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Our top choices for Midtown hotels

Courtyard
Element St. Louis Midtown

Element St. Louis Midtown

Element St. Louis Midtown
3.0 star property
Midtown
9.0 out of 10, Wonderful, (645)
"Everything was excellent. The staff were very friendly and helpful. The accommodations were excellent and it was a great location near every where we were going."
United States
Angela
The price is 3.448.444 ₫
4.032.231 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Element St. Louis Midtown
BBQ/picnic Area
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown
3.0 star property
Midtown
7.8 out of 10, Good, (1002)
"Ok"
United States
Shamari
The price is 2.895.640 ₫
3.443.756 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Residence Inn by Marriott St Louis Downtown
Lobby
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 3.4 km from Midtown
8.4 out of 10, Very good, (4013)
"Everything was great!"
United States
Kathryn
The price is 2.238.135 ₫
2.639.410 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hyatt Regency St. Louis at The Arch
Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis, 3 km from Midtown
8.8 out of 10, Excellent, (1158)
"Really enjoyed my stay! Highly recommend this place. It’s a vintage style hotel that is very well kept uo"
United States
Varun
The price is 2.108.552 ₫
2.507.679 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Exterior
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
29.2 km from Midtown
9.6 out of 10, Exceptional, (1037)
"Absolutely amazing stay very nice play our family stays there every time very kid friendly"
United States
Matthew
The price is 3.421.857 ₫
3.968.870 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Drury Plaza Hotel St. Louis Chesterfield
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
17.3 km from Midtown
9.4 out of 10, Exceptional, (2748)
"Great place to stay before your early morning flight. "
United States
Henry
The price is 2.368.897 ₫
2.788.765 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Pear Tree Inn St. Louis Airport
Restaurant
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL
3.0 star property
26.6 km from Midtown
9.6 out of 10, Exceptional, (1000)
"Excellent location, clean and spacious room, great morning breakfast with numerous choices and of course helpful and pleasant staff."
United States
David
The price is 2.684.785 ₫
3.113.866 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites St. Louis O'Fallon, IL
Exterior
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
9.8 km from Midtown
8.8 out of 10, Excellent, (3032)
"Clean room, good breakfast and good location "
United States
Martin
The price is 2.389.429 ₫
2.789.554 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Clayton Plaza Hotel & Extended Stay
Courtyard
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
24.5 km from Midtown
7.4 out of 10, Good, (1000)
"Clean lobby, super friendly staff, effortless check in. There’s even a small market with food and essentials right next to the check in desk. "
United States
Jen
The price is 1.876.375 ₫
2.176.369 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Exterior
Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG
2.5 star property
29.4 km from Midtown
9.4 out of 10, Exceptional, (705)
"Great breakfast ! "
United States
Jeanette
The price is 2.448.132 ₫
2.716.938 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Troy by IHG
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
23.2 km from Midtown
8.0 out of 10, Very good, (1042)
"Everything was clean and friendly staff overall good experience "
United States
dennis
The price is 2.237.540 ₫
2.584.490 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Free daily continental breakfast
Super 8 by Wyndham Troy IL/St. Louis Area

Super 8 by Wyndham Troy IL/St. Louis Area

Super 8 by Wyndham Troy IL/St. Louis Area
2.0 star property
29.2 km from Midtown
8.0 out of 10, Very good, (1001)
"clean room, gracious and efficient staff "
United States
Catherine
The price is 1.678.155 ₫
1.862.417 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Super 8 by Wyndham Troy IL/St. Louis Area
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis, 3.1 km from Midtown
8.8 out of 10, Excellent, (1242)
"Great hospitality"
United States
Alejandro
The price is 2.892.481 ₫
3.439.998 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Embassy Suites by Hilton St. Louis Downtown
Daily cooked-to-order breakfast for a fee
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
11.9 km from Midtown
9.0 out of 10, Wonderful, (1449)
"Awesome place to stay!!"
United States
Kaitlyn
The price is 2.605.813 ₫
3.416.065 ₫ total
includes taxes & fees
23 Dec - 24 Dec
River City Casino & Hotel
Rooftop terrace
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 3.4 km from Midtown
9.4 out of 10, Exceptional, (3283)
"Our stay was very enjoyable. Location was great and kids loved the indoor pool!"
United States
Christy
The price is 3.553.477 ₫
4.155.045 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Drury Plaza Hotel St. Louis at the Arch
Terrace/patio
Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia
2.5 star property
21.2 km from Midtown
8.6 out of 10, Excellent, (476)
"Breakfast was great and a very good atten"
United States
John
The price is 2.525.525 ₫
2.802.827 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
Hampton Inn St. Louis - Columbia
Lobby
Pear Tree Inn St. Louis Convention Center

Pear Tree Inn St. Louis Convention Center

Pear Tree Inn St. Louis Convention Center
3.0 star property
Downtown St. Louis, 3.3 km from Midtown
9.0 out of 10, Wonderful, (1053)
"It was perfect for our stay in St. Louis to visit the arch."
United States
Jacob
The price is 2.474.193 ₫
2.893.008 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Pear Tree Inn St. Louis Convention Center
Exterior
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
21.3 km from Midtown
9.8 out of 10, Exceptional, (192)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is 2.969.610 ₫
3.295.764 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Principal Hotel
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
27.4 km from Midtown
9.4 out of 10, Exceptional, (1001)
"Good stay."
United States
Steven
The price is 2.917.752 ₫
3.353.285 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Free daily buffet breakfast
Holiday Inn Express & Suites Edwardsville by IHG

Holiday Inn Express & Suites Edwardsville by IHG

Holiday Inn Express & Suites Edwardsville by IHG
2.5 star property
27.8 km from Midtown
9.2 out of 10, Wonderful, (819)
"Always a good stay here!"
United States
Chelsie
The price is 3.053.584 ₫
3.511.011 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Edwardsville by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End

Central West End

If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Top Midtown Hotel Reviews

Frequently asked questions

What is Midtown like?
Travellers are sure to enjoy a stay in St. Louis's Midtown neighbourhood. Make sure that you visit Chaifetz Arena and Washington Avenue Historic District as part of your Midtown travel plans.
How many hotels will I be able to find in the Midtown area?
If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 30 Midtown hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Midtown, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to get top deals in Midtown.
What are the top things to see and do in Midtown?
Explore Midtown's landmarks such as Washington Avenue Historic District, Samuel Cupples House and Scott Joplin House State Historic Site and learn about the local history. Chaifetz Arena and Topgolf are also a couple of places to visit in the neighbourhood. St. Louis Union Station and Gateway Arch are some popular places to visit in the area around Midtown. While you're out sightseeing, .ZACK Theater and The MOTO Museum are a couple of additional sights to visit in St. Louis.
How can I get around Midtown and the greater St. Louis area?
Ready to get out and explore the city? Grand Station is the closest metro station.