Compare and book 5 Star hotels in St. Louis, Missouri

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on St. Louis 5 Star Hotels

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Top St. Louis 5 Star Hotels

Rooftop bar
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
The price is 10.940.230 ₫
12.792.301 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Four Seasons Hotel St Louis
Meeting facility
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is 13.154.638 ₫
15.356.461 ₫ total
includes taxes & fees
23 Dec - 24 Dec
The Ritz-Carlton, St. Louis
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Louis.
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO
The price is 2.662.663 ₫ per night from 12 Dec to 13 Dec
2.662.663 ₫
3.166.679 ₫ total
12 Dec - 13 Dec
includes taxes & fees
8.6/10 Excellent! (1,138 reviews)
Still don't see what you're looking for?
See all properties in St. Louis.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

St. Louis and related destinations

The Gateway Arch towers 630 feet above the Mississippi, with a tram that takes you to spectacular views at the top. Explore Forest Park's free museums, catch a Cardinals game at Busch Stadium, and don't miss Ted Drewes' frozen custard that locals swear by.

See all hotels in St. Louis

Top St. Louis Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in St. Louis?
Treat yourself to a luxurious stay at Four Seasons Hotel St Louis. This is among the top 5-star hotels in St. Louis based on Expedia customer reviews. From its guest services to its well-appointed rooms and prime location, you can rely on the highest standard of excellence.
How much does it cost to stay in a 5-star hotel in St. Louis?
You'll find many different pricing options for a 5-star hotel in St. Louis on Expedia. The amount you pay will depend on your travel dates, trip length and other factors. Compare available accommodation for your desired dates and use our pricing and other filters to lock in the ideal high-end stay.

  • Search for the lowest price per night from 2.937.858 ₫

What makes a hotel 5 stars in St. Louis?
From gourmet dining venues and 24/7 fitness centres to pools and the finest bedding, the 5-star experience in St. Louis is all about indulgence and comfort. But it takes more than just upscale perks to earn a 5-star rating. Accommodation must also deliver remarkable guest-focused services like in-room massage treatments, on-site dry cleaning and laundry and a nightly turn-down service.

Explore a world of travel with Expedia