakfast. Our suite was humid even with the thermostat set to 68…just could not get humidity out of the room. The ac was a bit noisy also.There ..."

Reviewed on 14 Jul 2026

Element by Marriott St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is 3.098.090 ₫ per night from 4 Aug to 5 Aug
3.098.090 ₫
3.684.526 ₫ total
4 Aug - 5 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a 24-hour fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
7.8/10 Good! (1,011 reviews)
"Breakfast selection was good. We had a spot on floor in living room that was soaked from a condensation leak. Maintenance installed a huge industrial fan for drying so we weren't able to use the living room area"

Reviewed on 13 Jul 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is 3.520.795 ₫ per night from 19 Jul to 20 Jul
3.520.795 ₫
4.152.038 ₫ total
19 Jul - 20 Jul
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (4,248 reviews)
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Reviewed on 14 Jul 2026

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is 2.495.800 ₫ per night from 19 Jul to 20 Jul
2.495.800 ₫
2.913.517 ₫ total
19 Jul - 20 Jul
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
8.8/10 Excellent! (3,301 reviews)
"We had a string of negative experiences during our three-night stay. The first night, the air conditioner in the room was rattling very loudly. I called the front desk and they seemed very annoyed to be talking to me, but they offered to get us a new room. The keys they gave us for the new room didn't ..."

Reviewed on 13 Jul 2026

Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is 3.412.887 ₫ per night from 19 Jul to 20 Jul
3.412.887 ₫
4.365.225 ₫ total
19 Jul - 20 Jul
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (2,219 reviews)
"Great hotel"

Reviewed on 13 Jul 2026

Hollywood Casino & Hotel St. Louis
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
The price is 2.625.237 ₫ per night from 3 Aug to 4 Aug
2.625.237 ₫
3.090.738 ₫ total
3 Aug - 4 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
9.2/10 Wonderful! (3,111 reviews)
"The staff was very friendly. The place was very clean. The fridge was tiny and could be bigger as it was only a half-sized mini fridge, but I was able to squeeze everything in there. Side note: if you have Alpha Gal syndrome and are fume reactive, breakfast/evening snacks are served in the lobby ..."

Reviewed on 14 Jul 2026

Pear Tree Inn St. Louis Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.



Midtown Travel Guide

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