Compare and book 4 Star hotels in Panama City, Panamá Province

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama City 4 Star Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Panama City 4 Star Hotels

Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4.0 star property
Tocumen
8.4 out of 10, Very good, (2325)
"The room was clean and the staff were nice! "
United States
CECILIA
The price is 2.900.810 ₫
3.190.891 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Crowne Plaza Panama Airport by IHG
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very good, (1247)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
The price is 3.224.430 ₫
3.546.873 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Megapolis Hotel Panamá
View from property
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1032)
"Wonderful stay!"
United States
Martha
The price is 4.612.552 ₫
5.073.781 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Las Americas Golden Tower Panama
Terrace/patio
Marriott Panama Hotel

Marriott Panama Hotel

4.0 star property
Panama City
9.0 out of 10, Wonderful, (1000)
"Great breakfast "
United States
Amina
The price is 3.738.373 ₫
4.112.342 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Marriott Panama Hotel
Front of property
Novotel Panama City

Novotel Panama City

4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1009)
"Room very clean, nice staffs and good location "
United States
Hayden
The price is 2.539.527 ₫
2.793.480 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Novotel Panama City
Restaurant
Studio Coliving

Studio Coliving

4.5 star property
Bella Vista
7.8 out of 10, Good, (574)
"The staff was friendly and always helpful when I had requests. The room was"
United States
Toni-Q
The price is 1.165.898 ₫
1.282.488 ₫ total
includes taxes & fees
6 Dec - 7 Dec
Studio Coliving
Exterior
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4.0 star property
San Francisco
8.6 out of 10, Excellent, (1425)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is 2.091.731 ₫
2.300.904 ₫ total
includes taxes & fees
8 Dec - 9 Dec
Decapolis Hotel Panama City
Outdoor pool, pool umbrellas, pool loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1113)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
The price is 2.639.737 ₫
2.903.711 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Front of property – evening/night
American Trade Hotel

American Trade Hotel

4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (600)
"Excellent service and great rooms on a beautiful and historical building"
Canada
Manuel
The price is 7.690.367 ₫
8.459.404 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
American Trade Hotel
Terrace/patio
Sheraton Grand Panama

Sheraton Grand Panama

4.0 star property
San Francisco
8.6 out of 10, Excellent, (988)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is 3.560.085 ₫
3.916.094 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Sheraton Grand Panama
Outdoor pool
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4.0 star property
Bella Vista
9.0 out of 10, Wonderful, (610)
"Friwndly staff, clean rooms and a very convenient location."
United States
Alisa
The price is 1.933.932 ₫
2.871.889 ₫ total
includes taxes & fees
8 Dec - 9 Dec
Waymore Hotel Spa & Casino
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1002)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is 2.667.629 ₫
2.934.392 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott Panama Metromall
Exterior
Holiday Inn Panama Distrito Financiero by IHG

Holiday Inn Panama Distrito Financiero by IHG

4.0 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"The staff members are amazing!!"
United States
Cherisse
The price is 1.898.856 ₫
2.088.742 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Holiday Inn Panama Distrito Financiero by IHG
47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1002)
"Great staff, perfect location, and delicious breakfast. "
United States
Tatiana
The price is 6.169.201 ₫
6.786.121 ₫ total
includes taxes & fees
8 Dec - 9 Dec
Central Hotel Panama Casco Viejo
Exterior
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4.0 star property
San Francisco
8.8 out of 10, Excellent, (1001)
"Perfect stay "
United States
pedro
The price is 3.115.970 ₫
3.427.567 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Courtyard by Marriott Panama Multiplaza Mall
Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, pool loungers
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4.0 star property
San Francisco
9.0 out of 10, Wonderful, (534)
"Amazing hotel amazing view service great location perfect "
United States
Melissa
The price is 3.788.194 ₫
4.167.014 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Residence Inn by Marriott Panama City
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (116)
"Great hotel fair price"
United States
Santiago
The price is 3.560.085 ₫
3.916.094 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Hyatt Regency Panama City
Front of property
Hotel San Felipe

Hotel San Felipe

4.0 star property
Casco Viejo
9.4 out of 10, Exceptional, (242)
"Really nice staff and property is in amazing location "
United States
Michael
The price is 2.769.164 ₫
3.046.081 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hotel San Felipe
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (257)
"Great location!"
United States
Erik
The price is 8.181.603 ₫
8.999.763 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Hotel La Compañía Casco Antiguo
2 outdoor pools, pool umbrellas, pool loungers
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 star property
Amador
8.4 out of 10, Very good, (1014)
"Love the location and convenience "
United States
Patricia
The price is 1.838.198 ₫
2.022.018 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Radisson Hotel Panama Canal
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Panama City.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
The price is 3.017.836 ₫ per night from 8 Dec to 9 Dec
3.017.836 ₫
3.319.620 ₫ total
8 Dec - 9 Dec
includes taxes & fees
9/10 Wonderful! (4,637 reviews)
Still don't see what you're looking for?
See all properties in Panama City.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
Panoramic view at the Downtown of Panama City - Panama

Top Panama City Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Panama City?
Continental Hotel Panamá is a 4-star hotel in Panama City that's popular among Expedia customers. An art gallery and proposal/romance packages are just a couple of its amenities. Travellers also recommend Hotel El Panama by Faranda Grand, a member of Radisson Individuals. From a swimming pool to a steam room, it offers conveniences that cater to every aspect of your relaxation and entertainment.
How much does it cost to stay in a 4-star hotel in Panama City?
To lock in a 4-star hotel in Panama City that fits your budget, make use of Expedia's handy search filters. Take a look at the availability during your holiday dates and use our pricing filter to set your limit. You can also sort your results by the most affordable escape first.

  • Search for the lowest price from 3.319.620 ₫

What's the difference between 5-star and 4-star hotels in Panama City?
Offering a friendly traveller experience and upmarket décor, 4-star hotels are a fantastic option for your Panama City holiday. These types of accommodation generally feature loads of useful amenities that make it a breeze to unpack and unwind — think 24-hour room service, gyms and pools. Or enjoy even more lavishness at a 5-star hotel designed to indulge you in high-end perks and amenities. Concierge assistance, complimentary toiletries and fine dining are typically included at these swanky properties.

Explore a world of travel with Expedia