Compare and book 4 Star hotels in St. Charles, St. Louis
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on St. Charles 4 Star Hotels
Top St. Charles 4 Star Hotels

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
8.4 out of 10, Very good, (3824)
The price is 3.366.255 ₫
3.969.791 ₫ total
includes taxes & fees
1 Jul - 2 Jul

DoubleTree by Hilton St. Louis Airport
DoubleTree by Hilton St. Louis Airport
7.8 out of 10, Good, (760)
The price is 2.972.221 ₫
3.487.546 ₫ total
includes taxes & fees
6 Jul - 7 Jul

Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
8.8 out of 10, Excellent, (623)
The price is 4.413.969 ₫
5.185.883 ₫ total
includes taxes & fees
3 Jul - 4 Jul

Moonrise Hotel
Moonrise Hotel
9.0 out of 10, Wonderful, (1775)

Renaissance St. Louis Airport Hotel
Renaissance St. Louis Airport Hotel
8.4 out of 10, Very good, (1011)
The price is 3.105.305 ₫
3.632.833 ₫ total
includes taxes & fees
31 Jul - 1 Aug

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very good, (1008)
The price is 4.413.969 ₫
5.591.637 ₫ total
includes taxes & fees
1 Jul - 2 Jul

21C Museum Hotel St Louis
21C Museum Hotel St Louis
9.0 out of 10, Wonderful, (1205)
The price is 4.203.905 ₫
5.046.058 ₫ total
includes taxes & fees
31 Jul - 1 Aug

Hilton St. Louis at the Ballpark
Hilton St. Louis at the Ballpark
7.4 out of 10, Good, (1022)
The price is 4.931.955 ₫
5.865.895 ₫ total
includes taxes & fees
1 Jul - 2 Jul
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in St. Charles.

Four Seasons Hotel St Louis
999 North Second Street, St. Louis, MO
The price is 12.525.600 ₫ per night from 2 Jul to 3 Jul
12.525.600 ₫
14.646.059 ₫ total
2 Jul - 3 Jul
includes taxes & fees
9.4/10 Exceptional! (1,000 reviews)
Still don't see what you're looking for?
See all properties in St. Charles.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about St. Charles
Stroll down Historic Main Street, where 1812-era charm meets modern boutiques and eateries. Bike the scenic Katy Trail or try your luck at Ameristar Casino before exploring the Lewis & Clark Boathouse.

Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in St. Charles by Star Rating
Areas of St. Charles
Accommodation near St. Charles attractions
- Hotels near Ameristar Casino St. Charles
- Hotels near Lindenwood University
- Hotels near Fast Lane Classic Cars
- Hotels near Katy Trail
- Hotels near Lewis & Clark Boathouse and Nature Center
- Hotels near Missouri Bluffs Golf Course
- Hotels near Weldon Spring Site Interpretive Center
- Hotels near Jaycee Park
- Hotels near Missouri Artists on Main
- Hotels near Frenchtown Heritage Museum
- Hotels near Mississippi River
- Hotels near Missouri River
Choose Your St. Charles Hotel Style
- Casino Hotels in St. Charles
- Family-Friendly Hotels in St. Charles
- Golf Hotels in St. Charles
- Historic Hotels in St. Charles
- Hotels Suites in St. Charles
- Hotels with Balcony in St. Charles
- Hotels with Breakfast in St. Charles
- Hotels with Connecting Rooms in St. Charles
- Hotels with Gym in St. Charles
- Hotels with Hot Tubs in St. Charles
- Hotels with Indoor Pools in St. Charles
- Hotels with Parking in St. Charles
- Hotels with Pool in St. Charles
- Hotels with Restaurant in St. Charles
- Hotels with Wifi in St. Charles
- Hotels with a Bar in St. Charles
- Romantic Hotels in St. Charles
- Shopping Hotels in St. Charles
- Winery Hotels in St. Charles