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Check availability on Downtown St. Louis 5 Star Hotels

Our top choices for Downtown St. Louis 5-star hotels

Rooftop bar
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
The price is 10.940.230 ₫
12.792.301 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Four Seasons Hotel St Louis
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Downtown St. Louis.
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO
The price is 2.451.666 ₫ per night from 25 Dec to 26 Dec
2.451.666 ₫
2.915.742 ₫ total
25 Dec - 26 Dec
includes taxes & fees
8.6/10 Excellent! (1,138 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Downtown St. Louis Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Downtown St. Louis?
Unwind in luxurious surroundings at Four Seasons Hotel St Louis. Highly rated by Expedia guests for its elevated standard of opulence and comfort, this 5-star hotel located around the St. Louis neighbourhood of Downtown St. Louis surpasses expectations.
How much does it cost to stay in a 5-star hotel in Downtown St. Louis?
There are various pricing options for 5-star hotels in Downtown St. Louis on Expedia. How much you'll pay will depend on when you plan to travel, length of stay and other factors. Compare all of the available properties for your chosen dates and use our pricing and other filters to lock in the ideal luxury stay.

  • Search for the lowest price per night from 2.769.980 ₫

What makes a hotel 5 stars in Downtown St. Louis?
Faultless guest service is at the heart of every 5-star hotel in Downtown St. Louis. From the moment you enter the lobby, staff cater to your every need, whether offering luggage assistance and storage or providing a nightly turn-down service. In addition, hotels must offer superior conveniences to qualify for a 5-star rating. These can include luxury toiletries, an on-site spa, pools, gastronomic restaurants and knowledgeable concierge.

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